Ask about this productRelated genes to: GIPC2 Blocking Peptide
- Gene:
- GIPC2 NIH gene
- Name:
- GIPC PDZ domain containing family member 2
- Previous symbol:
- -
- Synonyms:
- FLJ20075, SEMCAP-2
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-28
- Date modifiied:
- 2015-11-18
Related products to: GIPC2 Blocking Peptide
Related articles to: GIPC2 Blocking Peptide
- Ovarian cancer (OC) ranks as the seventh most prevalent malignancy diagnosed in women. This work sought to delineate the hub and core genes, as well as the probable pathways implicated in the molecular pathogenesis of ovarian cancer (OC). - Source: PubMed
Publication date: 2026/02/04
Abroudi Ali ShakeriJalaeianbanayan AryanDjamali MelikaAzizi Hossein - Mesenchymal stem cell (MSC) differentiation is a cornerstone of regenerative medicine with a wide range of applications in tissue engineering and translational therapies. However, the molecular mechanisms underlying MSC differentiation remain incompletely understood, preventing the full leveraging of their therapeutic potential. Central to these complex molecular networks are dynamic protein-protein interactions, with scaffolding proteins serving as master coordinators. GAIP-interacting protein C-terminus 2 (GIPC2) functions as an adaptor protein involved in mediating such interactions and may influence MSC fate by regulating differentiation-related signaling pathways. In this study, we identified GIPC2 as a novel regulator of adipogenic differentiation in human umbilical cord-derived MSCs (UC-MSCs). Mechanistically, GIPC2 interacts directly with pyruvate kinase M2 (PKM2) via its PDZ domain, promoting PKM2 nuclear translocation. In the nucleus, PKM2 facilitates the activation of sterol regulatory element-binding protein 1 (SREBP1), a transcription factor essential for lipid biosynthesis and adipocyte maturation. Our findings show that GIPC2 drives MSC adipogenic differentiation by orchestrating the PKM2-SREBP1 signaling axis. This study reveals a previously unrecognized regulatory mechanism, highlighting the pivotal role of GIPC2 at the intersection of metabolic regulation and transcriptional control. These insights not only deepen our understanding of MSC differentiation but also open new avenues for enhancing MSC-based therapeutic strategies. - Source: PubMed
Publication date: 2026/01/07
Wang JiayiXin ChengqiSun ZhaokaiZhao MengkeZan YaoyaoLv ZhongyueZhu ShuaiyuLiu JingWang Liang - The Muchuan Black Bones Chickens represent a significant subtype of the Sichuan mountain black bones chickens. In the breeding of black bone chickens, the degree of melanization tends to separate due to hybridization, while molecular-assisted breeding techniques were still limited, and the key genes involved in melanin deposition in the early growth of black bones chickens have yet to be validated. Hypothesize that melanin deposition in Muchuan Black Bones Chickens was governed by specific genetic and metabolic regulators that can be systematically identified. This study aims to identify key genes and metabolites associated with melanin in Muchuan Black Bones Chickens through integrated transcriptomic and metabolomic analyses. CDP-ethanolamine, m-trigallic acid, UDP-4-dehydro-6-deoxy-D-glucose, glucoiberverin, and uridine diphosphate glucuronic acid (UDP glucuronic acid) were identified as significant differential metabolites, which were intimately linked to phenylalanine, tyrosine, and tryptophan biosynthesis associated with melanin accumulation. A total of 73 differentially expressed genes, including cAMP response element-binding protein 5 (CREB5) and GIPC PDZ domain containing family member 2 (GIPC2), were enriched in the neuroactive ligand-receptor interaction pathway, arginine-proline metabolism pathway, histidine metabolism, terpenoid backbone biosynthesis, and glycerophospholipid metabolism. This study identified significant metabolites and regulatory genes associated with melanin synthesis, establishing a theoretical foundation for the breeding and selection of chickens. - Source: PubMed
Publication date: 2025/12/30
Wei LiuHong-Wei JieMing-Chao GaoXiu-Mei YaoQiong YinHai XiangZheng MaZheng-Fen ZhangLiang LiHua LiHao QiFei Ye - Hypoxia is a hallmark of the colorectal cancer (CRC) tumor microenvironment (TME) that drives malignant progression, chemoresistance, and immune evasion. However, the cellular heterogeneity underpinning hypoxic responses in CRC and its impact on prognosis remain incompletely understood. - Source: PubMed
Publication date: 2025/08/26
Duan Xiao-CuiZhou YanFeng FanJiang Hai-BoWang Mei-LinHan ZhePang Hong-FeiLiu Yu-HangJia Heng-ZheHe Meng-Xu Hong-PanWang Yuan-Yuan - Emerging evidence indicates a potential association between aberrant expression of GIPC PDZ Domain Containing Family member 2 (GIPC2) and the progression of colorectal cancer (CRC). However, the detailed characteristics of GIPC2 expression and its prognostic implications in CRC remain to be thoroughly elucidated. - Source: PubMed
Publication date: 2025/06/17
Gu JiaoyangQi XingYu BinWang YananZhang LitingLi ShuaiXin Yu