Ask about this productRelated genes to: GABRB2 Blocking Peptide
- Gene:
- GABRB2 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor beta2 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q34
- Locus Type:
- gene with protein product
- Date approved:
- 1994-04-29
- Date modifiied:
- 2016-02-04
Related products to: GABRB2 Blocking Peptide
Related articles to: GABRB2 Blocking Peptide
- Early childhood exposure to bisphenol A (BPA) is closely associated with autism spectrum disorder (ASD), though the precise molecular mechanisms remain unclear. To investigate this, we employed an integrated computational approach combining network toxicology, molecular docking, and molecular dynamics simulation. Potential targets of BPA and ASD-related genes were collected from multiple databases, identifying 57 overlapping targets. Protein-protein interaction network analysis highlighted 16 core targets among them. Gene Ontology and KEGG pathway enrichment analyses indicated these targets are primarily involved in synaptic transmission, GABAergic signaling, and neuroactive ligand-receptor interactions. Molecular docking demonstrated potential binding between BPA and several core targets, including estrogen receptor 1 (ESR1), gamma-aminobutyric acid type A receptor subunit beta-2 (GABRB2), and amyloid precursor protein (APP), with binding energies below -5 kcal/mol. The stability of the BPA-ESR1 complex was further supported through 100 ns molecular dynamics simulation. These results suggest that BPA may contribute to ASD by disrupting neuroendocrine pathways and synaptic function via interactions with key targets such as ESR1. - Source: PubMed
Publication date: 2026/07/16
Zheng GuanminWang LiyuWang GuoqiangZhang YuhangHan XueQiu GuoSun YangangPei LanyingWu SuhuiLi Hanbing - Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition with a well-characterised genetic architecture, yet how ASD-associated genes map onto discrete brain regions remains poorly understood. This study applied a recently validated analysis pipeline (ATLANTE) to discover regions of the human brain enriched for high expression of 234 high-confidence ASD-associated genes. Eleven discrete brain regions were identified, spanning cortical, limbic and cerebellar systems including the anterior orbitofrontal gyrus, cerebellar cortex, flocculonodular lobe, vermis, posterior cingulate cortex, temporo-occipital transitional zone, hippocampal subfields CA1 and CA3, postcentral gyrus, occipital cortex and perirhinal gyrus. Notably, the anterior orbitofrontal gyrus exhibited significant enrichment for syndromic ASD genes, suggesting a core role in the neuropsychiatric features of syndromic presentations. Network and community clustering analyses revealed three major gene communities corresponding to distinct biological processes: synaptic dysfunction in limbic regions, histone modification in cerebellar regions and axonal ion channel regulation in cortical regions. Nodal analysis identified eight high-priority genes with broad relevance across multiple brain regions, including NR3C2, GABRB2 and NBEA. These findings provide a refined neuroanatomical framework for ASD pathophysiology, identify understudied brain regional targets and imply that ASD-associated genes exert primary effects in specific brain regions. - Source: PubMed
Odierna G LorenzoBitsika VickiSharpley Christopher F - Dibutyl phthalate (DBP) and dibutyl adipate (DBA) are commonly used plasticizers that may pose risks to aquatic organisms. This study investigated whether DBP and DBA disrupt larval growth through neuroendocrine pathways using zebrafish (Danio rerio) as an in vivo model. Embryos were continuously exposed to DBP or DBA for 96 h, and growth-related morphological, transcriptional, and protein-level endpoints were assessed. DBP significantly reduced larval body length and increased locomotor activity, accompanied by decreased growth hormone (GH), insulin-like growth factor-1 (IGF-1), and gamma-aminobutyric acid-A (GABA) receptor alpha 2 protein levels, as well as marked suppression of gh1, igf1, gad2, gabrb2, and gabrg2 expression. DBA produced qualitatively similar but consistently weaker effects, primarily affecting growth endpoints and selected neuroendocrine markers. Continuous co-exposure with the GABA receptor antagonist bicuculline or the IGF-1 receptor inhibitor picropodophyllin did not further exacerbate growth inhibition or IGF signaling suppression compared with DBP or DBA exposure alone, revealing a non-additive interaction pattern. These findings suggest that DBP and DBA may impair larval growth through disruption of GABAergic and GH/IGF-related neuroendocrine regulation. Together, the results provide insight into the potential neuroendocrine mechanisms underlying plasticizer-induced developmental toxicity. - Source: PubMed
Publication date: 2026/07/13
Yun KijeongJeon SominLee InkyuKho YounglimJi Kyunghee - Cancer cells can acquire neuron-like characteristics ("neural mimicry") to promote progression. However, the role of specific ion channel genes in Papillary Thyroid Carcinoma (PTC) and their clinical significance remains unclear. - Source: PubMed
Publication date: 2026/06/22
Liu XinyuMei ChengjinTan JifengLiu YanlanLiu YuyaoZhou ZhigangZhao Jianfu - Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer; however, indeterminate cytology in fine-needle aspiration biopsy (FNAB) and the limited sensitivity of single-mutation-based biomarkers remain important clinical challenges. This study aimed to identify a robust multi-gene expression signature for diagnostic evaluation and exploratory prognostic assessment of PTC. An integrative bioinformatics framework was applied to TCGA-THCA RNA-sequencing data (505 tumors and 59 normal samples). Differentially expressed genes were subjected to LASSO regression to construct a diagnostic model, which was externally validated in two independent GEO cohorts (GSE33630 and GSE60542). A seven-gene signature consisting of four upregulated genes (GABRB2, SERINC2, PTCHD4, HAPLN1) and three downregulated genes (SLC6A15, UGT2B11, GRIA1) demonstrated excellent diagnostic performance in the discovery cohort (AUC = 0.995) and remained highly accurate in external validation datasets (AUC = 0.940 and 0.938). Kaplan-Meier analysis showed significant stratification for disease-free interval (p = 0.034), although this association did not remain independent in multivariable analysis. Exploratory analyses suggested potential epigenetic regulation of several genes and distinct patterns in immune microenvironments between risk groups. Overall, these findings reveal a robust seven-gene expression signature with strong diagnostic capacity and potential prognostic relevance in PTC, highlighting its value for molecular characterization. However, further biological validation and prospective evaluation in clinically relevant cohorts are required before translational applicability can be established. - Source: PubMed
Publication date: 2026/06/21
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