Ask about this productRelated genes to: RPS27L Blocking Peptide
- Gene:
- RPS27L NIH gene
- Name:
- ribosomal protein S27 like
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-03
- Date modifiied:
- 2016-10-05
Related products to: RPS27L Blocking Peptide
Related articles to: RPS27L Blocking Peptide
- Venous thromboembolism (VTE) is a common vascular disease and a major cause of mortality. Development of early diagnostic biomarkers that accurately predict the occurrence of VTE is key for its initial management. The present study was designed to identify potential early diagnostic biomarkers based on the crosstalk between pyroptosis and VTE. The GSE19151 and GSE48000 datasets were utilized as the training and validation cohorts, respectively. Pyroptosis-related genes (PRGs) were sourced from the existing literature. Multiple bioinformatic analyses were conducted to pinpoint key PRGs in VTE. The possible functions of these genes were elucidated through gene set enrichment analysis (GSEA). Molecular regulatory networks were synthesized to probe into the underlying molecular mechanism of VTE. Moreover, a total of 5 pairs of frozen blood samples were analyzed quantifiably by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to evaluate the expression levels of these biomarkers. a total of Five critical biomarkers (RPL31, RPL34, RPL9, RPS27L and HINT1) were eventually screened, with significantly elevated expression levels observed in VTE samples in both the training and validation cohorts compared with control. The RT-qPCR results further confirmed that expression trends of these genes were consistent with those in the GSE19151 and GSE48000 datasets. GSEA indicated a correlation between the five biomarkers and ribosomal proteins as well as oxidative phosphorylation signaling pathways, suggesting their potential role in triggering VTE by regulating pyroptosis-inflammation-coagulation axis. A total of five critical pyroptosis-related biomarkers have been initially characterized, showing potential for early diagnosis of VTE. While these findings are promising, further investigation into the precise mechanisms and clinical thresholds is warranted. - Source: PubMed
Publication date: 2025/11/18
Han ShengbinXu JingzheYu ChenchenGuan HongxiDing Shun - Identification of cell type-specific and temporally dynamic regulatory features of schizophrenia (SCZ) risk genes is essential for advancing mechanistic neurobiological studies. This study systematically dissected the genetic architecture and neurodevelopmental mechanisms of SCZ by integrating genome-wide association study (GWAS) data from European (N = 130,644) and East Asian (N = 30,761) population, alongside multi-omics and single-cell sequencing analyses. Cross-method validation identified seven core genes (e.g., MDK, RERE, ERBB4), with RERE exhibiting a notably high eQTL-SCZ colocalization probability of 92.8-93.9%. Single-cell and epigenetic analyses reveal that the spatiotemporal dynamics of RERE may lead to differences in its mediated SCZ disease risk at the levels of genetic variation and transcriptional regulation. Cleavage Under Targets and Tagmentation (CUT&Tag) confirmed that RERE directly regulates synaptic genes such as PPP4R3B and RPS27L, and its co-expression network was found to be strongly linked to SCZ risk. This study unveils a RERE-mediated epigenetic-neurodevelopmental axis and suggests that GABAergic neurons may be a potential new target for the treatment of SCZ. Future validation using organoid models and exploration of clinical translation are warranted. - Source: PubMed
Publication date: 2025/11/26
Shen JingXiao Chenxu - RNA-binding proteins (RBPs) play a pivotal role in post-transcriptional regulation of gene expression, critically influencing skeletal myogenesis, muscle growth, and regeneration. Despite the recent identification of RBP Rps27l (ribosomal protein S27-like) as a regulator affecting myogenic proliferation and differentiation, its functions and regulatory mechanisms in skeletal muscle development remain largely unknown. In this study, it is observed that muscle-specific Rps27l knock-in (M─KI) mice exhibit significantly increased muscle mass, enlarged myofiber size, a higher proportion of fast-twitch myofibers, and enhanced muscle regeneration capabilities compared to wild-type controls. Overexpression of Rps27l promotes myoblast proliferation while inhibiting differentiation in skeletal muscle cells. Mechanistically, it is revealed that the expression of Rps27l is negatively regulated by SIX4, a myogenic transcription factor. The N-terminal intrinsically disordered region of RPS27L facilitates liquid-liquid phase separation (LLPS) and interacts with IGF1 to collaboratively regulate myogenesis. The findings uncover the novel regulatory roles of RPS27L in skeletal muscle and highlight the significance of RPS27L-driven LLPS in myogenesis. - Source: PubMed
Publication date: 2025/08/31
Liu XiaoqinYao YilongYan JunyuZeng MuFan XinhaoTang YijieLi JijuLiu YanwenYan ShanyingWang WeiChen LijuanChen RuipuHuang YuxinCalnan HonorWang HengGardner GrahamYang YalanTang Zhonglin - Obesity-related asthma (OA) is a severe asthma endotype that disproportionately affects children from minority ethnic groups. We previously identified downregulation of RPS27L (40S ribosomal protein S27-like) in CD4+ (T-helper) cells from children with OA compared to cells from healthy-weight asthma that was associated with the C allele at the rs6494395 locus. Consistent with elevated allele frequencies in populations with Latino and African ancestries, we found a higher allele frequency of rs6494395 in Hispanic/Latino and African American children with OA. - Source: PubMed
Yang DavidGriffen AnthonyIsshiki MarikoGreally John MRastogi DeepaRaj Srilakshmi M - The DNA replication stress (RS) response is crucial for maintaining cellular homeostasis and promoting physiological longevity. However, the mechanisms by which long-lived species, such as bats, regulate RS to maintain genomic stability remain unclear. Also, recent studies have uncovered noncanonical roles of ribosome-associated factors in maintaining genomic stability. In this study, somatic skin fibroblasts from the long-lived big-footed bat ( ) were examined, with results showing that bat cells exhibited enhanced RS tolerance compared to mouse cells. Comparative transcriptome analysis under RS conditions revealed pronounced species-specific transcriptional differences, including robust up-regulation of ribosome biogenesis genes in bat cells and a markedly reduced activation of the P53 signaling pathway. These features emphasize a distinct homeostatic strategy in bat cells. Nuclear fragile X mental retardation-interacting protein 1 ( ), a ribosome-associated factor highly expressed in bat fibroblasts, was identified as a potential integrator of ribosomal and P53 signaling via its association with ribosomal protein S27-like (Rps27l). These findings provide direct cellular and molecular evidence for a noncanonical RS response in bats, highlighting a deeper understanding of the biological characteristics and genomic maintenance mechanisms of long-lived species. - Source: PubMed
Huang Xiao-YanLiu Xiu-YunWang WeiLiu Gao-JingZhu You-LongWen XiaoLi Kai-QinZhao Bo