Ask about this productRelated genes to: PDGFD Blocking Peptide
- Gene:
- PDGFD NIH gene
- Name:
- platelet derived growth factor D
- Previous symbol:
- -
- Synonyms:
- SCDGF-B, MSTP036, IEGF
- Chromosome:
- 11q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-22
- Date modifiied:
- 2015-08-25
Related products to: PDGFD Blocking Peptide
Related articles to: PDGFD Blocking Peptide
- Platelet-derived growth factors (PDGFs) and their cognate receptors (PDGFRα/β) play critical roles in breast cancer progression and metastasis. This review summarizes current evidence of PDGF ligand and receptor expression patterns, oncogenic functions, prognostic significance and therapeutic targetability, with a specific focus on small molecule inhibition. PDGF-PDGFR signaling is known to contribute to epithelial to mesenchymal transition, cancer stem cell maintenance, desmoplasia, angiogenesis, and immune modulation. Additionally, the four PDGF ligands have distinct oncogenic functions. PDGFA and PDGFB have been implicated in breast cancer associated brain metastasis, while PDGFC has been shown to play a crucial role in fibroblast activation. PDGFD, while less studied, may activate epithelial to mesenchymal transition in breast cancer. High expression of PDGFA, PDGFB, PDGFC, and stromal PDGFRβ correlate with poor patient survival, highlighting their potential as candidate biomarkers. We specifically focus on evaluating current therapeutic strategies which target the PDGF-PDGFR axis, including neutralizing antibodies, aptamers, and small molecule inhibitors, which show preclinical promise but limited clinical success in breast cancer to date. We discuss future research directions with emphasis on identifying selective inhibitors, utilizing PDGF-PDGFR signaling components for patient stratification, and combination with immunotherapies. - Source: PubMed
Publication date: 2026/08/07
Reardon Jesse JMossing Alexis APackard Rebecca LShah SajitaSizemore Gina M - Dermatofibrosarcoma protuberans (DFSP) is a fibroblastic malignancy characterized in most cases by COL1A1::PDGFB fusion. Rare cases exhibit alternative rearrangements involving PDGFD. Here, we describe a female patient in her third decade of life who presented with a spindle cell proliferation on the shoulder. Expression of pan-TRK and S100, together with absence of PDGFB overexpression, supported an initial impression of NTRK-rearranged spindle cell tumor. However, molecular analysis revealed PDGFD rearrangement, and re-excision demonstrated classic DFSP morphology in the residual tumor. Our findings underscore the importance of continued consideration for DFSP in tumors with focal S100 expression. - Source: PubMed
Publication date: 2026/08/04
Podesta VeneziaChan May PRottmann DouglasHarms Kelly LHarms Paul W - Differentiating neoplastic proliferation from inflammatory fibrosis in peripheral nerve hypertrophy is critical. We report a patient with a neurofibromatosis type 1 (NF1) deletion exhibiting extreme diffuse nerve enlargement and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)-like autoimmunity. This study aims to elucidate the underlying endoneurial fibrotic mechanism, specifically focusing on the signaling networks between Schwann cells (SCs) and fibroblasts. - Source: PubMed
Publication date: 2026/07/17
Wang FeiCao WenqianLu JiayeHuang RunBai YuhanZhang YiningWang ZilanChen ZhouqingWang Zhong - Litter size is a key trait for evaluating reproductive performance of goats, which can directly influence the breeding efficiency and profitability of production cycles. However, a comprehensive understanding of its genetic architecture, including the causative mutations and their functional impacts, remains scarce, thus hindering its application in precision breed-ing. - Source: PubMed
Publication date: 2026/07/27
Feng DaHu SiyiMa JianDu ChunmeiZhou GuangxianWei ChenGan Shangquan - PDGFB or, more rarely, PDGFD rearrangements are well-established oncogenic drivers of dermatofibrosarcoma protuberans (DFSP). Recently, a TNC::PDGFD fusion has been identified in a superficial spindle cell tumor distinct from DFSP but similar to the tumor entity described as ossifying plexiform tumors of the skin. Herein, we report seven additional cases of cutaneous ossifying plexiform tumors harboring TNC::PDGFD fusion transcript. Four patients were female. Tumors were located on the nose (n=2), hand (n=2), forearm (=1), flank (n=1), and foot (n=1) with a median size of 6 mm (range: 4-9). Microscopically, these neoplasms were located in the dermis (n=6) and subcutaneous tissues (n=1). All specimens exhibited a lobulated architecture and a biphasic appearance, characterized by the association of cellular areas composed of bland spindle cells with central regions of bone formation. Immunohistochemistry showed SATB2 positivity in all tested tumors (n=4). RNA sequencing analysis confirmed the presence of a TNC::PDGFD fusion transcript in all cases and revealed a transcriptomic profile that was distinct from other soft tissue tumors, including DFSP. Our findings support that TNC::PDGFD is the oncogenic driver of ossifying plexiform tumor of the skin, a rare tumor distinct from DFSP. - Source: PubMed
Publication date: 2026/07/21
Ronen ShiraMeurgey AlexandraMichal MichaelPissaloux DanielTirode FranckBeatty Colleen JMacagno Nicolasde Pinieux GonzagueCassarino David SOrtonne NicolasLamant LaurenceCalonje EduardoTetzlaff MichaelLeBoit Philip EBillings Steven DKervarrec Thibault