Ask about this productRelated genes to: TIMP2 Blocking Peptide
- Gene:
- TIMP2 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 2
- Previous symbol:
- -
- Synonyms:
- CSC-21K
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-05
Related products to: TIMP2 Blocking Peptide
Related articles to: TIMP2 Blocking Peptide
- Fibroblast Activation Protein (FAP) is a key marker of Cancer-Associated Fibroblasts (CAFs) and a promising target for cancer theranostics. However, its expression in both stromal and tumor cells complicates therapeutic strategies. - Source: PubMed
Publication date: 2026/06/19
Tashireva Liubov AGrigoryeva Evgeniya SPatskan Ivan AKalinchuk Anna YuZelchan Roman V - Dysregulation of vascular smooth muscle cell (VSMC) function is a key factor in coronary heart disease (CHD) pathogenesis. This study investigates the role of miR-4443 in regulating VSMC behavior and its potential as a clinical biomarker. - Source: PubMed
Publication date: 2026/06/17
Sun RongguoHao JichunJia GuoweiLiu FeiSong Shutian - Fructose containing soft drinks worsen acute kidney injury (AKI) risk during simulated work related heat stress (WrHS), but the fructose content is comparatively lower in sport drinks. This study tested the hypothesis that consuming a higher-fructose sport drink exacerbates AKI risk compared to consuming a sucrose-sweetened sport drink during a four-hour WrHS simulation. In this block randomized, double-blind crossover study, 12 healthy adults (26±7 y; 6 women) completed two trials involving ingesting six 500 mL doses of a higher-fructose sport drink (55% fructose & 45% glucose; Fructose55) or a sucrose-sweetened sport drink (50% fructose & 50% glucose; Sucrose) before, during, and following a 4 hour WrHS simulation that comprised three circuits of treadmill walking (10 minutes) and rowing (5 minutes) at five metabolic equivalents and 15 minutes of rest every hour. Drinks were matched for total carbohydrates, calories, and electrolytes and modestly matched for osmolality. Urine and blood samples were collected pre- and post-exposure, at recovery, and 24 hours post-visit. AKI risk was quantified as the product of urine insulin-like growth factor-binding protein 7 and urine tissue inhibitor of metalloproteinase-2 ([IGFBP7•TIMP-2]) normalized to specific gravity. Peak rectal temperature (Fructose55: 38.3±0.7°C, Sucrose: 38.3±0.7°C, p=0.991) and percent change in body weight (Fructose55: -0.7±1.0%, Sucrose: -0.9±1.0%, p=0.466) were not different between trials. Urinary [IGFBP7•TIMP-2] increased over time (p<0.001) but did not differ between trials (peak change - Fructose55: 1.7±1.6 (ng/mL)2/1000, Sucrose: 1.6±1.8 (ng/mL)2/1000, p=0.677). Consuming a higher-fructose containing sport drink does not exacerbate AKI risk during WrHS when compared to a sucrose-sweetened equivalent. - Source: PubMed
Publication date: 2026/06/16
Tourula EricaHeikkinen Molly ERegester AmandaOwen Marley GHess Hayden WSpence LisaMickleborough Timothy DJohnson Blair DGletsu-Miller NanaSchlader Zachary J - Osteoarthritis (OA) remains an alarming therapeutic challenge, as conventional intra-articular interventions primarily address symptomatic relief without halting progressive cartilage and bone degeneration. In this study, we investigated the disease-modifying potential of Cyclo(His-Pro) (CHP) in a monosodium iodoacetate (MIA)-induced OA rat model. Intra-articular CHP yielded significant clinical improvements, reducing joint edema and reversing OA-induced mechanical and thermal hypersensitivity, as evidenced by lifting behavior, rotarod performance, and hot plate tests. Beyond analgesia, micro-computed tomography (micro-CT) analysis showed that CHP preserved subchondral bone architecture, restoring trabecular volume and thickness and reducing serum C-terminal telopeptide of type II collagen (CTX-2), indicative of suppressed cartilage degradation. At the molecular level, CHP reprogrammed the joint microenvironment by suppressing , , , , , and expression and decreasing systemic prostaglandin E2 (PGE) levels. Moreover, CHP showed efficacy comparable to Conjuran, a polynucleotide-based mechanical supportive agent, while additionally targeting COX-2/PGE-driven inflammatory cascades and cartilage catabolic pathways. Collectively, these findings indicate that intra-articular CHP confers combined analgesic, chondroprotective, and osteoprotective effects, supporting its potential as a promising disease-modifying osteoarthritis drug candidate. - Source: PubMed
Publication date: 2026/05/25
Huh GyuwonLee DohyunJeon JongsuKim DaehunJung Hoe-Yune - Despite effective combination antiretroviral therapy (cART), executive function impairment remains prevalent among people living with HIV (PLWH). The pathogenesis of HIV-associated neurocognitive disorder is multifactorial, involving chronic immune activation, metabolic alterations, and neuroinflammatory processes. Matrix metalloproteinases and their tissue inhibitors (TIMPs) contribute to neuroinflammation and blood-brain barrier disruption, but their relationship with executive dysfunction in HIV remains unclear. - Source: PubMed
Publication date: 2026/06/03
Weng Ya-WeiTsai Hung-ChinLee Susan Shin-JungHsu Chih-HuiLin Sheng-Hsiang