FOXO3A Blocking Peptide
- Known as:
- FOXO3A Blocking Peptide
- Catalog number:
- 33r-5961
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- FOXO3A Blocking Peptide
Related genes to: FOXO3A Blocking Peptide
- Gene:
- FOXO3 NIH gene
- Name:
- forkhead box O3
- Previous symbol:
- FKHRL1, FOXO3A
- Synonyms:
- AF6q21, FOXO2
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-23
- Date modifiied:
- 2015-08-25
Related products to: FOXO3A Blocking Peptide
Related articles to: FOXO3A Blocking Peptide
- Autophagy plays a crucial role in maintaining cellular homeostasis and has been implicated in the pathogenesis of knee osteoarthritis (OA). However, data on radiographic stage-dependent transcriptional variation of autophagy-related genes in patients with knee OA, particularly using peripheral blood samples, remain limited. The aim of this study was to evaluate whether disease severity was associated with stage-dependent changes in the expression of selected autophagy-related genes within a patient cohort. - Source: PubMed
Ök Zeynep DündarGürbüz Muhammed ErdiÖk NusretLengerova GerganaBozhkova MartinaPetrov SteliyanKöseler Aylin - Muscle atrophy is a major feature of Limb Girdle Muscular Dystrophy R1 (LGMDR1) patients, but its underlying molecular mechanisms have not been fully explored. While the ubiquitin-proteasome system (UPS) is known to be involved in muscle protein degradation, inflammation commonly observed in LGMDR1 patients may further activate the UPS. This study aimed to explore the role of inflammation in the muscle atrophy of LGMDR1 patients. - Source: PubMed
Publication date: 2026/03/30
Banerjee SukanyaRadotra Bishan DassLuthra-Guptasarma ManniGoyal Manoj K - Cisplatin is a highly effective chemotherapeutic agent used to treat various solid tumors; however, its clinical utility is limited by dose-dependent nephrotoxicity. Perampanel, an AMPA-receptor antagonist FDA-approved anti-seizure drug, has recently shown inhibitory effects on oxidative stress and inflammasome-mediated pyroptosis in neurological damage models. The current work examined the possible renoprotective benefits and clarified the underlying molecular signaling modified by perampanel in a cisplatin-renal injury model. Male Wistar rats were used to investigate the effect of perampanel (1 & 2 mg/kg/day, for 14 days) against renal injury induced by cisplatin (10 mg/kg, on the 9th day), followed by morphological, histopathological, immunohistochemical (IHC), and biochemical estimations. The administration of perampanel to cisplatin-injected rats maintained the kidney-to-body weight ratio and renal function in a dose-dependent manner. Besides, there was a great improvement in the histological features compared to the cisplatin group. IHC analysis revealed the efficient inhibitory impact of perampanel against cisplatin-induced upregulation of NF-κB p65, NLRP3, and caspase-1 expressions. Consequently, the activation of interleukin (IL)-18 and -1β inflammatory cytokines was interrupted, and their renal levels were not elevated. Eventually, the pyroptosis effector protein, gasdermin D (GSDMD), upregulation was impeded. Inflammasome inhibition by perampanel was accompanied by downregulation of the promoter signaling NF-κB p65/TNF-α, enhancement of sirtuin 3/FOXO3 antioxidant signaling alongside upregulated Nrf-2 mRNA expression and antioxidant proteins, as well as maintained balance of Bax/Bcl-2; pro-/anti-apoptotic; genes. Collectively, perampanel could attenuate cisplatin-induced renal injury through its inhibitory influence on NF-κB p65/TNF-α and NLRP3-mediated pyroptosis, in addition to enhancement of antioxidant defense and controlling apoptosis. - Source: PubMed
Publication date: 2026/04/25
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