Ask about this productRelated genes to: PAXIP1 Blocking Peptide
- Gene:
- PAXIP1 NIH gene
- Name:
- PAX interacting protein 1
- Previous symbol:
- PAXIP1L
- Synonyms:
- CAGF29, CAGF28, TNRC2, PTIP
- Chromosome:
- 7q36.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-25
- Date modifiied:
- 2016-10-05
- Gene:
- PAXIP1-AS2 NIH gene
- Name:
- PAXIP1 antisense RNA 2
- Previous symbol:
- PAXIP1OS
- Synonyms:
- -
- Chromosome:
- 7q36.2
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2013-07-23
- Date modifiied:
- 2014-10-03
Related products to: PAXIP1 Blocking Peptide
Related articles to: PAXIP1 Blocking Peptide
- Clear cell renal cell carcinoma (ccRCC) is the most invasive type of cancer, with a high risk of metastasis and recurrence. Therefore, there is an urgent need to identify novel prognostic predictors and therapeutic targets of ccRCC. Activating transcription factor 3 (ATF3), a tumor oncogene or repressor, has rarely been examined in ccRCC. In the present study, we comprehensively elucidate the prognostic value and potential functions of ATF3 in ccRCC. Several TCGA-based online databases were used to analyze ATF3 expression in ccRCC and determine ccRCC prognosis. The upstream-binding micro (mi) RNAs of ATF3 and long non-coding (lnc)RNAs were predicted using the StarBase database. Analysis of several TCGA-based online databases showed that ATF3 expression is decreased in ccRCC, suggesting a significant association with the prognosis of patients with ccRCC. Furthermore, we found hsa-miR-221-3p to be potential regulatory miRNA of ATF3 in ccRCC. Prediction and analysis of the upstream lncRNAs indicated that PAXIP1-AS2 and OIP5-AS1 were the most potent upstream lncRNAs of the hsa-miR-221-3p/ATF3 axis in ccRCC. The results of the GO and KEGG analyses implied that ATF3 is likely involved in the regulation of apoptotic signaling in response to endoplasmic reticulum (ER) stress in ccRCC. Correlation analysis revealed a positive relationship between ATF3 expression and ER stress. Our in silico findings highlighted that ATF3 expression was low in ccRCC and negatively correlated with poor prognosis. Furthermore, PAXIP1-AS2 and the OIP5-AS1/hsa-miR-221-3p/ATF3 axis were identified as significant potential regulators of ER stress-mediated apoptosis in ccRCC. - Source: PubMed
Yang ZhicongHou YongwangLi JingqiXu DandanYang ZhichaoWang Xinsheng - TENT4A (PAPD7) is a non-canonical poly(A) polymerase, of which little is known. Here, we show that TENT4A regulates multiple biological pathways and focuses on its multilayer regulation of translesion DNA synthesis (TLS), in which error-prone DNA polymerases bypass unrepaired DNA lesions. We show that TENT4A regulates mRNA stability and/or translation of DNA polymerase η and RAD18 E3 ligase, which guides the polymerase to replication stalling sites and monoubiquitinates PCNA, thereby enabling recruitment of error-prone DNA polymerases to damaged DNA sites. Remarkably, in addition to the effect on RAD18 mRNA stability via controlling its poly(A) tail, TENT4A indirectly regulates RAD18 via the tumor suppressor CYLD and via the long non-coding antisense RNA , which had no known function. Knocking down the expression of or , or overexpression of led each to reduced amounts of the RAD18 protein and DNA polymerase η, leading to reduced TLS, highlighting as a new TLS regulator. Bioinformatics analysis revealed that TLS error-prone DNA polymerase genes and their -related regulators are frequently mutated in endometrial cancer genomes, suggesting that TLS is dysregulated in this cancer. - Source: PubMed
Publication date: 2021/06/28
Swain UmakantaFriedlander GilgiSehrawat UrmilaSarusi-Portuguez AvitalRotkopf RonEbert CharlottePaz-Elizur TamarDikstein RivkaCarell ThomasGeacintov Nicholas ELivneh Zvi - Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, the prognostic value of ferroptosis-related lncRNAs has never been comprehensively explored in glioma. In this study, the transcriptomic data and clinical information of glioma patients were downloaded from TCGA, CGGA and Rembrandt databases. We identified 24 prognostic ferroptosis-related lncRNAs, 15 of which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844, MIR155HG, MIR22HG, PVT1, SNHG18, PAXIP1-AS2, and SBF2-AS1) were used to construct a ferroptosis-related lncRNAs signature (FRLS) according to the least absolute shrinkage and selection operator (LASSO) regression. The validity of this FRLS was verified in training (TCGA) and validation (CGGA and Rembrandt) cohorts, respectively. The Kaplan-Meier curves revealed a significant distinction of overall survival (OS) between the high- and low-risk groups. The receiver operating characteristic (ROC) curves exhibited robust prognostic capacity of this FRLS. A nomogram with improved accuracy for predicting OS was established based on independent prognostic factors (FRLS, age, and WHO grade). Besides, patients in the high-risk group had higher immune, stroma, and ESTIMATE scores, lower tumor purity, higher infiltration of immunosuppressive cells, and higher expression of immune checkpoints. Patients in the low-risk group benefited significantly from radiotherapy, while no survival benefit of radiotherapy was observed for those in the high-risk group. In conclusion, we identified the prognostic ferroptosis-related lncRNAs in glioma, and constructed a prognostic signature which was associated with the immune landscape of glioma microenvironment and radiotherapy response. - Source: PubMed
Publication date: 2021/05/19
Zheng JianglinZhou ZijieQiu YueWang MinjieYu HaoWu ZhipengWang XuanJiang Xiaobing