LYK5 Blocking Peptide
- Known as:
- LYK5 Blocking Peptide
- Catalog number:
- 33r-6420
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- LYK5 Blocking Peptide
Related genes to: LYK5 Blocking Peptide
- Gene:
- STRADA NIH gene
- Name:
- STE20 related adaptor alpha
- Previous symbol:
- -
- Synonyms:
- NY-BR-96, LYK5, Stlk, STRAD
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-15
- Date modifiied:
- 2018-11-09
Related products to: LYK5 Blocking Peptide
Related articles to: LYK5 Blocking Peptide
- Venom immunotherapy (VIT) is a crucial therapy in Hymenoptera Venom Allergy (HVA), but limited data exist on VIT during pregnancy. However, untreated HVA poses a dangerous risk of severe anaphylaxis for both the pregnant woman and her foetus. This study aimed to evaluate the safety and efficacy of maintenance VIT during pregnancy, focusing on spontaneous abortion, preterm birth and adverse events (AEs), compared with rates expected in the general population. - Source: PubMed
Publication date: 2026/05/19
Martini MatteoSfriso GiovannaPravettoni ValerioMauro MarinaPreziosi DonatellaVettorato FrancescaLucchini GiuseppePagani MauroBadiu IulianaDolcher Maria PiaGaeta FrancescoGalati PietroMeucci ElisaPastorello ElidePatella VincenzoPucci StefanoRoncallo ChiaraSavi EleonoraSimioni LivioBilò Maria BeatriceBonadonna Patrizia - Self-healing hydrogels (SHHs) are promising materials in tissue engineering due to their ability to mimic the biomechanical properties of biological tissues and autonomously repair damage and can serve as ideal three-dimensional scaffolds for cell proliferation and differentiation. However, conventional processing methods, such as extrusion-based printing, often limit the complexity and resolution of the fabricated structures. VAT photopolymerization, particularly digital light processing (DLP), on the other hand, offers advantages in terms of resolution, printing speed, and design freedom, making it an attractive approach for developing SHHs. This study aims to develop a biocompatible and self-healing hydrogel through DLP, enhancing the structural complexity while maintaining self-repairing properties. The hydrogel is made from polyethylene glycol diacrylate (PEGDA), hydroxyethyl methacrylate (HEMA), dithiothreitol (DTT), and borax, and the solvent is PBS. Cross-linking occurs by radical photopolymerization, in which PEGDA and HEMA serve as cross-linkable monomers, while DTT and borax form borate-ester bonds, imparting self-repairing properties. Complex 3D structures were fabricated by using a commercial DLP printer, and self-healing properties were assessed. Chemical (FTIR, NMR), rheological, and mechanical analyses were performed along with cytocompatibility tests. The hydrogel exhibited successful 3D printability, allowing the fabrication of complex structures. Self-healing tests demonstrated that, after 72 h, the samples could self-repair and withstand tensile forces, maintaining their integrity after multiple damage-repair cycles. Chemical and mechanical characterization confirmed the stability and viscoelastic behavior of the material, while preliminary cytocompatibility assays indicated the suitability for tissue engineering applications. DLP-based printing enables the fabrication of self-healing hydrogels with improved resolution and design freedom. The developed hydrogel exhibits promising mechanical properties and biocompatibility, making it a strong candidate for tissue engineering applications. - Source: PubMed
Publication date: 2026/02/13
D'Aloia MariaBaruffaldi DésiréeDirè SandraCallone EmanuelaAngelini AngeloPirri Candido FabrizioRoppolo IgnazioFrascella Francesca - Accurate reference intervals for serum biochemical parameters are essential for clinical interpretation in neonatal calves, yet data for the first days of life remain limited and rarely stratified by narrow age ranges. This study established age-specific reference intervals for clinically healthy Italian Holstein-Friesian calves during the first 10 days of life and evaluated differences among three age groups (24-48 h, 3-4 days, 5-10 days). A total of 178 calves were enrolled. Serum samples were analyzed for indicators of liver function, muscle metabolism, energy metabolism, lipid profile, protein status, acute-phase response, and mineral balance. Nonparametric reference intervals were calculated for each age group. Most analytes were significantly influenced by age, except haptoglobin, total protein, and beta-hydroxybutyrate. Results highlight the dynamic physiology of the neonatal period and provide robust, age-stratified RIs to improve clinical decision-making and research interpretation in neonatal bovine medicine. - Source: PubMed
Publication date: 2026/05/13
Lorenzi ValentinaValli GiuliaTempini MicheleFusi FrancescaVitali RobertaCampana LauraSangalli ElenaVecchio DomenicoBergagna StefaniaBarberio AntonioBertocchi LuigiArchetti Ivonne - Type 2 diabetes mellitus (T2DM) and prediabetes are common complications of severe obesity. Although the Finnish Diabetes Risk Score (FINDRISC) is a widely used tool for diabetes risk assessment, its performance has not been specifically evaluated in populations with severe obesity. - Source: PubMed
Publication date: 2026/05/13
Mai SMinari SSoranna DPrina EMaestrini SRondinelli EMele CZambon AMarzullo PPattaroni LScacchi MSola Daniele - Due to their high persistence and adverse health effects in humans the use of a number of per- and polyfluoroalkyl substances (PFAS) has been restricted. As a consequence, novel PFAS are increasingly being introduced for industrial applications, although toxicological data are still limited or lacking for many of these compounds. This study examined the molecular mechanisms of action of novel PFAS with a focus on mono- and polyether PFAS with linear or branched structures and either carboxylic acid or sulfonic acid functional groups. Differentiated HepaRG cells, a model of human hepatocytes, were exposed for 24 h to different PFAS congeners at three non-cytotoxic concentrations each. Total RNA was isolated and subjected to whole transcriptome analysis. The study provides transcriptomic data for in total 33 PFAS congeners, for 13 of them for the first time. For most PFAS, the number of differentially expressed genes (DEG) increased in a concentration-dependent manner, whereas five PFAS induced only minor transcriptional changes even at the highest test concentration. Ingenuity Pathway Analysis (IPA) revealed broadly comparable transcriptional responses across all 33 PFAS, indicating convergent molecular effects in HepaRG cells despite marked structural differences among the PFAS congeners. The tested PFAS consistently activated canonical pathways related to fatty acid and lipid metabolism, mainly regulated by the nuclear receptor PPARα, and also affected pathways related to xenobiotic metabolism, partially linked to PXR and CAR signaling. In addition, several PFAS inhibited cholesterol and bile acid biosynthesis pathways. IPA further predicted effects on hepatocyte-relevant upstream regulators such as HNF4A, HNF1A, and FOXA2. Finally, IPA tox-function analysis indicated associations between PFAS-induced transcriptional changes and liver diseases related to cholestasis. - Source: PubMed
Publication date: 2026/05/13
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