Ask about this productRelated genes to: OSBPL3 Blocking Peptide
- Gene:
- OSBPL3 NIH gene
- Name:
- oxysterol binding protein like 3
- Previous symbol:
- OSBP3
- Synonyms:
- ORP-3, ORP3, KIAA0704
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-10
- Date modifiied:
- 2015-11-16
Related products to: OSBPL3 Blocking Peptide
Related articles to: OSBPL3 Blocking Peptide
- Prolonged activation of hepatocyte transforming growth factor β (TGFβ) signaling has been identified as a key driver of hepatic stellate cell activation, leading to liver fibrosis in chronic liver diseases. However, the mechanisms by which overactivation of TGFβ signaling within hepatocytes promotes hepatic stellate cell activation and liver fibrosis remain poorly understood. The expression of OSBPL3, enconding oxysterol-binding protein-related protein 3 (ORP3), is markedly induced in human fatty liver samples. However, the regulation and function of hepatic ORP3 in the pathogenesis of liver fibrosis are currently unknown. - Source: PubMed
Publication date: 2026/07/03
Gao JiashiZhang GaryWang SujuanZhao YueeZhao QiqianHu ZhenZhang JianCooke SarahTong XinYin Lei - Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, plays a pivotal role in chondrocyte death and the pathogenesis of osteoarthritis (OA). Taurine, a sulfur-containing amino acid with established anti-inflammatory and anti-ferroptotic properties, has been implicated in joint protection; however, its potential to mitigate OA progression by targeting ferroptosis mechanisms remains largely unexplored. - Source: PubMed
Publication date: 2026/06/30
Luo XiaofeiZhou XuchangWang YuehuiLi ZheChen XierWei XuanNi Guoxin - Colorectal cancer (CRC) is the third most common cancer worldwide, with prognosis often limited by disease progression. The role of oxysterol-binding protein-like 3 (OSBPL3) in various cancers remains unclear. This study aimed to investigate the expression, biological function, and relationship of OSBPL3 with the tumor microenvironment (TME) in CRC, and to assess its potential as a therapeutic target. - Source: PubMed
Publication date: 2026/04/24
Liang WeijunWang ChengxingWei JianchangZhou ChaorongHe CanxiuHe YaomingZhao JinglinLi ShangrenCao Jie - Fat deposition plays a crucial role in regulating the production performance and meat quality of broilers. Although the heterogeneity of mammalian adipocytes has been extensively studied, research on the molecular mechanisms underlying differences in lipid droplet accumulation in avian adipocytes remains limited. This study confirmed a significant positive correlation (R > 0.81, < 0.001) between the SSC signal and lipid droplet content via fluorescence staining of lipid droplets, Oil Red O staining, and triglyceride (TG) quantification. Based on this, a label-free sorting strategy using SSC signals was established to sort differentiated chicken preadipocytes, obtaining high lipid droplet (H) and low lipid droplet (L) subpopulations, which were subsequently subjected to transcriptome sequencing and differential gene expression (DEG) analysis, followed by GO and KEGG enrichment analysis. The results indicated no significant differences in the expression of adipogenesis marker genes (, , , , ) between the high lipid droplet (H) and low lipid droplet (L) groups, suggesting that both groups are at similar stages of differentiation. KEGG analysis revealed that both the H vs. NC and L vs. NC comparisons were enriched in common pathways, including the PPAR signaling pathway, ECM-receptor interaction, focal adhesion, cytokine-receptor interaction, and calcium-Apelin signaling pathway, suggesting that both groups of cells had activated the adipogenesis program. GO analysis showed that, in both H vs. NC and L vs. NC comparisons, differentially expressed genes (DEGs) were enriched in biological processes (BPs) related to cell adhesion, nucleosome assembly, chromatin remodeling, and receptor activity, as well as cellular components (CCs) such as the extracellular matrix, cytoskeleton, and nucleosome organization, indicating extensive gene reprogramming and activation of signaling transduction during differentiation. In the H vs. L comparison, enriched pathways included ABC transporters, ECM-receptor interaction, focal adhesion, gap junctions, microtubule-related processes, and neuroactive ligand-receptor interactions, involving lipid transmembrane transport, cytoskeleton stabilization, and signal transduction regulation, suggesting that high lipid droplet cells are more mature in lipid droplet transport, storage, and homeostasis maintenance. GO enrichment results further supported this conclusion, as H vs. L specifically enriched processes related to microtubule-related processes, cell cycle, and redox reactions (BPs), as well as chromosome organization, cytoskeleton, and motor activity (CC/MF), indicating that high lipid droplet cells maintain lipid droplet fusion and metabolic homeostasis via enhanced microtubule transport and antioxidant regulation. Differential gene analysis revealed that the L group upregulated genes associated with fatty acid synthesis and elongation (, , , , ), cholesterol and isoprenoid biosynthesis (, , , , , , ), and fatty acid oxidation (, , , ), reflecting a metabolic characteristic of concurrent lipid synthesis and mobilization; the H group, conversely, upregulated genes associated with lipid droplet formation and storage (, , , , ), lipid transport (, , , , ), and antioxidant defense (, , ), exhibiting a storage and homeostasis-oriented metabolic state. In the NC, L, and H groups, the expression of five genes-, , , , and -showed a gradual increase, suggesting that these genes were associated with preadipocyte differentiation and lipid droplet deposition. In summary, although the high and low lipid droplet subpopulations of chicken preadipocytes exhibit similar differentiation states, they form distinct metabolic orientations. The L group is characterized by active lipid synthesis, fatty acid oxidation, and membrane lipid remodeling, while the H group predominantly features lipid droplet storage, lipid transport, and antioxidant homeostasis. This study highlights the molecular mechanisms underlying the metabolic heterogeneity of avian adipocytes and provides a theoretical basis for poultry fat deposition regulation and genetic improvement. - Source: PubMed
Publication date: 2026/03/12
Wang BoyuLi YantaoWang YakeChen JiayiWang JialiLi XiaopingLi Zhenhui - As a member of the oxysterol-binding protein-like (OSBP) family, which is primarily involved in lipid transport and metabolic regulation, Oxysterol-binding protein-like protein 3 (OSBPL3), has garnered increasing attention due to its abnormal expression and functional roles in various cancers. However, the specific role and molecular mechanisms of OSBPL3 in pancreatic cancer (PDA) remain unclear. - Source: PubMed
Publication date: 2026/02/18
Sun QihuiLi XiaojiaZou QiChen YangZhu XiaoqiJiang HailinJiang TingtingWei FangXie Keping