Ask about this productRelated genes to: ZNF683 Blocking Peptide
- Gene:
- ZNF683 NIH gene
- Name:
- zinc finger protein 683
- Previous symbol:
- -
- Synonyms:
- MGC33414, Hobit
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-31
- Date modifiied:
- 2015-08-26
Related products to: ZNF683 Blocking Peptide
Related articles to: ZNF683 Blocking Peptide
- Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a major global cause of mortality. Persistent immunosuppression contributes to secondary infections and adverse outcomes, yet the mechanisms underlying late-phase T-cell dysfunction remain incompletely understood. - Source: PubMed
Publication date: 2026/03/06
Hou MingtongMi ZhaoOuyang ShiyuWang WenboZhao GuiquanWang Shengbao - Stromal remodeling constitutes a hallmark of gastric cancer (GC) progression, yet the intercellular signaling networks orchestrating this process remain incompletely understood. - Source: PubMed
Publication date: 2026/02/27
Cheng KangXu JingquanYang JianleiZhang Zili - The tree shrew is a potential mammalian model for preclinical studies, but its immune system is not well understood. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to construct a comprehensive cell atlas of the postnatal thymus development of the tree shrew. Our data revealed that the tree shrew thymocytes exhibit conserved features with species-specific variations in cell states and types when compared to those of humans and pigs. We found that tree shrew thymocyte markers are generally intermediate between humans and pigs, with some resembling each species. Some are different from both humans and pigs, such as the expression of the ZNF683 gene, which is not detected until the later stage of CD8aa cells development. The tree shrew thymic cells were classified into 20 types based on gene expression, confirming previous findings of basic thymic immune cells in tree shrews. The results show that immature immune cells were present in a higher proportion in young tree shrews compared to old ones. As tree shrews mature, there was a significant increase in the proportion of late-differentiated functional cells, such as Treg cells. A pseudo-temporal analysis revealed that thymocytes in tree shrews predominantly originated from a common starting point, with the exception of B and dendritic cells. A pseudotime trajectory analysis identified 17 gene modules, aligning with known T cell development stages and markers. Aging-related transcriptional changes in tree shrew thymus cells initially rise and then fall with age. Older tree shrews show increased expression of aging-related genes and decreased or absent anti-aging genes. These findings elucidate key differentiation events in the maturation of thymopoiesis in tree shrews and offer valuable insights into the development of T cells in this species. - Source: PubMed
Publication date: 2026/01/16
Tang HaiboHe YunlinZhang LifengCao YingyingLi BaoyingLiang LiangYun ChengxiaTao JunyuZhai ShanshanLi ZhuxinDai YinghanHu YanlingLeng Jing - Hypopharyngeal squamous cell carcinoma (HPSCC), an aggressive head and neck cancer with dismal prognosis, faces persistent chemoresistance to standard TPF (docetaxel, cisplatin, 5-fluorouracil) regimen. However, the immunological mechanisms underlying chemoresistance remain undefined. Here, we perform longitudinal single-cell RNA sequencing (scRNA-seq) profiling of paired pre-/post-TPF HPSCC specimens, mapping immune cell dynamics underlying chemoresistance. Our study identifies ZNF683 natural killer (NK) cells as a gatekeeper of chemotherapy efficacy through integrated single-cell transcriptomics, spatial multiplex immunohistochemistry and functional validation. Moreover, pretreatment baseline enrichment of ZNF683 NK cells predicts TPF response, while GZMKCD8 effector memory T cells function as the predominant immunologic effector to successful TPF intervention. Mechanistically, bioinformatics and in vitro coculture data reveal that ZNF683 NK cells directly interact with CD8 T cells, and drive an MHC-I-dependent licensing of polyfunctional GZMKCD8 effector memory T cells. Collectively, this NK-CD8 axis provides a potential predictive biomarker and therapeutic target to overcome chemoresistance in patients with HPSCC. - Source: PubMed
Publication date: 2026/01/21
Li GuoXiao WenhaoWu HaijunLiu ChaoGong LiangZhang HaoyuShao ZhuoBai JingXia XuefengYi XinWang YunyunLu ShanhongShe LiWang JunchengZhu GangcaiZhou XiaojuanWang WenmeiShen LiangfangZhang NuWang XingweiHuang DonghaiHou JunweiQiu YuanzhengZhang XinHung Mien-ChieLiu Yong - Oropharyngeal squamous cell carcinoma (OPSCC) is a major subtype of head and neck cancer, with prognosis increasingly influenced by the tumour immune microenvironment. Although immune checkpoint inhibitors have improved outcomes for some patients, reliable predictive biomarkers remain limited. - Source: PubMed
Publication date: 2025/11/15
Minarik LukaKhoueiry RitaLeskur MirelaCahais VincentHerceg ZdenkoGlavina Durdov MericaBenzon Benjamin