Ask about this productRelated genes to: LONRF1 Blocking Peptide
- Gene:
- LONRF1 NIH gene
- Name:
- LON peptidase N-terminal domain and ring finger 1
- Previous symbol:
- -
- Synonyms:
- FLJ23749, RNF191
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-19
- Date modifiied:
- 2015-08-25
Related products to: LONRF1 Blocking Peptide
Related articles to: LONRF1 Blocking Peptide
- 1. Double digest restriction site-associated DNA sequencing (ddRADseq) data were utilised to perform genome-wide scanning for selection signatures within Denizli (DNZ) and Gerze (GRZ) by a combination of runs of homozygosity (ROH) and Tajima's D index. The genome of native Anatolian chicken breeds was compared to commercial broiler (BROHIB) and layer (LAYHIB) lines the approach to identify genomic regions associated with economically important traits.2. Tajima's D index-based selection signatures were detected in 269 and 772 single nucleotide polymorphisms (SNP) in DNZ and GRZ breeds, respectively, overlapped with 32 and 58 protein-coding genes. These genes were positioned within a ROH island, which indicated their fixation across the population.3. A literature review confirmed that numerous genes under selection in Anatolian chicken breeds were associated with environmental adaptation. These included thermo-tolerance ( and ), pathogen and disease resistance ( and ) as well as survival traits including hearing (), vocal learning (), vision ( and ) and reaction to fear (). The results of comparative analysis revealed 10 ( and ) and three ( and ) genes common in native Anatolian chicken breeds and commercial hybrid lines implying that they are likely to affect economically important traits.4.This study confirmed that the genome of native Anatolian chicken breeds has been shaped by natural selection in response to adverse environmental conditions. Among detected genes, seems promising for explaining the genetic underpinnings of the long crowing characteristics of the DNZ breed since it is linked to vocalisation and learning ability in avian species. - Source: PubMed
Publication date: 2025/07/25
Demir EArgun Karsli BÖzdemir DBilginer UDoğru HKaya SAtmaca VTufan NDemir EKarslı T - Randall's plaque (RP) is recognized as a precursor lesion for kidney stones, with its formation and progression potentially linked to oxidative stress. Previous studies have provided limited insights into the underlying mechanisms of RP, failing to fully elucidate its molecular pathways. To investigate the relationship between oxidative stress and RP, we employed bioinformatics approaches to identify key genes, predict associated pathways and drug molecules, analyze variations in immune cell populations, and construct diagnostic models. We initially identified three differentially expressed genes related to oxidative stress: BFSP1, LONF1, and TAF1D. These genes and their co-expressed counterparts are enriched in pathways related to oxidative phosphorylation, cellular adhesion processes, steroid hormone biosynthesis, and autophagy. Furthermore, we observed significant differences in two types of immune cells across the study groups. Ultimately, predictions from drug molecular docking suggest that BFSP1 may serve as a promising therapeutic target for RP. We propose that the formation of RP mediated by oxidative stress could be associated with BFSP1, LONF1, TAF1D along with CD56dim natural killer cells and memory B cells. Thus far, BFSP1 emerges as a pivotal therapeutic target for RP development. These findings offer new perspectives on the mechanisms underlying the pathogenesis of RP. - Source: PubMed
Publication date: 2024/12/28
Li FanShi KeLi SongchaoWei YanJia Zhankui - This study explores the role of disulfidptosis in monocytes and its relation to postmenopausal osteoporosis (PMOP). Using single-cell RNA sequencing and microarray assays, we identified key genes: LONRF1, ACAP2, IPO9, and PGRMC2. Through differential analysis, Weighted Gene Co-expression Network Analysis (WGCNA), and machine learning, these genes were linked to PMOP. Functional enrichment and ROC curve analysis demonstrated their effectiveness in distinguishing postmenopausal fracture patients from healthy individuals. Notably, PGRMC2 exhibited significant expression differences, highlighted by a notable Area Under the Curve (AUC) value of 0.665. Further investigation involved Western blotting and immunohistochemical assays, revealing decreased PGRMC2 expression in ovariectomized (OVX) mice. This decrease was consistent across both experimental methods, emphasizing PGRMC2's role in PMOP. Moreover, PGRMC2 was predominantly present in macrophages compared to monocytes within bone tissue and was significantly located in bone marrow mesenchymal stem cells (BM-MSCs) in PMOP patients. It was also abundantly found in osteoblasts and adipocytes. Additionally, a Mendelian randomization analysis using the TwoSampleMR R package, with data from decode and GWAS databases, was conducted. This analysis showed a significant impact of PGRMC2 on osteoporosis risk (p = 0.0048, OR = 0.6836), suggesting a potential protective effect against the disease. Our results suggest that PGRMC2 may facilitate the differentiation of monocytes into macrophages in bone tissue, influencing the behavior of BM-MSCs. This, in turn, could impact the progression and severity of PMOP. The study provides new insights into the molecular mechanisms underlying postmenopausal osteoporosis and highlights the potential of PGRMC2 as a therapeutic target or biomarker for this condition. - Source: PubMed
Publication date: 2024/08/19
Wang YaobinXiao HefangChen YiSheng XiaoyunFeng ZhiweiPeng BoLiu ZhongchengZhan HongweiXiang DejianZhang ChengjunXia YayiGeng Bin - The LONRF family of proteins consists of three isozymes, LONRF1-3, which harbors RING (really interesting new gene) domain and Lon substrate binding domain. We have recently identified LONRF2 as a protein quality control ubiquitin ligase that acts predominantly in neurons. LONRF2 selectively ubiquitylates misfolded or damaged proteins for degradation. LONRF2-/- mice exhibit late-onset neurological deficits. However, the physiological implications of other LONRF isozymes remain unclear. Here, we analysed Lonrf1 expression and transcriptomics at the single-cell level under normal and pathological conditions. We found that Lonrf1 was ubiquitously expressed in different tissues. Its expression in LSEC and Kupffer cells increased with age in the liver. Lonrf1high Kupffer cells showed activation of regulatory pathways of peptidase activity. In normal and NASH (nonalcoholic steatohepatitis) liver, Lonrf1high LSECs showed activation of NF-kB and p53 pathways and suppression of IFNa, IFNg and proteasome signalling independent of p16 expression. During wound healing, Lonrf1high/p16low fibroblasts showed activation of cell growth and suppression of TGFb and BMP (bone morphogenetic protein) signalling, whereas Lonrf1high/p16high fibroblasts showed activation of WNT (wingless and Int-1) signalling. These results suggest that although Lonrf1 does not seem to be associated with senescence induction and phenotypes, LONRF1 may play a key role in linking oxidative damage responses and tissue remodelling during wound healing in different modes in senescent and nonsenescent cells. - Source: PubMed
Li DanWang Teh-WeiAratani SaeOmori SatotakaTamatani MahoJohmura YoshikazuNakanishi Makoto - Prostate cancer (PCa) is a malignant neoplasm of the urinary system. This study aimed to use bioinformatics to screen for core genes and biological pathways related to PCa. - Source: PubMed
Guo HanxuZhang ZhichaoWang YuhangXue Sheng