Ask about this productRelated genes to: SLC39A12 Blocking Peptide
- Gene:
- SLC39A12 NIH gene
- Name:
- solute carrier family 39 member 12
- Previous symbol:
- -
- Synonyms:
- FLJ30499
- Chromosome:
- 10p12.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-08
- Date modifiied:
- 2016-02-17
Related products to: SLC39A12 Blocking Peptide
Related articles to: SLC39A12 Blocking Peptide
- Investigating the genetic underpinnings of functional brain connectivity is essential to understand how genetic variation influences brain health and disease. Here, a mass-univariate approach was adopted to study the genetic architecture of functional brain circuitry (N = 28,159 subjects) with high spatial resolution (82 brain regions). Common genetic variants explained individual differences in 33% of all 3321 inter-regional functional pathways with 72 significant associations reflecting widespread, pleiotropic effects across the connectome. These associations were mapped to five genes-PAX8, EphA3, SLC39A12, THBS1 and APOE-with known associations with brain phenotypes and which converged in biological processes related to neurodevelopment and cardiovascular and cognitive traits (enrichment minimum p = 3.0 × 10 and p = 1.6 × 10, respectively). Our findings show that the genetic component of individual differences in functional brain connectivity is largely shared throughout the brain, highlighting the importance of genetic variation in large-scale brain organisation and its relationship with cognitive function and overall health. - Source: PubMed
Publication date: 2026/02/24
Maciel Bernardo de ApcSchipper MarijnRomero Catode Leeuw ChristiaanHelwegen KoenPosthuma DanielleSavage Jeanne Evan den Heuvel Martijn P - Fetal growth restriction (FGR) is a major contributor to perinatal morbidity and mortality, most commonly arising from placental dysfunction, with increasing evidence implicating aberrant DNA methylation in its pathogenesis. To identify robust epigenetic alterations associated with FGR, we analyzed placental chorionic villi from an in-house early-onset FGR cohort and compared them with a publicly available dataset (GSE100197). DNA methylation profiling was performed using Illumina EPIC (in-house) and 450K (public) arrays, processed with identical normalization and quality-control pipelines, including adjustment for gestational age and estimation of placental cell-type composition. Differentially methylated positions (DMPs) were identified using linear regression models, revealing 10,427 DMPs in the in-house cohort and 7467 in the public dataset, with 108 shared DMPs showing consistent direction of change across both cohorts. Promoter-associated DMPs were mapped to genes involved in angiogenesis, morphogenesis, immune regulation, and transcriptional control, including , , , , and , while additional novel candidates such as , , and family members were also identified. Functional annotation suggests that these methylation changes may influence pathways essential for placental vascular development and structural organization. Overall, this cross-cohort comparison highlights reproducible epigenetic signatures of FGR and underscores the need for standardized approaches to clarify the molecular mechanisms underlying placental insufficiency. - Source: PubMed
Publication date: 2026/01/31
Bednarek-Jędrzejek MagdalenaTaryma-Leśniak OlgaPoniatowska MałgorzataCejko MateuszMaksym KatarzynaDzidek SylwiaBlatkiewicz MałgorzataKwiatkowska EwaTorbé AndrzejKwiatkowski Sebastian - Nigrostriatal iron accumulation is a hallmark of ageing and neurodegenerative diseases, but the molecular mechanisms regulating iron deposition in the human brain remain unclear. Identifying genes linked to iron accumulation could reveal new pathways for neuroprotection and therapeutic targeting. - Source: PubMed
Publication date: 2025/12/10
Welton ThomasSaw Wuan TingZhou ZhidongSun QiaoyangMai Aaron ShengtingTeo Thomas Wei JunChan Ling-LingTan Louis Chew SengTan Eng-King - Synaptically released zinc is a neuronal signaling system that arises from the actions of the presynaptic vesicular zinc transporter protein zinc transporter 3 (ZnT3). Mechanisms that regulate the actions of zinc at synapses are of great importance for many aspects of synaptic signaling in the brain. Here, we identify the astrocytic zinc transporter protein ZIP12 as a candidate mechanism that contributes to zinc clearance at cortical synapses. We identify small-molecule compounds that antagonize the function of ZIP12 in heterologous expression systems, and we use one of these compounds, ZIP12 modulator 8, to increase the concentration of ZnT3-dependent zinc at synapses in the brain of male and female mice to inhibit the activity of neuronal AMPA and NMDA glutamate receptors. These results identify a cellular mechanism and provide a pharmacological toolbox to target the molecular machinery that supports the actions of synaptic zinc in the brain. - Source: PubMed
Publication date: 2025/03/26
Manning AbbeyMendelson Benjamin ZBender Philip T RBainer KaitlinRuby RayliShifflett Victoria RDariano Donald FWebb Bradley AGeldenhuys Werner JAnderson Charles T - Zinc transport proteins (ZIP and ZnT), metallothioneins (MT) and protein kinase CK2 are involved in dysregulation of zinc homeostasis in breast and prostate cancer cells. Following up our previous research, we targeted ZIP12, ZnT1, MT2A and CK2 in this study by investigating their expression levels and protein localisation. - Source: PubMed
Publication date: 2024/07/22
Barman Shital KNesarajah Abinaya NZaman Mohammad SMalladi Chandra SMahns David AWu Ming J