Ask about this productRelated genes to: SAAL1 Blocking Peptide
- Gene:
- SAAL1 NIH gene
- Name:
- serum amyloid A like 1
- Previous symbol:
- -
- Synonyms:
- FLJ41463
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-28
- Date modifiied:
- 2015-11-20
Related products to: SAAL1 Blocking Peptide
Related articles to: SAAL1 Blocking Peptide
- Metabolic reprogramming, particularly toward oxidative phosphorylation (OXPHOS), is a hallmark of lung squamous cell carcinoma (LUSC) and contributes to its aggressive phenotype and immunosuppressive microenvironment. While OXPHOS activation is increasingly recognized as a key metabolic feature in LUSC, its prognostic implications and associated gene signatures remain underexplored. This study aimed to identify OXPHOS-related differentially expressed genes (DEGs) and construct a robust prognostic signature for LUSC. - Source: PubMed
Publication date: 2025/12/04
Dai NinghuangFang ChenGu YuWang BinFeng WeiPan KaifangJiang WeiLi GuangbinMa Haitao - Palbociclib, a dual CDK4/6 kinase inhibitor used for breast cancer, has been explored as a treatment option for rheumatoid arthritis (RA). Preclinical studies have reported palbociclib-induced myelosuppression, but no such effects have been observed in or single-deficient mice. Synoviocyte proliferation-associated in collagen-induced arthritis 1/serum amyloid A-like 1 (SPACIA1/SAAL1) is involved in G1 phase progression. Given that SPACIA1/SAAL1 upregulates (but not ) expression, we aimed to determine whether suppressing CDK6 expression alone could prevent synovial hyperplasia without myelosuppression. The effects of CDK6 expression on TNF-α-induced rheumatoid arthritis synovial fibroblast (RASF) proliferation and synovial hyperplasia in collagen-induced arthritis (CIA) mice were investigated by modulating the transcriptional level with a expression inhibitor (indole-3-carbinol), small interfering RNA (siRNA), and -deficient mice. Indole-3-carbinol or siRNA inhibited TNF-α-induced RASF proliferation without suppressing CDK4 expression and reduced retinoblastoma protein phosphorylation. In CIA mice, indole-3-carbinol did not cause myelosuppression, considerably delayed CIA onset and progression, and reduced arthritis severity. -deficient mice showed similar improvements in CIA pathogenesis but had lower serum anti-type II collagen IgG levels. Notably, synovial hyperplasia was not observed in -deficient mice. CIA-synovial hyperplasia depends on CDK6, but not CDK4, expression. - Source: PubMed
Publication date: 2025/01/28
Komatsu RieFujii RyojiOgasawara ToruSuzuki-Takahashi YukiChen SandySugishita YodoNiki HisateruYudoh Kazuo - Lung adenocarcinoma (LUAD) carries a poor prognosis at advanced stages underscoring the need to elucidate the underlying molecular mechanisms driving its pathogenesis. This study aimed to investigate the roles of eukaryotic translation initiation factor 3 subunit M () and its associated effector, serum amyloid A-like 1 (), in LUAD development and progression. Bioinformatic analyses such as TNMplot, The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and other public databases were used to evaluate and expression levels, methylation status, clinical associations, and potential transcriptional regulators across LUAD datasets. Patient samples were analyzed for / expression by qRT-PCR, immunohistochemistry, and ELISA. and were overexpressed in LUAD tumor tissues compared with normal lung tissues, correlated with advanced stage, nodal metastasis, and poor survival outcomes. High / levels associated with increased cell proliferation, epithelial-mesenchymal transition, metastasis, and regulatory T cell dysfunction based on gene set enrichment analysis (GSEA). Mechanistically, / upregulation was linked to promoter hypomethylation, and transcriptionally regulated by JMJD1C, via hTFtarget prediction. The / promote oncogenic cellular programs and immunosuppressive microenvironments that conferred unfavorable prognosis. These findings nominate EIF3M/SAAL1 as potential therapeutic targets and biomarkers in LUAD. - Source: PubMed
Publication date: 2024/10/15
Chiang Hung-HsingWu Kuan-LiTsai Hung-PeiOng Chai-TungChang Chao-YuanWu Yu-YuanShen Tzu-YenHung Jen-YuLee Hsiao-ChenHsu Ya-LingTsai Ying-Ming - Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) remains unclear. Therefore, this study surveyed the worth and pathway of SAAL1 in LAC progression and immunity. - Source: PubMed
Publication date: 2023/03/27
Tong SongJiang NiWan Jun-HaoChen Chong-RuiWang Si-HuaWu Chuang-YanGuo QiangXiao Xiao-YueHuang HuanZhou Ting - Green feed diet in ruminants exerts a beneficial effect on rumen metabolism and enhances the content of milk nutraceutical quality. At present, a comprehensive analysis focused on the identification of genes, and therefore, biological processes modulated by the green feed in buffalo rumen has never been reported. We performed RNA-sequencing in the rumen of buffaloes fed a total mixed ration (TMR) + the inclusion of 30% of ryegrass green feed (treated) or TMR (control), and identified differentially expressed genes (DEGs) using EdgeR and NOISeq tools. - Source: PubMed
Publication date: 2023/03/20
Salzano AngelaFioriniello SalvatoreD'Onofrio NunziaBalestrieri Maria LuisaAiese Cigliano RiccardoNeglia GianlucaDella Ragione FlorianaCampanile Giuseppe