Ask about this productRelated genes to: UBE2E3 Blocking Peptide
- Gene:
- UBE2E3 NIH gene
- Name:
- ubiquitin conjugating enzyme E2 E3
- Previous symbol:
- -
- Synonyms:
- UbcH9
- Chromosome:
- 2q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-01
- Date modifiied:
- 2016-03-14
Related products to: UBE2E3 Blocking Peptide
Related articles to: UBE2E3 Blocking Peptide
- Integrin beta 4 (ITGB4) has been implicated in breast cancer progression, yet its clinical utility as a biomarker remains unclear due to inconsistent findings across studies. This discrepancy may stem from the failure to distinguish between RNA and protein levels. - Source: PubMed
Zhu Zhi-MinHu LeiMa Yan-WenZhu Qiong-Ni - The process of domestication in ducks has led to distinct morphological, behavioral, and physiological traits that differentiate from their wild ancestors. Among these traits, reproductive performance, particularly egg production, has been specifically enhanced. In this study, in order to understand the molecular mechanisms underlying the great differences of egg production between domesticated ducks and their wild ancestors, we integrated genomic and transcriptomic analyses to identify candidate genes and pathways associated with egg production. Selective sweep analyses based on Di revealed genomic regions under selection in multiple egg-type duck breeds. A total of 987 candidate genes were identified, with 11 genes shared across breeds, suggesting common selection pressures. Transcriptomic analyses between egg-type ducks and mallard revealed differentially expressed genes involved in hormone regulation, lipid transport, and follicular development in the liver and gonads. Multiple candidate genes (such as FN1, PDE10A, SEMA5B, UBE2E3) and enriched pathways (such as ECM-receptor interaction, Wnt signaling, steroid hormone biosynthesis) were found to be potentially linked to egg production traits. Notably, only FN1 and SEMA5B were identified by both genomic and transcriptomic analyses. Our study provide additional insights into the genetic basis of egg production in ducks. - Source: PubMed
Publication date: 2026/02/12
Zhang XinyeZhao XiurongGu HongchangZhu TaoSun HongyanZhang YalanWang GangRen XufangChen AnqiJiang XiaoyuQu Lujiang - To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses. - Source: PubMed
Publication date: 2026/01/02
Lama JyotiLiu ReneeHuerta-Chagoya AliciaLi AshleyHuynh KatieStanwyck Lynn KHan SamuelZhao YanChan WeilinChen LiyinMukundan AnanyaMeng DaYang Janine YSusarla GayatriSang DeliaPapaliodis George NShen Lucy QRossin ElizabethElkins ChristineBenavides IrmaWafapoor HusseinCutino AntonioWiggs Janey LEaton Alexander MSegrè Ayellet VSobrin Lucia - Individuals with bipolar disorder (BD) exhibit a significantly increased risk of cardiovascular disease, yet the specific mechanisms linking heart failure (HF) and BD remain poorly understood. This study aimed to identify common potential diagnostic biomarkers associated with both conditions. - Source: PubMed
Publication date: 2025/09/10
Zhang WeiLi Na - MicroRNAs (miRNAs) play an increasingly recognized role in modulating cancer development. Due to their function in regulating gene expression, miRNAs can suppress or promote tumorigenesis. miR-379-5p expression is downregulated in multiple human cancers, including breast and bladder cancers. However, the mRNAs targeted by miR-379-5p that promote cancer development have not been fully identified. Our goal was to identify a gene whose expression is regulated by miR-379-5p, and which may contribute to cancer development in cells where miR-379-5p expression is reduced. Bioinformatics analysis showed the UBE2E3 ubiquitin conjugating enzyme gene to be a potential target for miR-379-5p. To verify that UBE2E3 is a target, we transfected normal human epithelial mammary cells and breast adenocarcinoma cell lines with a miR-379-5p mimic. The mimic reduced UBE2E3 mRNA and protein levels, as would be predicted for a miR-379-5p target. To determine if UBE2E3 is a direct target of miR-379-5p, we engineered two luciferase reporter gene constructs to contain either a wild-type putative miR-379-5p binding sequence isolated from the 3'UTR of the UBE2E3 gene, or a scrambled sequence. The luciferase assay showed that the miR-379-5p mimic suppressed luciferase activity for the WT binding sequence reporter, but not for the scrambled reporter, showing that the effect of miR-379-5p on UBE2E3 expression is likely to be direct. Finally, to determine if the effect of miR-379-5p on UBE2E3 is related to cellular behaviors that play a role in cancer development, we measured cell viability by resazurin assay, cell proliferation by BrdU assay, and apoptosis by caspase 3/7 activation assay. The miR-379-5p mimic and silencing UBE2E3 expression both resulted in significantly diminished cell viability, while silencing UBE2E3 demonstrated both higher proliferation and apoptotic rates. Overall, these results suggest that while the overall effect of miR-379-5p is to inhibit breast cell viability and proliferation, the effect of silencing its target UBE2E3 is more complex because it induces both cell proliferation and apoptosis. - Source: PubMed
Publication date: 2024/12/02
Schroder Araya KLoy Conor JAiala FernandaRafique JazmynGhosh ArnobYoo Lina I