Ask about this productRelated genes to: Clec1b Blocking Peptide
- Gene:
- CLEC1B NIH gene
- Name:
- C-type lectin domain family 1 member B
- Previous symbol:
- -
- Synonyms:
- CLEC2
- Chromosome:
- 12p13.31-p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-09
- Date modifiied:
- 2018-02-13
Related products to: Clec1b Blocking Peptide
Related articles to: Clec1b Blocking Peptide
- Megakaryopoiesis is an elaborate biological process that primarily occurs in the bone marrow. To gain deeper insights into molecular mechanisms driving normal megakaryopoiesis, we utilized an in vitro human megakaryocytic culture system based on mobilized peripheral blood-derived CD34 cells. Following fluorescence-activated cell sorting (FACS) isolation of CD41 and CD41 megakaryocyte (MK) subsets, mature MKs were confirmed through characterization of MK-specific surface markers, ploidy analysis, Giemsa staining, and immunofluorescence. Subsequent bulk RNA sequencing of these distinct populations enabled the identification of differentially expressed genes (DEGs) and enriched pathways. Based on our CD34-derived MK differentiation model, the expression of CD41 was found robustly induced by day 4 and further elevated by day 10. The CD41 population exhibited marked co-expression of CD42b and CD61, a significantly higher proportion of polyploid cells (≥16 N), along with characteristic morphological features of mature MKs, including proplatelet formation, cytoplasmic maturation, and cell size enlargement compared to the CD41 subset. Transcriptomic profiling of these two populations identified 1877 up-regulated and 1817 down-regulated DEGs in CD41 MKs. Protein-protein interaction (PPI) network analysis of the key DEGs revealed hub genes including VWF, PF4V1, SELP, PF4, GP1BA, CD40LG, PPBP, CLEC1B, P2RY12, and THBS1. Functional enrichment underscored the acquisition of migratory, adhesive, and secretory capacities, marked by significant upregulation of platelet activation and wound healing signatures. Pathway analysis further indicated coordinated activation of focal adhesion, cytoskeletal reorganization, glycerolipid metabolism, and neuroactive ligand-receptor interaction during maturation. This study provides an integrative transcriptomic blueprint of human MK maturation and highlights the novel candidate targets for thrombopoiesis. - Source: PubMed
Publication date: 2026/05/15
Zhang ZiyanWang YueLiu Peng - The high global mortality of hepatocellular carcinoma (HCC) underscores the need for reliable non-invasive diagnostic biomarkers. In this study, transcriptomic analyses were performed on peripheral blood mononuclear cell (PBMC) and tumor datasets from HCC patients to identify differentially expressed genes (DEGs) using an adjusted p-value 〈 0.01 and |log2FC| 〉 1. Functional enrichment analyses revealed predominant immune-related pathways in PBMCs and metabolic pathway dysregulation in tumor tissues. Integration of PBMC and tumor profiles identified STEAP4, EPC1, CLEC1B, and LCN2 as shared DEGs. Survival analyses indicated that elevated expression of STEAP4, EPC1, and CLEC1B was associated with poorer overall survival in HCC patients. Collectively, these findings highlight consistent transcriptional alterations in PBMCs and tumor tissues and suggest that STEAP4, EPC1, and CLEC1B may serve as potential non-invasive biomarkers with diagnostic and prognostic relevance in HCC. - Source: PubMed
Publication date: 2026/02/26
Khojand SoheylaZahmatkesh NedaHassani ArezooDamerchiloo ZahraNikoo ZahraHeidarzadehpilehrood Roozbeh - To explore associations between circulating proteomic pathways and structural, functional, and symptomatic measures of small- and large-fiber neuropathy and corneal immune activation in people with Type 2 diabetes (T2D). - Source: PubMed
Publication date: 2026/03/18
Ponirakis GeorgiosAl-Janahi IbrahimElgassim EinasDalloul Rajaa S DPetropoulos Ioannis NGad HodaKhan AdnanZaghloul Hadeel BAli HamdaSiddique Mashhood AMohamed Fatima F SAhmed Lina H MDakroury YoussraEl Shewehy Abeer M MSaeid RubaMahjoub FadwaAl-Noubi Muna NSarwath HinaPaul PradiptaKaul RidhimaSalivon IuliiaZirie Mahmoud AAl-Ansari YousufAtkin Stephen LSchmidt FrankMalik Rayaz A - Neuro-related proteins are promising biomarkers and therapeutic targets for Parkinson's disease (PD), yet their specific roles remain uncertain. - Source: PubMed
Publication date: 2026/02/21
Zhou HangWang ZihaoTan ZixinDeng BinYang WanlinHuang ZifengGuo XingfangLi JintaoWang XinhaoYu YinghuaDeng ChaoZheng WenhuaZhang XuChen XiYue JianhuiYang ChengwuCui XiaoyingPoplawska-Domaszewicz KarolinaChaudhuri K RayZhou ZhidongXiao BinChan Ling-LingFoo Jia NeeTan Eng-KingWang Qing - Hepatocellular carcinoma (HCC), a prevalent liver malignancy, is closely associated with dysregulated lipid metabolism. Endocrine disrupting chemicals (EDCs) can bind to nuclear receptors (NRs) and potentially induce carcinogenesis, but their specific influence on HCC progression remains unclear. To investigate this relationship, we combined bioinformatic analyses with experimental validation in the present study. Differential expression analysis of public HCC datasets (GSE14323, GSE17548, and GSE25097) identified candidate genes, which were further refined via weighted gene co-expression network analysis (WGCNA) and machine learning algorithms (RF and SVM-RFE), pinpointing NPY1R and CLEC1B as key genes. Their downregulation in HCC was validated in an independent dataset (GSE54236) and in clinical liver tissues (n = 118). Molecular docking and dynamics simulations prioritized perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) as high-affinity binders to the proteins encoded by these genes. In vitro, exposure to PFOA/PFOS dose-dependently suppressed NPY1R and CLEC1B expression in HepG2 cells. Chromatin immunoprecipitation assays revealed that PFOA/PFOS inhibit the binding of estrogen receptors (ERα and ERβ) to the promoters of these genes, leading to reduced transcription and increased lipid accumulation. Knockdown of ERα/ERβ exacerbated, while their overexpression rescued, the lipid-metabolic disruption induced by PFOA/PFOS. These findings indicate that EDCs such as PFOA and PFOS may promote HCC progression by disrupting lipid metabolism via interference with NR-dependent gene regulation, highlighting a novel environmental-toxicological axis in hepatocarcinogenesis. - Source: PubMed
Publication date: 2026/01/21
Xu ShujingQiao ShikaiZhang ShuoLiu ChunChen LiDai BinghuaYang ChangqingXia LuXiong GuangsuZhao LuyingLi Jing