Ask about this productRelated genes to: IFI35 Blocking Peptide
- Gene:
- IFI35 NIH gene
- Name:
- interferon induced protein 35
- Previous symbol:
- -
- Synonyms:
- IFP35
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-12
- Date modifiied:
- 2016-10-05
Related products to: IFI35 Blocking Peptide
Related articles to: IFI35 Blocking Peptide
- Interferon-induced protein 35 (IFI35) is a critical regulator of virus-induced immune-inflammatory responses; however, its systematic role in cancer, particularly in breast cancer (BRCA), remains unclear. This study aimed to elucidate the pan-cancer expression profile and prognostic value of IFI35 and to elucidate its functional and clinical significance in BRCA. - Source: PubMed
Publication date: 2026/08/14
Mu YudongZhang TaoHe LinLi JuanLiu Peijun - Renqing Changjue (RQCJ) is a form of Tibetan medicine recognized for its immunomodulatory effects. However, the underlying mechanisms through which it exerts these effects remain to be elucidated. - Source: PubMed
Publication date: 2026/05/21
Jiang ZhaoKong XiumeiZhang XiaoyingLv YaxinWu SiqiJi XuZhao Qin - H5N6 highly pathogenic avian influenza virus (HPAIV) poses a serious threat to both poultry and public health due to its ability to cross species barriers. Although interferon-stimulated genes (ISGs) are key components of the host's antiviral defense, a systematic identification and functional characterization of duck ISGs has not yet been conducted. In this study, we identified 815 potential duck ISGs induced by type II interferon (IFN-γ) in duck embryo fibroblasts (DEFs). The majority of these type II ISGs were enriched in immune-related pathways, including "cytokine-cytokine receptor interaction" and "influenza A". Functional validation using siRNA-mediated knockdown demonstrated that six ISGs, including duIFI35, promote H5N6 AIV replication when silenced. Through TUNEL assay, flow cytometry, and apoptotic pathway analysis, Our analysis revealed that H5N6 AIV infection markedly upregulates apoptotic genes such as Fas, FADD, caspase-8, BAK, cytochrome c, APAF1, caspase-9, and caspase-3 (P < 0.05), thereby promoting apoptosis in DEFs. In investigating the antiviral mechanism of duIFI35, it was found that overexpression of duIFI35 further enhanced H5N6-induced apoptosis, as evidenced by increased transcription of these apoptotic genes, whereas duIFI35 knockdown had the opposite effect. Importantly, the antiviral effect of duIFI35 was significantly diminished upon treatment with the caspase inhibitor Z-VAD-FMK (20 μM) (P < 0.05), indicating that its antiviral activity is mediated through apoptosis induction. Collectively, this study provides the first systematic identification of type II ISGs in ducks and reveals duIFI35-mediated apoptosis as a critical antiviral mechanism, offering foundational insights into ISG-driven innate immunity against AIV in waterfowl. - Source: PubMed
Publication date: 2026/04/16
Zhang TaoYang NaMa LuluXu FengxiangLin XiaobingHuang JiangwuGao FeiLiao MingFeng MinDai Manman - Lupus nephritis (LN) represents the most severe renal manifestation of systemic lupus erythematosus (SLE), contributing to significant morbidity. While current assessments focus on glomerular pathology, tubulointerstitial lesions may offer critical insights into disease progression and treatment response. This study develops a clinical prediction model integrating tubulointerstitial molecular signatures. We performed bioinformatics analysis using two independent tubulointerstitial gene expression datasets (GSE113342 and GSE200306), applying batch effect correction and principal component analysis (PCA) to identify differentially expressed genes (DEGs). A protein‒protein interaction (PPI) network isolated hub genes, and least absolute shrinkage and selection operator (LASSO) regression defined the novel "Nscore" parameter predictive of treatment response. The Nscore, incorporating seven key genes (EGR1, IL6R, TFRC, CCL19, IFI16, IFI35, and Fra1), showed a significant positive correlation with 24-h proteinuria and effectively distinguished complete-response (CR)/partial-response (PR) from non-response (NR). Immune deconvolution using the CIBERSORT algorithm revealed an increased abundance of T follicular helper (Tfh) cells and M1 macrophages in NR samples. A clinical nomogram integrating Nscore and sex demonstrated excellent discrimination. This model combines molecular biomarkers with clinical parameters to improve personalized therapeutic stratification, advancing treatment strategies beyond traditional glomerulocentric paradigms and identifying immune cell signatures as potential targets for immunomodulatory interventions. - Source: PubMed
Publication date: 2026/04/02
Ke JialongGu GuanghongNi WenpengHe JialinZeng ZhouyuLin RunpeiPeng JianmingDeng KunyiWen LijuanChen YanhuiTan NanZhang Chilun - Hepatitis B virus (HBV) infection is a major health problem with hundreds of millions of people still chronically infected worldwide. Although it is known that cytokines can inhibit HBV replication in infected hepatocytes, much is still unknown about the underlying mechanisms or mediators. - Source: PubMed
Publication date: 2026/03/30
Kim NayeonShin Jae JinOh Jae WonWon JuheeLee Ah RamDezhbord MehrangizPark JeongwooLee Ki-YoungKim Dong-SikKim Kwang PyoKim Kyun-Hwan