Ask about this productRelated genes to: SERPINB5 Blocking Peptide
- Gene:
- SERPINB5 NIH gene
- Name:
- serpin family B member 5
- Previous symbol:
- PI5
- Synonyms:
- maspin
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-20
- Date modifiied:
- 2016-04-06
Related products to: SERPINB5 Blocking Peptide
Related articles to: SERPINB5 Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/10
Pu TianFeng RanranWang ChunruZhao Ye - Invasive lobular carcinoma (ILC) accounts for 15% of breast cancers and presents challenges such as chemotherapy resistance and poorer survival outcomes compared to other subtypes. While often managed similarly to invasive ductal carcinoma (IDC), ILC requires tailored approaches due to its distinct biology. Ferroptosis, an iron-dependent form of cell death, shows potential in overcoming therapeutic resistance but remains unexplored in ILC. This study aimed to identify ferroptosis-related molecular subtypes, develop a robust gene signature using machine learning, construct an integrated prognostic model, and uncover potential therapeutic targets for ILC. - Source: PubMed
Publication date: 2026/02/25
Liu JunjieLi XiaoqianLi ZiyanZhang RuiLi XiaoduoFeng KexuanZhang WeiHe JianjunZhang Huimin - Soft tissue defects and injuries, such as gingival recession, those requiring dermal tissue filling, and other indications, affect millions worldwide, yet autologous grafting remains the standard of care in most instances, despite donor site morbidity and limited tissue availability. Tissue-engineered alternatives have strong potential to overcome these limitations. We evaluated an 8 mm-diameter, 1 mm-thick layered electrospun composite formed from polar/hydrophobic/ionic polyurethane with methacrylated gelatin (FD-PHI) and polycarbonate urethane (PCNU), seeded with a co-culture of human adipose-derived stem cells (ASCs) and microvascular endothelial cells (HAMVECs). A 1:2 HAMVEC:ASC ratio supported interconnected CD31 network formation and upregulated key proangiogenic factors (e.g., artemin, IL-1β, CXCL16, Serpin B5, leptin) after 7 days in vitro. Constructs were implanted subcutaneously into immunocompromised rats. Both cellular and acellular layered grafts integrated with the host tissue, aided by interlayer spacing facilitating tissue infiltration; however, cellular constructs exhibited significantly greater vessel density and diameter at 90 days. Pro-angiogenic proteins such as TGFBI, ITGAV, THY1, and PARVA were upregulated at early timepoints, which subsided over time, suggesting that a temporary upregulation may be sufficient to induce long-term outcomes for vascular function. Further proteomic analysis of the explants revealed an upregulation of laminin and collagen VI expression in cellular grafts, suggesting enhanced support for the development of the basement membrane. The work successfully shows the fabrication of a fully autologous EC and fibroblast-like co-culture, from a single adipose sample. This work holds promise as an alternative to current autologous grafting techniques, while overcoming challenges in preparing clinically applicable co-cultures. - Source: PubMed
Publication date: 2026/02/10
Webb Brian C WTran GenevieDevaraj KirtanaLindsay EmmaKuzmanov UrosGramolini Anthony OHofer Stefan O PSanterre J Paul - RNA 5-methylcytosine (mC) plays a critical role in cancer, yet its functional mechanisms and therapeutic relevance in cervical cancer remain unclear. Here, we generate the first base-resolution mC transcriptome maps in cervical cancer, revealing globally elevated mC levels in tumors. By integrating spatial transcriptomics and single-cell RNA-seq, we identify SERPINB5 as a novel mC-regulated oncogenic effector. mC modification enhances SERPINB5 mRNA stability and protein expression, promoting tumor growth, metastasis, and resistance to microtubule-targeting chemotherapeutics. Mechanistically, SERPINB5 upregulates mitotic regulators and microtubule motor proteins, including CENPE, enhancing mitotic progression and counteracting drug-induced mitotic arrest. Loss-of-function experiments demonstrate that SERPINB5 depletion sensitizes cervical cancer cells to paclitaxel and vincristine, while its reintroduction restores chemoresistance even in mC-deficient cells. Our study uncovers a previously unrecognized mC-SERPINB5 axis as a central driver of cervical cancer malignancy and chemoresistance, highlighting SERPINB5 as a clinically actionable target to improve outcomes for patients receiving microtubule-targeting chemotherapy. - Source: PubMed
Publication date: 2026/02/11
Liu JiejieZhou LiminYao PeipeiZhang NanGuo XiaoChen FeiYang ShiminDu XinWang HongyunZhou YouChen YuZhou Li - : Pancreatic adenocarcinoma (PAAD), often referred to as the "king of cancers," remains poorly understood in terms of the regulatory mechanisms involving brown adipocytes (BAs). : Bioinformatics approaches were employed to explore the role of BAs in PAAD progression, utilizing transcriptomic data from public databases. Prognostic genes were identified through differential expression analysis, univariate Cox regression, and machine learning. A risk model categorizing patients into high- and low-risk groups was developed, accompanied by a nomogram. Functional analysis, immune microenvironment profiling, somatic mutation analysis, and drug sensitivity testing were performed, with further validation via gene localization, immunohistochemistry, and clinical sample analysis. : Six prognostic genes (, , , , , and ) were identified, with the model and nomogram exhibiting robust predictive performance. Notable differences between the high- and low-risk groups were found in immune pathways, cell infiltration, tumor mutational burden, and drug sensitivity (e.g., axitinib). : , , and were highly expressed in PAAD samples, providing new insights into potential therapeutic strategies in PAAD treatment. - Source: PubMed
Publication date: 2025/12/31
Kang BinWang WeinaGuo XinBai TongLv ChengyuShen Yunzhi