Ask about this productRelated genes to: TRIP6 Blocking Peptide
- Gene:
- TRIP6 NIH gene
- Name:
- thyroid hormone receptor interactor 6
- Previous symbol:
- -
- Synonyms:
- ZRP-1, OIP1, MGC10556, MGC10558, MGC29959, MGC3837, MGC4423
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-16
- Date modifiied:
- 2016-10-05
Related products to: TRIP6 Blocking Peptide
Related articles to: TRIP6 Blocking Peptide
- TFEB (transcription factor EB) regulates the expression of autophagy and lysosomal genes, is activated by various cellular stresses, and plays a key role in maintaining cellular homeostasis. Recent work demonstrates that TFEB is activated during lysosomal damage through two distinct mechanisms: ATG conjugation-dependent and -independent. TFEB activation proceeds sequentially through two modes. In the early ATG conjugation-independent mode (Mode I), APEX1 interacts with TFEB in the nucleus, maintaining its transcriptional activity and protein stability. In the later ATG conjugation-dependent mode (Mode II), CCT7 and TRIP6 translocate to lysosomes and interact with TFEB, modulating its phosphorylation and nuclear localization. Moreover, TFEB regulation induced by other cellular stresses-such as oxidative stress, proteasome inhibition, mitochondrial damage, and DNA damage-also involves either Mode I or Mode II. Our findings provide new insights into a unified understanding of TFEB regulation under diverse cellular stress conditions. - Source: PubMed
Publication date: 2026/03/30
Shima TakayukiNakamura Shuhei - Smoking is a preventable cause of colorectal cancer (CRC), and nicotine metabolism may promote tumorigenesis. We aimed to investigate the prognostic significance of nicotine metabolism‑related genes (NRGs) in colon adenocarcinoma (COAD) and to develop a gene signature for patient stratification. - Source: PubMed
Publication date: 2026/02/11
Li JunliangZhang JunyiWang DanningShen JieyiShen ChongZeng WeiqiWang Jianwei - Pancreatic cancer (PC) is a leading cause of cancer-related mortality due to late diagnosis and limited treatments. Disulfidptosis, a novel form of regulated cell death, is implicated in disease pathogenesis. This study explores disulfidptosis-related gene (DRG) signatures to identify prognostic biomarkers and immune infiltration patterns in PC using bioinformatics and single-cell analyses. - Source: PubMed
Publication date: 2026/01/27
Pei YueCheng MeijiaYu TongMa WenjingSun XiaohanZhang JingyanLi JiajiaLi WenkaiZhou YutongHu HewenQi YingchaoLiu YunenWang Yichen - The clinical heterogeneity of colon adenocarcinoma (COAD) complicates patient prognosis and treatment. While metabolic reprogramming is a key driver of tumor progression, the role of histidine metabolism in the COAD immune microenvironment remains unclear. - Source: PubMed
Publication date: 2025/12/08
Zhong HuaJin JiangdongZhang YiChen NuoLiu AnyaJiang ChenfeiZhang WenbingHe Zirui - Diabetic kidney disease (DKD), with its complex pathogenesis, is the most important cause of end-stage renal disease and has become an urgent public health problem worldwide. Heterogeneous nuclear ribonucleoprotein F () is a member of a subfamily of widely expressed nuclear heterogeneous ribonucleoproteins with biological roles in regulating gene expression and variable splicing. Some studies have investigated in DKD. However, its potential mechanism in renal intrinsic cells has rarely been reported. Therefore, it is necessary to further investigate its potential mechanism in DKD in the search for novel ideas for new therapeutic targets for DKD. - Source: PubMed
Publication date: 2025/09/09
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