Ask about this productRelated genes to: BAG3 Blocking Peptide
- Gene:
- BAG3 NIH gene
- Name:
- BCL2 associated athanogene 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q26.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2019-04-23
Related products to: BAG3 Blocking Peptide
Related articles to: BAG3 Blocking Peptide
- Ménière disease (MD) is a chronic inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Diagnosis is clinical, and no validated peripheral biomarkers are available. Although endolymphatic hydrops is a hallmark, its poor correlation with symptom severity suggests broader systemic mechanisms. - Source: PubMed
Publication date: 2026/06/22
Chiarella GiuseppeCuda GiovanniParrotta Elvira IScalise StefaniaCarvelli SimonaScarpa AlfonsoScaramuzzino LuanaCovello RaffaeleMartines FrancescoNeri GiampieroFetoni Anna RViola Pasquale - Dilated cardiomyopathy (DCM) is a leading cause of heart failure with notable sex differences in susceptibility and progression. Although sarcomere mutations such as cardiac actin ACTC1 p.T126I contribute to familial DCM, the in vivo effects and sex-specific consequences remain unclear. We generated a zebrafish model carrying the orthologous Acta1b p.T126I mutation and conducted longitudinal, sex-stratified analyses of cardiac function, morphology and gene expression. Mutants showed variable onset of cardiac dysfunction, with progressive DCM, pericardial effusion, ventricular dilation, and reduced survival in adults. Female mutants exhibited earlier and sustained diastolic dysfunction, greater cardiac remodeling and significantly lower survival compared to males, revealing pronounced sexual dimorphism. Molecular profiling at a pre-symptomatic stage identified upregulation of nppb, downregulation of hypertrophic transcription factors (gata4, mef2ca), and sex-specific alterations in calcium handling genes (serca2, pln1, slc8a1a) and proteostasis regulators (hsf1, bag3). Older stages demonstrated a variable shift of individuals' gene expression to cardiac remodeling and decompensation. These findings demonstrate that the Acta1b p.T126I mutation drives progressive, sex-specific DCM in zebrafish, highlighting biological sex as a critical modifier of sarcomeric cardiomyopathy progression and targeted therapy development. - Source: PubMed
Publication date: 2026/08/07
Prill KendalDawson John F - - Source: PubMed
Publication date: 2026/08/04
Manzo PaolaCammarota Anna LisaBasile AnnaDel Papa NicolettaIervolino MatteoUnfer VittorioTurco Maria CaterinaDe Marco Margot - Resistance exercise (RE) improves strength and muscle mass, with multiple benefits for human health. However, intense RE also induces acute myofibrillar damage. The molecular mechanisms that preserve, mark, degrade, and restore damaged proteins to keep skeletal muscle working under RE are incompletely understood. Based on repeated sampling of human skeletal muscle, we show here that acute, repeated and interrupted RE induce dynamic changes of the protein landscape associated with the sarcomeric cytoskeleton. These changes correlate with changes in phosphorylation indicative of adaptation and deadaptation signaling footprints. Regulation mainly affects the protein network linked to the muscle maintenance protein BAG3, which includes mechanosensory proteins, small heat shock proteins, and a lipid droplet associated protein. All network components exhibit altered phosphorylation and increased cytoskeletal association after damaging RE. Moreover, network components cooperate to recognize strained skeletal muscle structures and mediate their degradation through chaperone-assisted selective autophagy (CASA). Our study thus identifies key regulators of skeletal muscle homeostasis in humans. - Source: PubMed
Publication date: 2026/07/28
Kuppusamy MaithreyanJacko DanielGupta YaminiSieger SandroSchaaf KirillMatijass MartinBersiner KätheZacher JonasBonini SaraCosenza-Contreras Miguelvan der Ven PeterBloch WilhelmFürst Dieter OWinter DominicHöhfeld JörgHuesgen Pitter FGehlert Sebastian - [This retracts the article DOI: 10.3727/096504017X15143731031009.]. - Source: PubMed
Publication date: 2026/07/16