Ask about this productRelated genes to: FZD2 Blocking Peptide
- Gene:
- FZD2 NIH gene
- Name:
- frizzled class receptor 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-18
- Date modifiied:
- 2015-09-11
Related products to: FZD2 Blocking Peptide
Related articles to: FZD2 Blocking Peptide
- Myxofibrosarcoma (MFS) is a rare soft-tissue sarcoma with limited systemic therapy options, necessitating preclinical platforms that better simulate clinical drug responses. We investigated how 2D monolayers versus 3D spheroids shape the baseline transcriptome and doxorubicin (DOX)-responsive programs across six patient-derived MFS cell lines. RNA sequencing revealed that 3D culture induces a distinct transcriptomic state characterized by the enrichment of microenvironment-associated stress programs, such as hypoxia, inflammatory/NF-κB signaling, and glycolysis, alongside the suppression of proliferation-related pathways. Although the global DOX-induced transcriptional response was highly environment-dependent, we identified a robust core of six regulators-MCRIP1, FGF12, HGF, EMSY, FZD2, and SECISBP2-whose transcriptional changes consistently correlated with cell survival rates across both 2D and 3D geometries. These genes are involved in transcriptional plasticity, redox homeostasis, and bypass survival signaling, providing a mechanistic basis for DOX resistance that transcends culture conditions. Our findings demonstrate that while culture geometry is a critical determinant of the MFS transcriptome, a robust set of environment-agnostic regulators dictates DOX efficacy. Integrating 3D systems with these specific transcriptomic readouts enhances the interpretability of drug screenings and supports the prioritization of rational therapeutic combinations for this rare sarcoma. - Source: PubMed
Publication date: 2026/04/21
Yoshimatsu YukiShiota YomogiKondo Tadashi - Bronchiectasis (BE), Chronic Obstructive Pulmonary Disease (COPD) and Primary Immunodeficiency (PID) are distinct respiratory conditions that share features such as chronic inflammation, airway obstruction, and recurrent infections. Despite distinct underlying causes, disease manifestations often overlap clinically, complicating diagnosis and treatment. We aimed to characterise shared and disease-specific immune mechanisms in BE, COPD, and PID using a multi-omics approach across blood and sputum. - Source: PubMed
Publication date: 2026/02/25
Graeter StefanieGonzalez-Jaramillo NathaliaWildschut Mattheus H ECapriotti LuigiSaxenhofer MoritzRobador Jose RamonMonaghan KatherineWoodman NaomiField JudithWilson NickRees MeganHauswald MariaRoca Carlos PFeussner AnnetteSchulze IlkaStewart AlastairSchaub AlexanderChan SamanthaDouglass Jo ASchnell Anna - Accumulating evidence has revealed that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor progression and the immune microenvironment, which further results in a high rate of recurrence and metastasis. The EMT immune signaling pathway provides a great perspective for designing personalized therapies. - Source: PubMed
Publication date: 2026/01/19
Liang WeiWang Zi-YingShao Quan-FengLi Yuan-YuanZhu BeiQin Xi-HuChen Wei-Xian - Histamine signalling is critical in heart failure (HF). Histamine N-methyltransferase (HNMT) serves as the primary enzyme responsible for histamine clearance in heart, but its role in HF remains undefined. This study investigates HNMT-mediated metabolic-epigenetic crosstalk in HF and evaluates therapeutic strategies targeting this axis. - Source: PubMed
Publication date: 2026/01/22
Zhang JinyanJiang HaoLiu LiweiLi XinHong WenxuanXu LeiDong ZhenXu ZhuocongGao JinfengSun XiaoleiLuo WeiLiu JinSong YuWang PengZhang JinghongCui YikaiHuang LuZhou XianhaoZhang YinHu KaiYang JingGe JunboSun Aijun - is a commercially valuable freshwater fish in the Pearl River Basin, renowned as the "King of Freshwater Fish." Due to habitat degradation and overfishing, its wild population has declined sharply, leading to its listing as a National Key Protected Wild Animal of Class II in China. Artificial breeding is therefore crucial for conservation, yet progress is hindered by the lack of clear sexual dimorphism and poor understanding of its sex differentiation mechanism. In this study, we performed high-throughput RNA sequencing (RNA-seq) to compare gonadal transcriptomes of male and female . A total of 3245 differentially expressed genes (DEGs) were identified, including 3122 male-biased and 123 female-biased DEGs, which clustered into three distinct expression patterns. Enrichment analysis revealed that genes associated with the TGF-β (Transforming Growth Factor-beta) and GnRH (Gonadotropin-Releasing Hormone) signaling pathways were significantly enriched in the female gonads, suggesting their potential roles in gonadal differentiation. From the DEG set, we further highlighted five genes with pronounced sex-biased expression: (RNA Binding Motif Protein 46) exhibited gonad-specific expression, whereas (v-myc avian myelocytomatosis viral oncogene homolog), (Angiopoietin-Like 4), (SRY-Related HMG-Box Gene 9), and (Frizzled Class Receptor 2) showed marked expression differences between male and female gonads. These findings provide insights into the molecular mechanisms underlying sex differentiation in , offer potential molecular markers for sex identification, and establish a scientific basis for germplasm conservation and the optimization of breeding techniques. - Source: PubMed
Publication date: 2025/12/09
Luo WenyinHuang ShaojunLi GuanglveHu DanChen JiemeiLi HuiqinYu HeminChen YanyunZhu JiajieHu Qiaomu