Ask about this productRelated genes to: ZXDA Blocking Peptide
- Gene:
- ZXDA NIH gene
- Name:
- zinc finger X-linked duplicated A
- Previous symbol:
- -
- Synonyms:
- ZNF896
- Chromosome:
- Xp11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-02
- Date modifiied:
- 2018-04-26
Related products to: ZXDA Blocking Peptide
Related articles to: ZXDA Blocking Peptide
- [This corrects the article DOI: 10.3389/fcell.2022.929288.]. - Source: PubMed
Publication date: 2022/09/14
- Alterations in the gene encoding the E3 ubiquitin ligase substrate receptor FBXO38 have been associated with several diseases, including early-onset motor neuronopathy. However, the cellular processes affected by the enzymatic action of FBXO38 are not yet known. Here, we identify the zinc finger proteins ZXDA/B as its interaction partners. FBXO38 controls the stability of ZXDA/B proteins via ubiquitination and proteasome-dependent degradation. We show that ZXDA/B proteins associate with the centromeric protein CENP-B and that the interaction between ZXDA/B and FBXO38 or CENP-B is mutually exclusive. Functionally, ZXDA/B factors control the protein level of chromatin-associated CENP-B. Furthermore, their inappropriate stabilization leads to upregulation of CENP-A and CENP-B positive centromeric chromatin. Thus we demonstrate a previously unknown role of cullin-dependent protein degradation in the control of centromeric chromatin integrity. - Source: PubMed
Publication date: 2022/06/23
Dibus NikolKorinek VladimirCermak Lukas - To determine the presence of sexual dimorphic transcription and how in vitro culture environments influence X-linked gene transcription patterns in preimplantation embryos, we analyzed mRNA expression levels in in vivo-derived, in vitro-fertilized (IVF), and cloned porcine blastocysts. Our results clearly show that sex-biased expression occurred between female and male in vivo blastocysts in X-linked genes. The expression levels of XIST, G6PD, HPRT1, PGK1, and BEX1 were significantly higher in female than in male blastocysts, but ZXDA displayed higher levels in male than in female blastocysts. Although we found aberrant expression patterns for several genes in IVF and cloned blastocysts, similar sex-biased expression patterns (on average) were observed between the sexes. The transcript levels of BEX1 and XIST were upregulated and PGK1 was downregulated in both IVF and cloned blastocysts compared with in vivo counterparts. Moreover, a remarkable degree of expression heterogeneity was observed among individual cloned embryos (the level of heterogeneity was similar in both sexes) but only a small proportion of female IVF embryos exhibited variability, indicating that this phenomenon may be primarily caused by faulty reprogramming by the somatic cell nuclear transfer (SCNT) process rather than in vitro conditions. Aberrant expression patterns in cloned embryos of both sexes were not ameliorated by treatment with Scriptaid as a potent HDACi, although the blastocyst rate increased remarkably after this treatment. Taken together, these results indicate that female and male porcine blastocysts produced in vivo and in vitro transcriptional sexual dimorphisms in the selected X-linked genes and compensation of X-linked gene dosage may not occur at the blastocyst stage. Moreover, altered X-linked gene expression frequently occurred in porcine IVF and cloned embryos, indicating that X-linked gene regulation is susceptible to in vitro culture and the SCNT process, which may eventually lead to problems with embryonic or placental defects. - Source: PubMed
Publication date: 2012/12/07
Park Chi-HunJeong Young HeeJeong Yeun-IkLee Se-YeongJeong Yeon-WooShin TaeyoungKim Nam-HyungJeung Eui-BaeHyun Sang-HwanLee Chang-KyuLee EunsongHwang Woo Suk - The transcription factor ZXDC, a member of ZXD protein family, forms transcriptionally active complex with ZXDA and participates in the regulation of MHCII gene expression. In this work we investigate the expression of a large group of genes in kidney embry cell of line HEK293 with overexpression of transcription factor ZXDC for identification of genes, which transcription is controlled by this transcription factor. We have shown that overexpression of the transcription factor ZXDC in kidney embryo cell of HEK293 line significantly changes the level of expression of large group of genes, which control the behavior of different cell processes, in particular cell cycle, cell proliferation and differentiation. The expression of most of these genes is significantly increased in the kidney cell line HEK293 with overexpression of transcription factor ZXDC, in particular EGR2, BDNF, CDKN1C and IL5Ra genes. Our results clearly demonstrated that transcription factor ZXDC plays a significant role in the regulation of expression of a large group of genes, which control important cell processes. - Source: PubMed
Halkin O VMinchenko O H - The zinc finger X-linked duplicated A (ZXDA) and ZXDC proteins are both required for robust transcription of major histocompatibility complex class II (MHC II) genes. Aside from the full length ZXDC mRNA transcript, at least one additional mRNA is produced by the ZXDC gene, in which transcription initiates within the first exon and terminates within the seventh intron. The protein product produced from this transcript, which we have named ZXDC2, is truncated on both the N- and C-terminus. We demonstrate here that ZXDC2 functions to repress MHC II transcription induced in HeLa cells treated with IFN-gamma. We further demonstrate that ZXDC2 interacts with both ZXDA and ZXDC, suggesting a mechanism by which ZXDC2 may inhibit MHC II transcription. These studies not only provide additional support for the role of ZXD proteins in regulating MHC II transcription, but also demonstrate a unique mechanism for the synthesis of a mRNA isoform. - Source: PubMed
Publication date: 2009/09/24
Aleksandrova AnastasiiaGalkin OleksandrKoneni RupaFontes Joseph D