Ask about this productRelated genes to: TIMELESS Blocking Peptide
- Gene:
- TIMELESS NIH gene
- Name:
- timeless circadian regulator
- Previous symbol:
- -
- Synonyms:
- hTIM, TIM, TIM1
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-08
- Date modifiied:
- 2017-10-02
Related products to: TIMELESS Blocking Peptide
Related articles to: TIMELESS Blocking Peptide
- Childhood asthma is a common inflammatory airway disease, and its occurrence is influenced by environmental factors. Artificial light at night (ALAN) can disrupt circadian rhythms, but its relationship with childhood asthma remains unclear. To evaluate the association between ALAN and childhood asthma, and to investigate the role of the circadian clock gene in this relationship. - Source: PubMed
Publication date: 2026/04/23
Dai QiaoyanZhou FangxunLiu TieshuaiMa HanghaoZhou WeiYe QidongWang YingshuoHu Minfei - Substance use treatment and harm reduction strategies are vital tools in addressing the overdose crisis, however, effectiveness depends on access and uptake. Little is known about perceptions of harm reduction and substance use treatment efforts among people who use drugs (PWUD) in minoritized communities and how to enhance acceptability and uptake of evidence-based care. Our aim was to explore perceptions of drug use, PWUD and approaches to harm reduction and treatment in an urban, predominantly Black neighborhood heavily impacted by overdose. - Source: PubMed
Publication date: 2026/04/29
Barnes JasmineDavis M HollidayGallagher KathrynMorris KathrynO'Donnell NicoleGehri GillyPerrone JeanmarieLowenstein Margaret - Depressive symptoms in middle-aged and older adults are a worrying issue. Identifying core depressive symptoms in this population through network analysis is critical for the prevention, diagnosis, and treatment of depressive symptoms. - Source: PubMed
Publication date: 2026/04/12
Zhang LiyingJiang YiTong XueweiLiu MingxiaoWang WenchaoLiu LumingLiu AiyiWu XinchunLi Baixuan - Current acne management relies largely on topical and systemic pharmacotherapy, but these treatments frequently cause cutaneous adverse reactions. Such side effects are of particular concern in patients with initial skin sensitivity, highlighting the need for personalized approaches. - Source: PubMed
Han Ju HeeJu Hyun JeongKim Tae InYoon Young HoonWoo Young JunKye HeesangKim Jong YeobJeong Su JinBaek EunsunBae Jung Min - Activated oncogenes elicit genomic instability by inducing DNA replication stress. Here we show that replication fork reversal and chromosome mis-segregation induced by oncogenic RAS (HRASV12) or cyclin E1 overexpression are largely caused by co-transcriptional RNA:DNA hybrids (R-loops) formed during S-phase. Furthermore, we demonstrate that replication stress induced by HRASV12, but not cyclin E1, is driven by reactive oxygen species (ROS) in a manner dependent on the replisome-associated ROS sensor peroxiredoxin 2 (PRDX2) and is linked to PRDX2-mediated release of the fork acceleration factor TIMELESS from the replisome. Inhibition of fork reversal in cells overexpressing HRASV12 or cyclin E1 induces unrestrained DNA synthesis mediated by the MUS81 endonuclease and the primase-polymerase PRIMPOL, thereby promoting proper chromosome segregation in mitosis. These results establish PRIMPOL repriming as part of the MUS81-dependent replication restart mechanism that operates at sites of R-loop-mediated transcription-replication conflicts to maintain genomic stability. Furthermore, our data indicate that, despite their protective role during S-phase, persistent reversed forks impair chromosome segregation in mitosis, potentially leading to DNA breaks and chromosomal rearrangements. - Source: PubMed
Publication date: 2026/04/03
Oravetzova AnnaDvorakova MarketaMihai Anca-IrinaAndrs MartinSobol MargaritaZuev AntonShukla KaustubhBoleslavska BarboraRosano VinicioKönig ChristianeProkes JiriHanzlikova HanaMacurek LiborDobrovolna JanaJanscak Pavel