Ask about this productRelated genes to: TRAM2 Blocking Peptide
- Gene:
- TRAM2 NIH gene
- Name:
- translocation associated membrane protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0057
- Chromosome:
- 6p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-03
- Date modifiied:
- 2016-10-05
Related products to: TRAM2 Blocking Peptide
Related articles to: TRAM2 Blocking Peptide
- Ovarian cancer (OC) ranks among the most prevalent malignant tumors in women, contributing significantly to mortality rates. This disease exhibits considerable heterogeneity, characterized by intricate molecular and genetic alterations. Ferroptosis, a distinct form of cell death, has emerged as a critical factor in various cancers, including OC. However, the regulatory mechanisms underlying ferroptosis in OC patients remain unclear and require further investigation. This study aimed to identify lncRNA associated with OC and elucidate the underlying mechanisms through bioinformatics methods and experimental validation. Ferroptosis-related lncRNAs (FRLs) was identified in OC, and its prognostic value was assessed using univariate Cox analysis. Additionally, the molecular subtypes of FRLs were evaluated through the ConsensusClusterPlus software package. Notably, Cluster 2 exhibited a low TME score, which was linked to a poorer prognosis. The GSEA suggested that Cluster 2 shared similarities with other clusters associated with worse survival outcomes, likely due to the activation of tumor-associated pathways. In vitro experiments further confirmed that certain lncRNAs could be upregulated under ferroptotic conditions. We focused on two lncRNAs, AC027348.1 and TRAM2-AS1, which were not noticed before and were significantly upregulated, to explore their regulatory effects on ferroptosis. The underlying mechanisms were preliminarily investigated through transcriptome sequencing. In summary, our findings offer new insights into the pathogenesis of OC, particularly regarding the role of lncRNAs related to ferroptosis. - Source: PubMed
Li QianruLv MengyaoZhang AijieLiu XueLu WantingShao MinCao Limian - Autism spectrum disorder (ASD) is a childhood-onset complex neurodevelopmental disorder. We carried out a comprehensive genetic study of a quadruplet discordant for ASD to identify the candidate genes of ASD. Whole exome sequencing (WES) was done for the quadruplet and their parents. We identified 218 proband-specific de novo single nucleotide variants (SNVs) and 100 indels, none of which were deleterious. Among these, nine SNVs and six indels are reported in autism databases. A homozygous recessive non-synonymous SNV in TRAM2, and a pair of compound heterozygous non-synonymous SNVs in DGKD, all of which were proband-specific, were predicted to be deleterious. These are novel candidate genes for ASD. Genes harboring proband-specific de novo and inherited variants were enriched in the biological processes related to synaptic transmission and neurodevelopment. This is the first genetic study of a quadruplet in ASD. - Source: PubMed
Publication date: 2025/02/07
Anitha AyyappanBanerjee MoinakThanseem IsmailMelempatt NishaPrakash AnilIype MaryThomas Sanjeev V - Glioma is the most common and aggressive malignant tumors in central nervous system, its morbidity and mortality are both high. Lysine acetylation could alter the expression of oncogene and anti-oncogene. Thus, this study explored the potential mechanism and aimed to find new diagnostic and therapeutic methods. The Cancer Genome Atlas Glioblastoma Multiforme, Glioma related dataset were downloaded from UCSC and CGGA database respectively. Lysine acetylation-related genes (LARGs) was acquired from published literature. Differentially expressed genes (DEGs) were analyzed between GBM and control samples. LARGs (DE-LARGs) were obtained by taking the intersection of DEGs and weighted gene co-expression network analysis (WGCNA) module genes. Subsequently, enrichment analysis and protein-protein interaction (PPI) network was processed. Then, prognosis genes were selected, risk model was constructed and verified. After that, independent prognosis factors were used to predict the survival of GBM patients. Corresponding pathways and functions were analyzed between different groups. The difference of immune environment was compared. Finally, the drug prediction and regulatory network construction was performed. Prognosis genes in tumor and normal tissue were identified using immunohistochemistry. Totally 6767 DEGs were screened out. A total of 2890 module genes were identified highly correlated with lysine acetylation score by WGCNA. A total of 313 DE-LARGs were acquired by taking the intersection of DEGs and module genes. PPI network was constructed and 215 genes were obtained. Further, risk model revealed 5 genes (CD79B, STXBP4, DDHD1, FKBP1B and TRAM2) was related with overall survival (OS) of GBM patients. Kaplan-Meier survival and receiver operating characteristic curves were proved to be highly accurate both in training and validation set. Based on nomogram, riskscore was the independent prognosis factor for patients. The immune infiltration level was highly expressed in high risk group. Four drugs (PAC.1, OSI.906, WH.4.023, BMS.536924) were identified as chemotherapeutic drugs in Glioma. The transcription factors (TFs)-mRNA regulatory network was constructed and 76 TFs were obtained using TRRUST. Finally, the expression of prognostic genes in tumor was significantly higher than that in normal tissue. New prognostic genes CD79B, STXBP4, DDHD1, FKBP1B, and TRAM2 were identified for glioma through the new perspective of lysine acetylation, suggesting their importance in the development of the disease and offering potential insights for diagnosis and treatment. - Source: PubMed
Publication date: 2025/07/01
Zhou MinWang BingLiang RichuLuan Xinping - Pancreatic cancer (PC) is amongst the most lethal gastrointestinal tumors, which is the seventh leading reason of cancer-related mortality worldwide. Previous studies have indicated that circular RNAs (circRNAs), which is a new type of endogenous noncoding RNA (ncRNA), can mediate tumor progression in diverse tumor types including PC. Whereas precise roles regarding circRNAs and their underlying regulatory mechanisms in PC remain unknown. - Source: PubMed
Publication date: 2023/04/11
Li ChaoCai JuanjuanLiu WeifengGao ZhenzhenLi Guogang - Glycolysis and cholesterol synthesis are crucial in cancer metabolic reprogramming. The aim of this study was to identify a glycolysis and cholesterol synthesis-related genes (GCSRGs) signature for effective prognostic assessments of osteosarcoma patients. - Source: PubMed
Publication date: 2022/12/23
Xu FangxingYan JinglongPeng ZhibinLiu JingsongLi Zecheng