LOC400451 Blocking Peptide
- Known as:
- LOC400451 Blocking Peptide
- Catalog number:
- 33r-6356
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- LOC400451 Blocking Peptide
Related genes to: LOC400451 Blocking Peptide
- Gene:
- FAM174B NIH gene
- Name:
- family with sequence similarity 174 member B
- Previous symbol:
- -
- Synonyms:
- LOC400451, MGC102891
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-06-19
- Date modifiied:
- 2019-04-08
Related products to: LOC400451 Blocking Peptide
Related articles to: LOC400451 Blocking Peptide
- : While the immunomodulatory function of FAM174B in bladder cancer (BLCA) has yet to be fully elucidated, elucidating its biological mechanisms could potentially enhance immunotherapeutic outcomes for this malignancy. : Bulk RNA-seq data from TCGA and GEO databases were analyzed to investigate FAM174B expression patterns and immune landscape characteristics in pan-cancer. The immunoregulatory role of FAM174B in BLCA was systematically evaluated through immune infiltration analysis, immunomodulator profiling, cancer-immunity cycle assessment, and immune checkpoint examination. Validation was performed using the IMvigor210 immunotherapy cohort and a combined GEO dataset (n=871). A machine learning-based immune-related signature was developed for prognostic and therapeutic response prediction. : FAM174B was highly expressed in cancer tissues across multiple human cancer types including BLCA. Specifically, FAM174B negatively correlated with various immunological features including immunoregulators and immune cell infiltration abundances, suggesting that FAM174B remodeled the microenvironment to a non-inflamed phenotype of BLCA. Besides, patients with high-FAM174B expression may process limited sensitivity to immunotherapy and increased likelihood of hyperprogression. Consensus molecular classification analysis indicated that elevated FAM174B is related to a luminal BLCA subtype which was characterized by reduced immune infiltration, inhibited immuno- and chemo-therapeutic responses, yet increased response to angiogenesis inhibitors and targeted therapy. Furthermore, the immune-related signature, formulated through a machine learning-integrated approach, is shown to be a dependable indicator for predicting cancer prognosis and the efficacy of immunotherapy responses for BLCA. : Given the pivotal role of FAM174B in shaping the non-inflamed tumor microenvironment of BLCA, therapeutic targeting of FAM174B may represent a promising strategy for BLCA management. Furthermore, FAM174B expression could serve as a potential biomarker for predicting molecular subtypes and treatment responsiveness in BLCA patients. - Source: PubMed
Publication date: 2025/08/11
Chen HualinMa LinJi ZhigangDong Jie - Mucinous adenocarcinoma (MAC) is a peculiar histological subtype of colorectal cancer (CRC) with distinct medical, disease-related, and genetic characteristics. The prognosis of MAC is generally poorer less favorable compared to non-specific adenocarcinoma (AC), but the prognostic indicator of MAC is rare. Therefore, this study aims to identify potential biomarkers and construct a prognostic model to better predict patient outcomes in MAC. - Source: PubMed
Publication date: 2024/10/29
Tan XiangwenFang QingXu YunhuaLi ShuxiangYuan JinyiXu KunmingChen XiguangFu GuangLiu YaruiHuang QiulinPeng XiudaXiao Shuai - The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical development. Using genomic information from different sources, we evaluated the immune microenvironment and genomic profile of prostate tumors with high expression of KLK2. KLK2 was specifically expressed in PRAD but it was not significant associated with Gleason score. Additionally, KLK2 expression did not associate with the presence of any immune cell population and T cell activating markers. A mild correlation between the high expression of KLK2 and the deletion of TMPRSS2 was identified. KLK2 expression associated with high levels of surface proteins linked with a detrimental response to immune checkpoint inhibitors (ICIs) including CHRNA2, FAM174B, OR51E2, TSPAN1, PTPRN2, and the non-surface protein TRPM4. However, no association of these genes with an outcome in PRAD was observed. Finally, the expression of these genes in PRAD did not associate with an outcome in PRAD and any immune populations. We describe the immunologic microenvironment on PRAD tumors with a high expression of KLK2, including a gene signature linked with an inert immune microenvironment, that predicts the response to ICIs in other tumor types. Strategies targeting KLK2 with T cell engagers or antibody-drug conjugates will define whether T cell mobilization or antigen release and stimulation of immune cell death are sufficient effects to induce clinical activity. - Source: PubMed
Publication date: 2024/02/13
Paniagua-Herranz LucíaMoreno IreneNieto-Jiménez CristinaGarcia-Lorenzo EstherDíaz-Tejeiro CristinaSanvicente AdriánDoger BernardPedregal ManuelRamón JorgeBartolomé JorgeManzano AranchaGyorffy BalázsGutierrez-Uzquiza ÁlvaroPérez Segura PedroCalvo EmilianoMoreno VíctorOcana Alberto - Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterogeneity is established during the development of the vascular system, especially arteriovenous specification of ECs, remains incompletely characterized. - Source: PubMed
Publication date: 2024/02/13
Chen JianZhang XiaoranDeLaughter Daniel MTrembley Michael ASaifee ShailaXiao FengChen JiehuiZhou PingzhuSeidman Christine ESeidman Jonathan GPu William T - Largemouth bass (Micropterus salmoides) has significant economic value as a high-yielding fish species in China's freshwater aquaculture industry. Determining the major genes related to growth traits and identifying molecular markers associated with these traits serve as the foundation for breeding strategies involving gene pyramiding. In this study, we screened restriction-site associated DNA sequencing (RAD-seq) data to identify single nucleotide polymorphism (SNP) loci potentially associated with extreme growth differences between fast-growth and slow-growth groups in the F generation of a largemouth bass population. - Source: PubMed
Publication date: 2024/01/16
Hua JixiangZhong ChunyiChen WenhuaFu JianjunWang JianWang QingchunZhu GeyanLi YanTao YifanZhang MaoyouDong YalunLu SiqiLiu WentingQiang Jun