Ask about this productRelated genes to: ZBTB38 Blocking Peptide
- Gene:
- ZBTB38 NIH gene
- Name:
- zinc finger and BTB domain containing 38
- Previous symbol:
- -
- Synonyms:
- FLJ35036, CIBZ, ZNF921, PPP1R171
- Chromosome:
- 3q23
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-12
- Date modifiied:
- 2015-08-26
Related products to: ZBTB38 Blocking Peptide
Related articles to: ZBTB38 Blocking Peptide
- Methylation of cytosine bases in the CpG context (mCpG) is an essential regulatory mechanism cells use to spatially and temporally orchestrate access to genomic regions and mediate transcription. In many diseases, DNA methylation patterns become inappropriately distributed leading to aberrant transcriptional outcomes. Methyl-CpG binding proteins (MBPs) are key epigenetic mediators that selectively recognize mCpG sites, translating these signals into discrete transcriptional responses. ZBTB38 is a zinc finger (ZF) MBP that uniquely harbors two sets of five ZF clusters; each capable of selectively distinguishing mCpG sites. While the cognate DNA sequence and molecular basis for selective mCpG recognition have been defined for the ZBTB38 C-terminal (C-term) ZF domain, the molecular basis for differentiating DNA targets by the N-terminal (N-term) ZF domain remained uncharacterized. Here we report the mCpG-containing consensus sequence for the ZBTB38 N-term ZFs and demonstrate that unlike the other two ZBTB MBP family members ZBTB33 (Kaiso) and ZBTB4, the three shared core ZF domain discriminates against binding to TpG-containing DNA, and that at least one additional N-term ZF is required to stabilize DNA engagement. In addition, we demonstrate that each ZBTB38 ZF domain exhibits preferential target recognition for their respective cognate methylated DNA consensus motif. These findings expand understanding for how ZBTB38 differentially mediates epigenetic-based transcriptional process in normal and disease-state cells by providing new insight into the molecular basis by which the ZBTB38 N-term ZF domain differentiates DNA targets and offering further insight into the interplay between the N- and C-term ZF domains in directing cellular activities. - Source: PubMed
Publication date: 2026/05/07
Boster JaredGangi CooperHudson Nicholas OBillings Dallin EGuerra Castañaza Jenkins Brandon LeonelDing Victoria LBuck Bethany A - BACKGROUND: Embryonic muscle development is a highly dynamic and complex process, coordinated by numerous genes and transcriptional regulators such as small RNAs. RESULTS: Here, we profiled transcriptomic dynamics in breast muscle from Arbor Acres (AA) broilers and TaoYuan (TY) chickens at three embryonic time points (E9, E13, and E18). While developmentally regulated genes enriched similar biological pathways in both breeds, the architecture of microRNA (miRNA)-mRNA interaction networks was distinct. Integrative analysis combining weighted gene co-expression network analysis, differential expression analysis, and time-series clustering identified 161 candidate genes, including a subset of 39 showing progressively decreasing expression. Differential expression analysis of miRNA revealed that gga-miR-1744-3p was uniquely up regulated at E13 and E18 in TY chickens. By integrating predictions from TargetScan and miRDB, we further identified two core genes (USP8 and ZBTB38) from the set of 39 candidate genes, which are predicted targets of gga-miR-1744-3p. This gene was differentially expressed in the heart, breast muscle, and adipose tissue, and exhibited significantly higher expression in TY chickens. Functional assays confirmed that gga-miR-1744-3p promotes proliferation of chicken primary myoblasts. CONCLUSIONS: This study provides a comprehensive understanding of the development patterns and molecular mechanisms of breast muscles in broilers during embryogenesis. - Source: PubMed
Publication date: 2026/04/06
Zhao DiShi YifanOuyang QingyuanZhang HaihanGuo YumingSong ZeheHe Xi - Circular RNAs (circRNAs) hold significant potential both in the regulation of tumor progression and in clinical applications for tumors. This study aims to investigate the functional mechanism of circ-ZBTB38 in melanoma progression as well as its potential clinical application value. - Source: PubMed
Publication date: 2026/03/28
Zhang WanqiYang NanWang YuekaiLi XinyingTan LiuchangLi HongliLu Yuangang - Persistently infected (PI) calves resulting from maternal Bovine viral diarrhea virus (BVDV) infection during early gestation are the main source of viral transmission and pose a serious threat to the sustainable production of herds. PI cattle appear clinically normal, elucidating the molecular-level alterations is critical for understanding their specific characteristics. Moreover, the identification of candidate biomarkers for diagnosing PI cattle will provide valuable insights to support effective strategies for the control and eventual eradication of BVDV. At the same time, few studies have focused on the mothers of PI calves (Trojan dam). - Source: PubMed
Publication date: 2026/03/10
Wang JiahaoChen SiqianLai WanyiFeng XiaoZhao QingyaoMi SiyuanXu ChuangQin TongCao JieYu Ying - The X-linked inhibitor of apoptosis protein (XIAP) is a key suppressor of apoptosis, crucial for cellular differentiation, embryogenesis, and cancer progression. However, its upstream regulatory mechanisms remain poorly understood. Here, we demonstrate that the zinc finger transcription factor Zbtb38, a negative regulator of apoptosis, modulates XIAP expression in both loss- and gain-of-function experiments, irrespective of p53 expression. Notably, XIAP overexpression rescues the apoptosis induced by Zbtb38 knockdown, indicating that Zbtb38-associated apoptosis is at least partially XIAP-dependent. Mechanistically, Zbtb38 binds to E-box motifs within upstream regulatory regions of XIAP and activates its transcription. During embryonic stem cell differentiation and embryogenesis, Zbtb38 depletion increases apoptosis and reduces XIAP and Bcl-2 expression, underscoring their functional relevance in these processes. Analysis of human tumor datasets reveals a strong positive correlation between ZBTB38 and XIAP expression, with elevated ZBTB38 levels associated with high-grade malignancies. Furthermore, Zbtb38 knockdown induces apoptosis in cancer cells with reduced XIAP expression, regardless of p53 expression. Collectively, these findings uncover a novel Zbtb38-XIAP axis that regulates apoptosis during cellular differentiation, development, and oncogenesis and highlight its therapeutic potential in XIAP-driven and p53-deficient tumors. - Source: PubMed
Shigeoka ToshiakiNagaoka HiroyukiNurulita Nunuk AriesTada ShogoBessho YasumasaIshida YasumasaMatsuda Eishou