Ask about this productRelated genes to: ENO2 Blocking Peptide
- Gene:
- ENO2 NIH gene
- Name:
- enolase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-04-28
Related products to: ENO2 Blocking Peptide
Related articles to: ENO2 Blocking Peptide
- Prostate cancer (PCa) and Alzheimer's disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options. Identifying shared molecular drivers may reveal new treatment targets. - Source: PubMed
Publication date: 2026/08/20
Wang MengxueQian YanrongHuang EnyaoChu ChunyanGao TianChen ShengrongZhao NaLuo CaichenLiu YifanZheng XiejunhaoHu HaowenHan BowenChen MingMao WeipuLi Wenchao - Acetaminophen (APAP) also known as paracetamol, is the only antipyretic and analgesic agent that can be administered to pregnant women. In addition to hepatotoxicity in cases of an overdose, the developmental neurotoxicity of APAP has been reported in model organisms. In this study, developing zebrafish were used to assess the neurotoxic effects of waterborne APAP exposure (0.039-2.5 mM). At 120 hpf, the spontaneous swimming distance was significantly reduced at all tested APAP concentrations under alternating light-dark conditions. Touch-evoked escape velocity, which assesses the motor function, was not significantly affected at any concentration and it increased at moderate APAP doses. The optokinetic response was only reduced at 2.5 mM APAP concentrations, suggesting that the decrease in spontaneous swimming at low APAP doses is unlikely to be due to motor or visual impairments. Vibration-evoked responses, indicative of the sensory function, were slightly but significantly diminished at 0.625 and 2.5 mM APAP concentrations. At 72 h post-fertilization (hpf), acridine orange and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining showed that exposure to 2.5 mM APAP resulted in regulated cell death in the cerebellum, retina, and dorsal trunk. Some APAP-induced cell death in the dorsal trunk was confirmed to be of neuronal origin using Tg(eno2:Cerulean) transgenic zebrafish. N-acetylcysteine, a well-known antioxidant and antidote for APAP toxicosis in humans, partially attenuated APAP-induced cell death. These results suggest that APAP induces developmental neurobehavioral and sensory organ toxicity in the absence of detectable regulated cell death under the present experimental conditions. - Source: PubMed
Publication date: 2026/08/28
Wang HuanChen ChaobaoOnoo ShutaYuge MizukiDong WenjingIshiguro YuuyaNakamura TatsuroKubota AkiraNishimura YuheiTeraoka Hiroki - Nowadays, most cancer research still depends on traditional cell culture in Petri dishes or cell culture flasks which do not have the ability to mimic physiological-like conditions in vitro. However, the behavior of cancer cells strongly relies on the interaction with their extracellular microenvironment. Consequently, current advanced approaches focus on three-dimensional (3D) cell culture to overcome such limitations and to enable a better understanding of fundamental processes including cancer development, progression, apoptosis and invasion. However, transcriptional adaptation to and temporal stability within an in vitro 3D microenvironment still appear to be remarkably understudied. In our study, we compared the cellular behavior and whole transcriptome gene expression of three frequently used non-invasive cancer cell lines (HCT-116, A549 and T47D), embedded within a collagen I (Coll I)-based 3D microenvironment to its counterparts grown as simple monolayers in a time-dependent manner. Thereby, changes in morphology and doubling time became apparent between both cultivation systems, and RNA sequencing-based transcriptome-wide analysis revealed a remarkable increase in transcriptional complexity under 3D conditions. In line with the 3D-dependent phenotype, unidirectional shifts for genes involved in cell cycle regulation (e.g., , ), cell-matrix interaction (e.g., , ) and metabolic signaling (e.g., , ) were identified over time, being either activated or repressed. Interestingly, all three cell lines cultured in Coll I matrices displayed a highly distinct RNA content and composition, along with a significantly increased number of expressed protein-coding genes (increase of 3-6%) as well as long non-coding RNAs (increase of 26-48%), suggesting a more multifaceted transcription profile under 3D conditions. Our work clearly highlights that an in vitro 3D Coll I-based cell culture system has an incisive cell-specific impact on the whole transcriptome on a qualitative and quantitative level. This tremendous transcriptional reprogramming implies essential changes in gene regulatory networks and affects phenotypic cancer cell behavior, which should be considered when focusing on downstream applications. - Source: PubMed
Publication date: 2026/08/01
Wießner-Kroh TheresaHübschmann StefanieMarquardt GudrunSzczesny JenniferFaxel MiriamRubner StefanPapasotiriou Ioannis - The electrocatalytic nitrite reduction reaction (eNO2-RR) presents an extraordinary surge in clean yet green ammonia (NH3) synthesis due to mild operation and its promising compatibility with renewable energy sources. Nevertheless, the sluggish NO2- reaction kinetics and the competing hydrogen evolution reaction (HER) remain challenging for efficient NO2--to-NH3 electrosynthesis. Herein, we reveal a strong dependence of H2O structure on KCl concentration in the electrolyte and decouple the KCl-induced water disordering mechanism for efficient NH3 electrosynthesis. This disrupts the hydrogen-bond network of H2O and increases the proportion of K+-H2O species, thereby transforming an ordered proton-hopping network into a disordered environment. This ordering-to-disordering transition increases the activation entropy and lowers the activation enthalpy, leading to a reduction in the apparent free energy and enabling a 2.9-fold enhancement in NH3 production compared to the conventional electrolyte. The KCl-water electrolyte exhibits an exceptional NH3 yield rate of 111.3 mg cm-2 h-1, a Faradaic efficiency of 99.6% at -0.5 V vs RHE, and stable operation for over 1000 h at 1 A cm-2. Multiscale theoretical simulations further confirm that the K+ ions suppress the HER by elevating the water dissociation barrier from 0.1 to 0.7 eV, while the Cl- ions lower the *NO-to-*NOH hydrogenation barrier, thereby promoting the eNO2-RR kinetics. Moreover, the proposed KCl-induced H2O disordering mechanism for efficient eNO2-RR is universal, delivering consistent performance gains across various catalysts. - Source: PubMed
Qian BingzhiYu ChangLiu YingbinMa RulongCai ZhenHe FengQiu Jieshan - Neuroendocrine prostate cancer (NEPC) is an aggressive treatment-associated lineage state emerging with potent androgen receptor (AR) pathway inhibition. Although treatment-emergent NEPC is increasingly recognized, the transcriptional consequences of sustained AR suppression remain incompletely defined. It remains unclear to what extent AR-targeted therapies reshape cellular identity and engage neuroendocrine-associated transcriptional programs without full lineage-defining differentiation. - Source: PubMed
Publication date: 2026/07/24
Watanabe RyutaChosei MamiArai HarunaMiura NoriyoshiKikugawa TadahikoSaika Takashi