Ask about this productRelated genes to: PHF11 Blocking Peptide
- Gene:
- PHF11 NIH gene
- Name:
- PHD finger protein 11
- Previous symbol:
- -
- Synonyms:
- NY-REN-34, BCAP, IGER
- Chromosome:
- 13q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-08
- Date modifiied:
- 2016-10-05
Related products to: PHF11 Blocking Peptide
Related articles to: PHF11 Blocking Peptide
- Alopecia areata (AA) is a chronic autoimmune-mediated disorder characterized by hair loss from the scalp and/or body. AA patients frequently present with comorbid chronic inflammatory disorders (CIDs), particularly atopic and autoimmune diseases. Genome-wide association (GWA) studies have suggested a genetic link. However, no studies to date have examined genetic factors that are associated with the comorbid development of CIDs directly in individuals affected by AA. - Source: PubMed
Publication date: 2026/04/17
Herrera-Rivero MarisolGossmann YasminaAwasthi SwapnilCesarato NicoleRipke StephanBlaumeiser BettinaBlume-Peytavi UlrikeLutz GerhardRedler SilkeNöthen Markus MBetz Regina CBasmanav F Buket - Visceral white-nodule disease (VWND), caused by Pseudomonas plecoglossicida, poses a significant threat to the development of the Larimichthys crocea aquaculture industry. Breeding disease-resistant strains offers a potential solution, but the underlying mechanisms of disease resistance in L. crocea remain unclear, and relevant functional markers are still lack. In the present study, 243 full-sibling F populations of L. crocea were infected with P. plecoglossicida. Whole-genome resequencing, bulk segregant analysis (BSA) mapping, and spleen transcriptome analysis were performed on two extreme phenotype pools, which defined by survival time (AT) and spleen bacterial load (BL) as disease-resistance indicators. Candidate genes were validated through infection experiments. A total of 5,576,771 SNPs were identified, and Δ(SNP-index), Euclidean distances (ED), and G-statistics were applied to locate two stable disease resistance-related QTLs on Chr 02 (2.6 Mb) and Chr 24 (4.9 Mb) with 99 % confidence, containing 278 candidate genes. Transcriptomic analysis revealed 4811 genes involved in the immune response, with 949 genes linked to P. plecoglossicida resistance variation in L. crocea. Integrated analysis identified 17 core immune gene, and subsequent validation confirmed that 6 genes (Phf11, CYBB, PTK2B, STAT1, Adamts1, and NRP2) play a consistent role in L. crocea resistance. Our findings highlight the utility of BSA-seq for genetic analysis of disease resistance and provide insights for molecular-assisted breeding in L. crocea. - Source: PubMed
Publication date: 2025/06/28
Ye TingLiu FengLiang XiaoGuo DandanZhan WeiShao GuoerLou Bao - To demonstrate the efficacy of machine learning models in predicting mortality in melanoma cancer, we developed an interpretability model for better understanding the survival prediction of cancer. To this end, the optimal features were identified, ten different machine learning models were utilized to predict mortality across various datasets. Then we have utilized the important features identified by those machines learning methods to construct a new model named NKECLR to forecast mortality of patient with cancer. To explicitly clarify the model's decision-making process and uncover novel findings, an interpretable technique incorporating machine learning and SHapley Additive exPlanations (SHAP), as well as LIME, has been employed, and four genes EPGN, PHF11, RBM34, and ZFP36 were identified from those machine learning(ML). The experimental analysis conducted on training and validation datasets demonstrated that the proposed model has a good performance com- pared to existing methods with AUC value 81.8%, and 79.3%, respectively. Moreover, when combined our NKECLR with PD-L1, PD-1, and CTLA-4 the AUC value was 83%0. Finally, these findings have been applied to comprehend the response of drugs and immunotherapy. Our research introduced an innovative predictive NKECLR model utilizing natural killer(NK) cell marker genes for cohorts with melanoma cancer. The NKECLR model can effectively predict the survival of melanoma cancer cohorts and treatment results, revealing distinct immune cell infiltration in the high-risk group. - Source: PubMed
Publication date: 2024/12/04
Hounye Alphonse HoussouXiong LiHou Muzhou - Long noncoding RNA (lncRNAs) are involved in the pathogenesis of ulcerative colitis (UC). Moxibustion, a traditional Chinese medicine, can improve symptoms in patients with UC and reduce intestinal inflammation in rats with UC. However, it remains unclear whether the ameliorative effect of moxibustion on intestinal mucosal inflammation in UC is related to lncRNAs. Thirty-two rats were randomly assigned to four groups: normal control, UC, moxibustion (MOX), and sulfasalazine (SASP). The UC rat model was induced by administering 4% dextran sulfate sodium (DSS) in drinking water. Rats in the moxibustion group underwent bilateral Tianshu (ST25) moxibustion using the herbs-partition moxibustion method. Rats in the sulfasalazine group received SASP solution gavage twice daily for seven consecutive days. Our results revealed that, compared with the UC group [2.00 (1.00, 2.50)], the DAI score [0.25 (0.00, 0.50)] was significantly lower in the MOX group ( < 0.05). Compared with the UC group [13.00 (11.25, 14.00)], the histopathological score [5.50 (4.00, 7.75)] was significantly lower in the MOX group ( < 0.05). In addition, the CMDI and macroscopic scores were decreased in the MOX group ( < 0.05). Moxibustion significantly decreased the protein expression of inflammatory factors TNF-α, IFN-γ, and IL-1β in the colonic tissues of UC rats (0.05), thereby suppressing the inflammatory response. Moreover, moxibustion exerted a regulatory influence on colon lncRNA and mRNA expression profiles, upregulating LOC108352929 and downregulating Phf11 in rats with UC (0.05). Moxibustion also led to a reduction in the expression and colocalization of Phf11 and NF-κB in the colons of UC rats. Moreover, knockdown of LOC108352929 in rat enteric glial cells demonstrated a significant upregulation of TNF-α mRNA expression (0.05). In summary, these data illustrate that moxibustion effectively ameliorates DSS-induced colonic injury and inflammation while exerting regulatory control over the lncRNA-mRNA co-expression network in UC rats. Collectively, the and studies suggested that LOC108352929-Phf11 may serve as a potential biological marker for moxibustion in the treatment of UC. - Source: PubMed
Publication date: 2024/02/23
Li GuonaZhao ChenXu JingHuang YanQiao YuLi FengPeng GuangbinZheng ShiyuZhu LuYang LingWang ZhaoqinWu Huangan - Endometriosis (EMS) is a prevalent disease and the etiologies has not uniform. Microbiota is associated with human diseases. To delve into the relationship between EMS and microbiota, Ectopic (EM) and eutopic (EU) endometrial tissues, pharyngeal swabs, and stools were collected from EMS patients. The microbiota composition of EM and EU partially overlapped, with similar taxon numbers and diversity, but the richness levels were significantly different. A comparison of intestinal microbes in healthy individuals (FN) and EMS patients (FE) revealed that the richness of Enterococcus, Pseudomonas, Haemophilus, and Neisseria was enhanced in FE. In addition, Enterococcus-induced mice (EFA) presented with a higher degree of lesion infiltration and a wider distribution of lesions. Proteomic analysis revealed the expression of plant homeodomain finger 11 (PHF11) was notably downregulated in EFA. And the downregulated expression of PHF11 was accompanied by the upregulated expression of interleukin 8 (IL-8). Our findings suggest a potential regulatory mechanism for PHF11 in EMS development. - Source: PubMed
Publication date: 2023/10/07
Hu JingjingLi GuanjianHuang MiaomiaoShen QunshanGu HaoXue NairuiZhang JunqiangXu XiaofengYang WenjuanXing AyingWu XiaoWang YingWu RongXu ChuanLi YuqianFang YuanCao Yunxia