Ask about this productRelated genes to: HSPA4 Blocking Peptide
- Gene:
- HSPA4 NIH gene
- Name:
- heat shock protein family A (Hsp70) member 4
- Previous symbol:
- -
- Synonyms:
- HS24/P52, HSPH2
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-26
- Date modifiied:
- 2015-11-19
Related products to: HSPA4 Blocking Peptide
Related articles to: HSPA4 Blocking Peptide
- Heat stress (HS) is among the most economically consequential environmental challenges to global dairy production, causing progressive declines in milk yield, compositional quality, and mammary cellular integrity. The temperature-humidity index (THI) is the primary thermal load metric, with performance-impairment thresholds typically beginning at THI 68 in Holstein cattle, with severe impacts manifesting beyond THI 72; breed-specific thresholds for Jersey, Brown Swiss, and Simmental cows differ owing to their lower metabolic heat load and greater inherent thermotolerance. At the molecular level, HS activates heat shock protein networks-notably , , and -through / transcriptional activation, while simultaneously suppressing casein genes (, , ), lipogenic genes (, , ), amino acid transporters (, ), and mTOR-AKT-STAT5 translational machinery, collectively impairing milk biosynthetic capacity. Pro-apoptotic signaling (, upregulation; downregulation) and mitochondrial dysfunction further compromise mammary epithelial viability. Post-transcriptional regulation through miRNA, circRNA, and lncRNA competing endogenous RNA networks, alongside epitranscriptomic m6A modifications, adds further regulatory complexity. Genome-wide association studies have identified SNPs in , , , and as thermotolerance candidates compatible with sustained milk production. Nutritional supplementation with methionine, arginine, and taurine partially restores cellular synthetic capacity. Integrating multi-trait genomic selection with introgression, precision cooling, and targeted nutrition offers the most viable path toward climate-resilient, high-producing dairy cattle. - Source: PubMed
Publication date: 2026/05/21
Ma QingshanTharwat MohamedAlshanbari Fahad AKhan Muhammad Zahoor - DNA methylation plays a key role in mediating the anti-aging effects of glucose-lowering drugs. This study aims to systematically explore the potential anti-aging effects of target genes of FDA-approved glucose-lowering drugs and the underlying epigenetic mediators. - Source: PubMed
Publication date: 2026/05/21
Sun YuqiZheng HaonanHuang LanhuiMa MinGu RongrongWang ManqingFang SiSun YangboYang QianBi YufangZheng Jie - Chronic spontaneous urticaria (CSU) is an inflammatory skin disorder that substantially impairs patients' quality of life, yet its underlying pathogenesis remains incompletely understood. Oxidative stress (OS) has been proposed as a key contributing factor; however, the molecular mechanisms involved and their link to immune dysregulation are still unclear. This study aimed to systematically identify OS-related hub genes in CSU, investigate their association with immune infiltration, and evaluate their diagnostic potential. Expression profiles for urticaria were retrieved from the Gene Expression Omnibus (GEO) database. WGCNA identified OS-related module genes. Differential analysis, GSEA, PPI network, and ROC curve were used to screen OS-related hub genes, with their associations with immune infiltration and potential drug targets analyzed. Additionally, clinical blood samples from patients with CSU were collected to validate the expression levels of the hub genes via quantitative real-time PCR (qRT-PCR). Ten OS-related hub genes (e.g., HMGB1, PSMD1) were screened, with ROC AUC values > 0.76, indicating high diagnostic validity. Immune infiltration analysis revealed pronounced infiltration of 22 immune cell types in CSU patients, while hub gene HMGB1 showed significant negative correlations with activated dendritic cells and γδ T-cell abundance. 33 potential drugs targeting OS-related hub genes were predicted using DGIdb database. The qRT-PCR verification showed that the expression trends of the 9 candidate genes (HIST1H4H, HIST1H4D, SMARCC2, HMGB1, DDB2, TCF7L2, ITGA8, IRF4, and HSPA4) in the clinical samples were consistent with the results of the bioinformatics analysis, all exhibiting high diagnostic value (AUC > 0.76, p < 0.05). In this study, ten OS-related hub genes were identified, nine of which were validated for their diagnostic value in clinical samples. Several potential drug targets were also predicted. These findings provide new insights into the molecular classification, early diagnosis, and targeted therapy of CSU. Future studies involving larger clinical cohorts are warranted to validate these targets and further elucidate their roles in OS-driven CSU pathogenesis, thereby facilitating clinical translation. - Source: PubMed
Publication date: 2026/05/15
Li JuanGan HongwanZhong YuLiu Hongfu - The heat shock protein 70 (Hsp70) family is essential for maintaining protein homeostasis and mediating responses to environmental stresses; however, comprehensive characterizations of this family in the mandarin fish (Siniperca chuatsi) are presently absent. Through comparative genomic analysis, a total of 178 Hsp70 genes were identified across nine vertebrate species (human, mouse, and seven teleost fishes), including 17 unique members within the mandarin fish genome. Phylogenetic and gene structure analyses demonstrated that the mandarin fish Hsp70 family has remained highly conserved throughout teleost evolution, marked by lineage-specific expansions (notably in hspa1, hspa4, hspa8, and hspa12) and selective gene loss (e.g., the absence of hspa2 and hspa6). Specifically, tandem duplication was observed for hspa8.1 and hspa8.2, at the same time, two pairs of syntenic genes (hspa4a/hspa4b and hyou1/hspa8b) were found. Ka/Ks analysis further indicated that this gene family has mainly evolved under purifying selection. Transcriptomic profiling showed that hspa8.1 was constantly expressed across all examined tissues. In addition, under thermal stress and Aeromonas hydrophila infection, Hsp70 genes in mandarin fish exhibited divergent expression patterns: certain members contribute to basal homeostasis (e.g., hspa8.1), whereas others demonstrate specialized responses to heat/cold adaptation (e.g., hspa5) or pathogen infection (e.g., hspa1l). Respectively, these findings together provide a thorough understanding of the composition, evolutionary trajectory, and stress-responsive dynamics of the Hsp70 family, establishing a foundational molecular basis for understanding the environmental adaptation of mandarin fish. - Source: PubMed
Publication date: 2026/04/21
Liu YufeiYao XiaoliGao JinhuaIsmaeel HossamChen XiaowuZhao Jinliang - To characterise two endoplasmic reticulum (ER) stress markers, HSPA4 and SYVN1, in knee synovium from osteoarthritis (OA) patients and two non-osteoarthritic cohorts undergoing arthroscopic (scope) or trauma surgery. - Source: PubMed
Publication date: 2026/02/12
Roebuck Margaret MJamal JulianaWood AmandaSantini Alasdair J ALane BrianBou-Gharios GeorgeFrostick Simon PWong Pooi-Fong