Ask about this productRelated genes to: IFI44L Blocking Peptide
- Gene:
- IFI44L NIH gene
- Name:
- interferon induced protein 44 like
- Previous symbol:
- C1orf29
- Synonyms:
- GS3686
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-29
- Date modifiied:
- 2016-10-05
Related products to: IFI44L Blocking Peptide
Related articles to: IFI44L Blocking Peptide
- Systemic lupus erythematosus (SLE) frequently involves the hematologic system, and autoimmune hemolytic anemia (AIHA) is a severe and potentially life-threatening complication. Splenectomy has been regarded as a third-line treatment option for refractory AIHA; however, its role in SLE-associated AIHA, particularly in patients with atypical immunologic phenotypes, remains to be further clarified. Here, we report a patient with refractory SLE-associated AIHA who failed multiple lines of therapy and subsequently underwent splenectomy, after which the hemoglobin level gradually increased and sustained hematologic improvement was achieved during follow-up. Splenic pathology suggested that the spleen was not only a major site of erythrocyte destruction but also a key pathologic organ in sustaining abnormal immune responses and ongoing hemolysis. In addition, positive IFI44L methylation provided supplementary supportive evidence for an SLE-related immune background. This case suggests that splenectomy may still represent a therapeutic option worthy of careful consideration in patients with refractory SLE-associated AIHA who fail multiple lines of therapy. - Source: PubMed
Publication date: 2026/04/28
Pan XiaoliChen JuanLi ChunyanLin YupeiWang YuTian JingqiaoTian MeiLi Anmao - Chronic lung allograft dysfunction (CLAD) significantly limits long-term survival of lung transplant recipients, with viral infections acting as critical contributors to its pathogenesis. The mechanisms linking viral infections to CLAD-associated airway fibrosis remain incompletely understood. This study investigates the role of the type I interferon (IFN) master regulator IRF7 in virus-induced airway fibrogenesis. - Source: PubMed
Publication date: 2026/05/08
Banday Mudassir MRahman MizanurGoda YasufumiPotter Andrew SNaito TatsuhikoMallidi HaripriyaSurolia RanuLee StefiRehman RakhshindaLoor GabrielHayes DonSharma Nirmal S - Hashimoto's thyroiditis (HT) is a common disease characterized by autoimmune injury of the thyroid. Its pathogenesis entails complex interactions among hereditary predisposition, immune disorders and environmental factors. In recent years, viral infection has attracted much attention as a potential environmental trigger, but the role genes associated with HT remain unclear. - Source: PubMed
Publication date: 2025/07/24
Zhang YuhanWang HanyuFu MengfeiYang LiuYu LuChen XiaoWang SiqiWang YuWang ZixuanLiu JiaqiSun Hui - Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and hospitalization in infancy. Reliable biomarkers reflecting host antiviral responses and disease dynamics are still lacking. - Source: PubMed
Publication date: 2026/04/01
Galliano IlariaLiguori Stefania AlfonsinaPau AnnaMontanari PaolaCalvi CristinaClemente AnnaMassobrio AnnaLinari ClaudiaGambarino StefanoConio AlessandraBergallo Massimiliano - Bovine viral diarrhea virus (BVDV) strains of differing virulence are associated with distinct clinical and lymphoid outcomes, but transcriptional responses within peripheral lymphocyte compartments remain incompletely defined. Here, we performed RNA-seq on CD4/CD8β/TcR1 bead-enriched peripheral lymphocyte fractions from calves experimentally infected with low-virulence or high-virulence noncytopathic BVDV strains (BVDV2-RS886 and BVDV2-1373, respectively) and sampled on days 0, 3, and 15 days post-inoculation. Because group sizes were small (n = 3 per group), analyses were interpreted as exploratory. Marker-gene analyses indicated that the sequenced material represented a T-cell-enriched but compositionally heterogeneous peripheral lymphocyte fraction. At day 3, both infection groups showed strong induction of interferon-responsive genes, including OAS family members, ISG15, IFI44/IFI44L, RSAD2, DDX58, and ZBP1. The high-virulence group additionally showed broader reduction of transcripts associated with lymphocyte signaling, trafficking, and biosynthetic activity. By day 15, the low-virulence group showed only a small residual response, whereas the high-virulence group remained broadly perturbed, with reduced abundance of multiple adaptive immune and antigen-presentation-associated transcripts in the bead-enriched fraction. These data define divergent temporal transcriptomic trajectories associated with BVDV2 virulence and provide a hypothesis-generating resource for future studies using phenotypically defined bovine lymphocyte subsets. - Source: PubMed
Publication date: 2026/04/23
Bauermann Fernando VicosaBayles Darrell OFalkenberg Shollie MMaggioli Mayara FRidpath Julia F