Ask about this productRelated genes to: TRIM43 Blocking Peptide
- Gene:
- TRIM43 NIH gene
- Name:
- tripartite motif containing 43
- Previous symbol:
- -
- Synonyms:
- TRIM43A
- Chromosome:
- 2q11.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-03
- Date modifiied:
- 2016-10-05
Related products to: TRIM43 Blocking Peptide
Related articles to: TRIM43 Blocking Peptide
- How do transcriptomics vary in haploid human androgenote embryos at single cell level in the first four cell cycles of embryo development? - Source: PubMed
Vendrell Xde Castro PEscrich LGrau NGonzalez-Martin RQuiñonero AEscribá M JDomínguez F - Upon fertilization, oocytes transform into totipotent and pluripotent cleavage stage cells through the maternal-to-zygotic transition (MZT), which is regulated by maternal factors and zygotic genome activation (ZGA). Here, we investigated the in vivo function of 16 genes expressed with strong biases in oocytes and cleavage stage embryos by generating knockout (KO) mice. These MZT-associated genes are conserved across many mammalian species and include five multicopy gene family genes: the Nlrp9, Khdc1, Rfpl4, Trim43, and Zscan5 genes. Intercrosses between female KO and male KO mice, including Nlrp9a/b/c triple KO (TKO), Khdc1a/b/c TKO, Rfpl4a/b double KO (DKO), Trim43a/b/c TKO, and Zscan5b KO mice led to the birth to healthy offspring that in turn produced healthy offspring. Our study not only demonstrated that these MZT-associated genes are not essential for mouse development, but also provides valuable resources for analyzing the functions of these genes in other genetic backgrounds, in the presence of stressors, and under pathogenic conditions. - Source: PubMed
Publication date: 2020/11/06
Wakabayashi MizukiTamura ShioriKanzaki SatokoKosugi MayukoYoshimura YukiIto ToshiakiNagata KeiSato KazuhaTakada ShujiSekita YoichiKimura Tohru - Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral replication by regulating the structure of host cell centrosomes and thereby nuclear lamina integrity. Through RNAi screening we identified several TRIM proteins, including TRIM43, that control the reactivation of Kaposi's sarcoma-associated herpesvirus. TRIM43 was distinguished by its ability to restrict a broad range of herpesviruses and its profound upregulation during herpesvirus infection as part of a germline-specific transcriptional program mediated by the transcription factor DUX4. TRIM43 ubiquitinates the centrosomal protein pericentrin, thereby targeting it for proteasomal degradation, which subsequently leads to alterations of the nuclear lamina that repress active viral chromatin states. Our study identifies a role of the TRIM43-pericentrin-lamin axis in intrinsic immunity, which may be targeted for therapeutic intervention against herpesviral infections. - Source: PubMed
Publication date: 2018/11/12
Full Florianvan Gent MichielSparrer Konstantin M JChiang CindyZurenski Matthew AScherer MyriamBrockmeyer Norbert HHeinzerling LucieStürzl MichaelKorn KlausStamminger ThomasEnsser ArminGack Michaela U - Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent adult muscular dystrophies. The common clinical signs usually appear during the second decade of life but when the first molecular dysregulations occur is still unknown. Our aim was to determine whether molecular dysregulations can be identified during FSHD fetal muscle development. We compared muscle biopsies derived from FSHD1 fetuses and the cells derived from some of these biopsies with biopsies and cells derived from control fetuses. We mainly focus on DUX4 isoform expression because the expression of DUX4 has been confirmed in both FSHD cells and biopsies by several laboratories. We measured DUX4 isoform expression by using qRT-PCR in fetal FSHD1 myotubes treated or not with an shRNA directed against DUX4 mRNA. We also analyzed DUX4 downstream target gene expression in myotubes and fetal or adult FSHD1 and control quadriceps biopsies. We show that both DUX4-FL isoforms are already expressed in FSHD1 myotubes. Interestingly, DUX4-FL expression level is much lower in trapezius than in quadriceps myotubes, which is confirmed by the level of expression of DUX4 downstream genes. We observed that TRIM43 and MBD3L2 are already overexpressed in FSHD1 fetal quadriceps biopsies, at similar levels to those observed in adult FSHD1 quadriceps biopsies. These results indicate that molecular markers of the disease are already expressed during fetal life, thus opening a new field of investigation for mechanisms leading to FSHD. - Source: PubMed
Publication date: 2013/08/20
Ferreboeuf MaximeMariot VirginieBessières BettinaVasiljevic AlexandreAttié-Bitach TaniaCollardeau SophieMorere JuliaRoche StéphaneMagdinier FrédériqueRobin-Ducellier JérômeRameau PhilippeWhalen SandraDesnuelle ClaudeSacconi SabrinaMouly VincentButler-Browne GillianDumonceaux Julie - We describe the identification and characterization of Trim43a, Trim43b, and Trim43c genes, whose expression are restricted to preimplantation stages and peak at the 8-cell to morula stage. We identified a 5kb DNA fragment that covers upstream region of Trim43a as a putative promoter, which can drive the expression of mStrawberry fluorescent protein in a manner similar to endogenous Trim43 genes. Trim43 genes will be useful stage-specific markers for the study of preimplantation embryos. - Source: PubMed
Publication date: 2009/08/22
Stanghellini IlariaFalco GeppinoLee Sung-LimMonti ManuelaKo Minoru S H