Ask about this productRelated genes to: ITGB1BP2 Blocking Peptide
- Gene:
- ITGB1BP2 NIH gene
- Name:
- integrin subunit beta 1 binding protein 2
- Previous symbol:
- -
- Synonyms:
- CHORDC3
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-11
- Date modifiied:
- 2016-10-05
Related products to: ITGB1BP2 Blocking Peptide
Related articles to: ITGB1BP2 Blocking Peptide
- To characterize the prenatal sonographic features across different trimesters and genomic spectrum of NONO-related X-linked intellectual developmental disorder. - Source: PubMed
Publication date: 2026/02/18
Zhao YilinZou GangShi MengmengLaw Kwok MingLau So LingMeng MengTing Yuen HaPoon Chiu Yee LionaDong ZiruiChau Matthew Hoi KinLeung Tak YeungChoy Kwong WaiZhang XinwenCao Ye - Previous studies have shown that regular physical activity combined with the use of the superfood NBS supplement can reduce the cardiac damage caused by methamphetamine. However, the genetic mechanisms affecting apoptosis in the myocardium affected by these methods have not been fully identified. The aim of this research was to examine the impact of aerobic training and NBS superfood intake on apoptosis and cardiac damage in methamphetamine- withdrawn rats. 104 male Wistar rats were randomly assigned to eight distinct groups. Methamphetamine was given intraperitoneally at a dose of 10 mg/kg twice a day during the first week. The dosage was then steadily raised by 1 mg/kg every week from the second to the sixth week. The training plan included five days a week, 60 min of moderate-intensity treadmill aerobic training across six weeks. Moreover, for a duration of 45 days, the NBS Superfood supplement was given daily at a dose of 25 g/kg. Myocardial sampling was performed to measure the levels of Melusin and caspase-3 gene transcripts, while blood serum analysis was performed to examine the concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH) enzymes. Data analysis utilized a one-way analysis of variance (p ≤ 0.05). The results show that methamphetamine use greatly raised caspase-3 gene expression as well as CK and LDH levels while simultaneously lowering Melusin gene expression (p ≤ 0.05). Furthermore, lowering serum CK and LDH levels, enhancing Melusin gene expression, and lowering caspase-3 gene expression were all accomplished through aerobic training, nutritional supplementation, and the synergistic intervention (p 0.05). The results of the study showed that the combined intervention (training and supplementation) had better effects than the single intervention (exercise alone or supplementation alone). This was manifested in a significant decrease in caspase-3 levels and a significant increase in Melusin expression. The results of this study indicate that combining endurance training with the NBS Superfood supplement NBS can modulate genetic changes associated with methamphetamine-induced cell death and myocardial damage. This combined approach can be proposed as a novel method for addiction cessation in animal studies that can pave the way for future research in human populations. - Source: PubMed
Publication date: 2025/10/23
Kordi NeginAzizi MohammadSamadi MohammadTahmasebi Worya - Cardiovascular diseases (CVDs) have been associated with atopic dermatitis (AD), including in Korean patients. Previous studies on AD have primarily focused on patients of European ancestry, while the Asian endotype exhibits distinct characteristics. This study aimed to characterize the blood proteomic signature of Korean patients with moderate-to-severe AD, with an emphasis on proteins related to CVDs. - Source: PubMed
Publication date: 2024/08/08
Jin Seon-PilKim HosuMoon Ji HwanKim-Schulze SeungheeChun Yookyung SophieNam Hyo JeongBang Yoon JiLee Ji SuKim Jung EunPark Chung-GyuKim Hyun JeLee Dong Hun - Sepsis-induced cardiomyopathy is commonplace and carries an increased risk of death. Melusin, a cardiac muscle-specific chaperone, exerts cardioprotective function under varied stressful conditions through activation of the AKT pathway. The objective of this study was to determine the role of melusin in the pathogenesis of lipopolysaccharide (LPS)-induced cardiac dysfunction and to explore its signaling pathway for the identification of putative therapeutic targets. - Source: PubMed
Publication date: 2022/03/09
Arina PietroSorge MatteoGallo AndreaDi Mauro VittoriaVitale NicolettaCappello PaolaBrazzi LucaBarandalla-Sobrados MariaCimino JamesRanieri V MarcoAltruda FiorellaSinger MervynCatalucci DanieleBrancaccio MaraFanelli Vito - High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the associations between RDW and plasma proteins implicated in the pathogenesis of CVD using a targeted proteomics panel. - Source: PubMed
Publication date: 2021/03/30
Pan JingxueBorné YanOrho-Melander MarjuNilsson JanMelander OlleEngström Gunnar