Ask about this productRelated genes to: RPS21 Blocking Peptide
- Gene:
- RPS21 NIH gene
- Name:
- ribosomal protein S21
- Previous symbol:
- -
- Synonyms:
- S21
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1993-09-29
- Date modifiied:
- 2016-10-05
Related products to: RPS21 Blocking Peptide
Related articles to: RPS21 Blocking Peptide
- Colorectal cancer (CRC) remains a leading cause of cancer mortality, yet no systematic effort has linked druggable CRC driver genes to downstream ion channel effectors. We integrated differential expression analysis, weighted gene co-expression network analysis (WGCNA), and protein-protein interaction (PPI) network pharmacology to identify CRC hub genes and their ion channel connections, validated by dual single-cell perturbation approaches: variational graph autoencoder-based virtual knockout (VGAE-KO) and experimental HCT116 CRISPRi Perturb-seq (6 genes, 8445 cells). WGCNA identified 100 hub genes spanning three functional programs. Ribosomal proteins link to K channels ( → , targetable by EMA-approved ataluren, passed dual validation at 97.8th-98.7th percentile). RNA processing genes connect to Cl channels ( → , strongest signal at 99.8th-99.4th percentile). Immune checkpoint receptors (, ) connect via PPI intermediates to Ca2+ and K channels, targetable by relatlimab (FDA-approved) and varlilumab (Phase 2). This work maps previously unknown links between CRC driver genes and ion channel regulation, with the ataluren-- axis ready for pharmacological testing. - Source: PubMed
Publication date: 2026/04/10
Dong ZhongyuanMeng XuanlinWang Lianghua - Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes mellitus (DM), likely involves mitophagy in its progression. However, the exact mechanisms remain poorly understood. - Source: PubMed
Publication date: 2026/01/12
Zhang YifanNiu LiangjieXia HuikaWang Jianmin - Leprosy is a debilitating disease that requires early detection for effective control, yet diagnosis still relies on clinical signs. Previous RNA-Seq analysis of coding genes from leprosy patients' household contacts (HHC) who developed leprosy (progressors) and those who did not, revealed a 4-gene RNA signature, RISK4LEP, that predicted leprosy 4-61 months before clinical onset (AUC: 0.86). To improve this signature, the present study included non-coding genes and applied novel Differential Gene Expression (DGE) analyses and machine learning approaches to the RNA-Seq dataset. This strategy identified significant DGE between progressors and HHC for 40 genes. Next, the 10 most significantly different expressed genes, as well as genes from the optimal 3-gene signatures, were validated by RT-qPCR in an independent cohort. This analysis confirmed the diagnostic potential to discriminate progressors from HHC for 12 genes. Moreover, RPS21 and SNHG5 genes were each significantly higher expressed in progressors compared to diagnosed leprosy patients, suggesting their temporary role during early (preclinical) leprosy. Furthermore, the optimal 3-gene signature consisted of two non-coding genes and one coding gene (SNHG5, SNHG8, C6orf48; sensitivity: 88%; specificity: 88%; AUC: 0.96). This study thus identified an improved prospective host transcriptional risk signature in blood based on non-coding genes predicting the development of leprosy. - Source: PubMed
Publication date: 2025/12/27
Almeida Matheus RogerioGherardi Elisavan Veen SuzanneMaharavo LucaRosmolen Aartvan Eerde EmmaVerbeek Fons JKhatun MarufaSoren SantoshChowdhury Abu SufianAlam KhorshedRoy Johan Chandrade Macedo Cristiana Santosvan Hooij AnoukGeluk Annemieke - Acute lymphoblastic leukemia (ALL) is the most prevalent malignant tumor in children, with B-cell ALL (B-ALL) accounting for 85% of cases. Despite advancements in chemotherapy and supportive care, a subset of high-risk B-ALL patients still experience relapse post-treatment. The molecular mechanisms underlying the relapses after intensified chemotherapy remain poorly understood. - Source: PubMed
Publication date: 2025/11/12
Liu LiMao XiaoyanYang ChunhuiLi NaZhou YanZhang LiJiang NanjingHuang YuYin ShigangXie HuangfanTian Xin - COVID-19, including its post-acute sequelae (Long COVID), is increasingly recognized as involving persistent immune dysregulation and chronic inflammation. Severe and prolonged disease states are often accompanied by sustained cytokine release, immune cell exhaustion, and ongoing cell-cell communication that shapes the inflammatory milieu. Among immune subsets, CD8 T cells play a central role in antiviral defense, yet the molecular mechanisms linking their dysfunction to prolonged inflammation remain incompletely understood. - Source: PubMed
Publication date: 2025/10/22
Liu HengruiXu ZewenKarsidag IlaydaWang PanpanWeng Jieling