Ask about this productRelated genes to: GLRX5 Blocking Peptide
- Gene:
- GLRX5 NIH gene
- Name:
- glutaredoxin 5
- Previous symbol:
- C14orf87
- Synonyms:
- PR01238, GRX5
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-18
- Date modifiied:
- 2016-10-05
Related products to: GLRX5 Blocking Peptide
Related articles to: GLRX5 Blocking Peptide
- Investigate the function of glutathione reductase-associated protein 5 (GLRX5) and its prognostic significance, as well as its association with CAFs and the TME. - Source: PubMed
Publication date: 2026/01/02
Wang YiniLiu HongquanWang TianqiYang YingyingMa XiaohongWu Jitao - Systemic juvenile idiopathic arthritis (sJIA) represents the most severe subtype of juvenile idiopathic arthritis and is classified as a rare autoinflammatory disease. It significantly impacts patients' quality of life. Its pathogenesis involves complex immune dysregulation and inflammatory responses, which remain incompletely understood. This study aims to identify key core genes associated with sJIA using advanced machine learning algorithms and construct an efficient diagnostic model. - Source: PubMed
Chen QifanZeng JiaxingTang HaijunSun YuWu HanhuaHuang XinyuMan Yu-NanLi BufanHe Mao-Lin - Dysregulated ISC metabolism has been implicated in cancer progression, but its role in LUAD pathogenesis and therapeutic targeting remains poorly understood. Here, we demonstrate that ISC biogenesis is significantly upregulated in LUAD, driven by transcription factors KLF15 and ZNF384, which activate GLRX5, LYRM4, NFS1 and BOLA3 promoters. IL-1β promotes PCAF mitochondrial translocation, releasing EP300 to amplify KLF15/ZNF384-mediated transcriptional activation. The natural monoterpenoid Hinokitiol inhibits LUAD growth by disrupting EP300-KLF15/ZNF384 interactions, suppressing ISC biogenesis gene expression and inducing ferroptosis. Mechanistically, the membrane protein TMDD1, particularly its cytoplasmic domain, promotes Hinokitiol's anti-tumor effects by facilitating EP300-KLF15/ZNF384 dissociation and inhibiting ISC biogenesis. Remarkably, Hinokitiol exhibits stage-dependent efficacy, with superior suppression of metastatic (stage IV) tumors linked to heightened ferroptosis sensitivity. This study not only elucidates the transcriptional machinery governing ISC biogenesis in LUAD but also highlights Hinokitiol's dual mechanism as a promising stage-specific therapeutic agent, offering novel strategies for advanced disease management. - Source: PubMed
Publication date: 2025/09/18
Kuang YanbinYang SuyangTian XiaotingCheng HuiyanLiu BeibeiZhang CongcongHan BaohuiZhang WeiZhang XiaoLou Yuqing - Osteoarthritis (OA) has been implicated in the development and progression of early-stage endometrial cancer (EC), suggesting shared pathogenic factors between the two diseases. This study aimed to investigate the causal relationship between OA and EC and to identify causative genes common to both early-stage EC and OA. A Two-sample Mendelian randomization (MR) analysis was first performed to assess the causal relationship between OA and EC. Differentially expressed genes associated with early-stage EC and OA were identified using the limma package. Overlapping genes were extracted to determine common causative genes, followed by enrichment analysis. The causal relationship between these genes and EC was verified through Mendelian randomization (MR) of drug targets. Genes with diagnostic value were identified using multiple machine learning algorithms to construct EC prediction models and evaluate their performance. Additionally, the study examined the correlation between diagnostic-value genes and immune cell infiltration. IVW analysis indicated that OA was a high-risk factor for the development of EC (P < 0.05). Seven common causative genes (CDKN2A, DDA1, LRRC42, POLB, ADCYAP1R1, DNMT3A, and GLRX5) were identified for OA and EC, showing significant enrichment in related pathways such as heterochromatin. MR analysis of drug targets revealed that CDKN2A, DDA1, LRRC42, and POLB had diagnostic value for EC. The EC prediction model based on these four genes demonstrated high performance (AUC = 0.974 for the training set; AUC = 0.966 for the validation set), and these genes were significantly associated with immune cell infiltration (P < 0.05). CDKN2A, DDA1, LRRC42, and POLB may be common causative genes for OA and early-stage EC, potentially serving as targets for drug intervention. - Source: PubMed
Publication date: 2025/07/01
Bai YiyunLuo SangShuai RuzhenZhang XiaomeiYuan LiweiLiu Dan - Atherosclerosis is a chronic, low-grade inflammatory disease affecting the arteries, which causes cardiovascular disease by narrowing the patient's arterial blood vessels, and is currently the number 1 disease killer in the United States. Nevertheless, developing new animal model approaches and novel therapeutic strategies requires time to treat affected individuals who do not benefit from statins. However, the exact mechanism behind AS pathology is still unknown. Mendelian Randomization based on summary data, Bayesian co-localization methods, and bioinformatics analyses were conducted for the integration of genome-wide association studies summary-level data on AS, expression quantitative trait locus (eQTL) study, and the FerrDb database related to the ferroptosis-associated genes in blood. The study exploited the eQTL data, which were obtained from 31,684 participants of mostly European ancestry from the eQTLGen consortium, the genome-wide association studies data from the FinnGen project (data freeze 10), included 51,589 AS cases and 343,079 controls. ATG7, SREBF1, GLRX5, and SRSF9 were found to be associated with ferroptosis-related gene targets in AS, as revealed by summary-data-based Mendelian randomization analysis. ATG7 and SREBF1 genes and the trait of atherosclerosis were influenced strongly by shared causal variation and co-localized as suggested by the co-localization analysis. Enrichment analysis was showed that these genes might be responsible to involved in the autophagy-related biological pathways and ferroptosis. Four key genes associated with ferroptosis in atherosclerosis were identified and can serve as the potential biomarkers for ferroptosis-associated pathways for the disease diagnostic and therapeutic purposes. There is a need to conduct further functional investigations in the future. - Source: PubMed
Li JuanNong JiaoHuang Xiao YanLiu QianLiu Yuan YuanSun Ji ChaoZhu Wan QingXie Sheng