RUNDC2A Blocking Peptide
- Known as:
- RUNDC2A Blocking Peptide
- Catalog number:
- 33r-6436
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- RUNDC2A Blocking Peptide
Related genes to: RUNDC2A Blocking Peptide
- Gene:
- SNX29 NIH gene
- Name:
- sorting nexin 29
- Previous symbol:
- RUNDC2A
- Synonyms:
- FLJ12363
- Chromosome:
- 16p13.13-p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2008-03-11
- Date modifiied:
- 2018-02-13
Related products to: RUNDC2A Blocking Peptide
Related articles to: RUNDC2A Blocking Peptide
- Although pulmonary arterial hypertension (PAH) is a rare and fatal disease that is well-characterized, vasodilator-responsive PAH accounts for a minority of cases, with little mechanistic knowledge, but with dramatically improved survival. - Source: PubMed
Publication date: 2026/05/18
Karnes Jason HBao ChangleiLiang ShuxinThayer TimothyZagorski JohnNaidu Samisubbu RWest James DSchwantes-An Tae-HwiKhajouei EhsanBanerjee KasturiTiwari Hemant KFarol JuvieMartinez Kiana LLiu DingyuanNing YaoSun YananJia YangfanWang JianArora AmitBatai KenHalliday Stephen JLutz KatieWalsworth AnnaFrump Andrea LRafikova OlgaDai ZhiyuGarcia Joe G NKim Il-ManHemnes Anna RBrittain EvanBenza Raymond LNichols William CChu AiaiTang HaiyangDesai Ankit A - Growth traits are among the most important economic phenotypes targeted in the genetic improvement of beef cattle. To understand the genetic basis of growth traits in Huaxi cattle, we performed a genome-wide association study (GWAS) on body weight, eye muscle area, and back fat thickness across five developmental stages in a population of 202 Huaxi cattle. Additionally, publicly available RNA-seq data from the longissimus dorsi muscle of both young and adult cattle were analyzed to identify key genes and genetic markers associated with growth in Huaxi cattle. In total, 7.19 million high-quality variant loci (SNPs and INDELs) were identified across all samples. In the GWAS, the three multilocus models (FarmCPU, MLMM, and BLINK) outperformed the conventional single-locus models (CMLM, GLM, and MLM). Consequently, GWAS analysis was conducted using multilocus models, which identified 99 variant loci significantly associated with growth traits and annotated a total of 83 candidate genes (CDGs). Additionally, 23 of the 83 CDGs overlapped with significantly differentially expressed genes identified from public RNA-seq datasets of longissimus dorsi muscle between young and adult cattle. Furthermore, gene functional enrichment (KEGG and GO) analyses revealed that over 30% of the pathways and GO terms were associated with muscle development and fat deposition, crucial factors for beef production. Specifically, key genes identified included , , and , which are implicated in lipid metabolism, adipogenesis, and muscle growth. In summary, this study provides new insights into the genetic mechanisms underlying growth traits in Huaxi cattle and presents promising markers for future breeding improvements. - Source: PubMed
Publication date: 2025/02/02
Liu Cheng-LiRen TaoRuan Peng-ChengHuang Yong-FuCeccobelli SimoneHuang De-JunZhang Lu-PeiE Guang-Xin - is a potential functional gene associated with meat production traits. Previous studies have shown that copy number variation (CNV) could be implicated with phenotype in goats. However, in Diannan small-ear (DSE) pigs, the genetic impact of CNV on growth traits remains unclear. Therefore, this study investigated the associations between CNVs (CNV10810 and CNV10811) and growth traits in 415 DSE pigs. The results revealed that the CNV10810 mutation was significantly associated with backfat thickness in DSE pigs at 12 and 15 months old ( < 0.05), while the CNV10811 mutation had significant effects on various growth traits at 6 and 12 months old, particularly for body weight, body height, back height and backfat thickness ( < 0.05 or < 0.001). In conclusion, our results confirm that CNV plays a role in regulating growth and development in pigs, thus suggesting its potential application for pig breeding programmes. - Source: PubMed
Publication date: 2024/02/05
Yang LongLin XiaodingChen YuhanPeng PeiyaLan QunZhao HengWei HongjiangYin YulongLiu Mei - As a member of the SNX family, the () is initially identified as a myogenesis gene. Therefore, this study aimed to examine the polymorphism in the gene and its association with growth traits. In this study, we used an online platform to predict the structures of the protein and used quantitative real-time PCR to detect potential copy number variation (CNV) in Shaanbei white cashmere (SBWC) goats ( = 541), Guizhou black (GB) goats ( = 48), and Nubian (NB) goats ( = 39). The results showed that goat protein belonged to non-secretory protein. Then, five CNVs were detected, and their association with growth traits was analyzed. In SBWC goats, CNV1, CNV3, CNV4, and CNV5 were associated with chest width and body length ( < 0.05). Among them, the CNV1 individuals with gain and loss genotypes were superior to those individuals with a median genotype, but CNV4 and CNV5 of individuals with the median genotype were superior to those with the loss and gain genotypes. In addition, individuals with the gain genotype had superior growth traits in CNV3. In brief, this study suggests that the CNV of can be used as a molecular marker in goat breeding. - Source: PubMed
Publication date: 2023/08/29
Wang QianSong XiaoyueBi YiZhu HaijingWu XianfengGuo ZhengangLiu MeiPan Chuanying - There is growing evidence that the SNX family is critical for clinical prognosis, immune infiltration and drug sensitivity in many types of tumors. The relationships between the SNX29 gene and clinical prognosis as well as pan-cancer cell infiltration and drug sensitivity have not been fully elucidated. - Source: PubMed
Publication date: 2023/02/24
Xu ChengfeiLi FanghanLiu ZilinYan ChuanjingXiao Jiangwei