EIF2C3 Blocking Peptide
- Known as:
- EIF2C3 Blocking Peptide
- Catalog number:
- 33r-5810
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- EIF2C3 Blocking Peptide
Related genes to: EIF2C3 Blocking Peptide
- Gene:
- AGO3 NIH gene
- Name:
- argonaute RISC catalytic component 3
- Previous symbol:
- EIF2C3
- Synonyms:
- hAGO3, FLJ12765
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-26
- Date modifiied:
- 2019-02-01
Related products to: EIF2C3 Blocking Peptide
Related articles to: EIF2C3 Blocking Peptide
- Caelifera (Insecta: Orthoptera) exhibits remarkable genome size variation (0.97-21.48 Gb), primarily driven by massive expansions of transposable elements (TEs), which contribute to genomic gigantism. Although TE insertions can enhance genome plasticity, they are generally deleterious, leading to a continuous coevolutionary arms race with host silencing mechanisms. Here, we analyzed the genomes of ten Caelifera species (0.97-9.08 Gb) and found that significant genome expansion in Acridoidea coincides with multiple waves of TE bursts and a slow rate of TE loss. In species with gigantized genomes, we observed a rapid reduction in the number of C2H2-ZNF domains (KRAB-ZFPs host silencing factors) accompanied by shifts in amino acid preferences at TE-targeting positions. For the PIWI-clade evolution, small genomes were subjected to stronger purifying selection compared to gigantized genomes. Notably, in gigantized genomes, extensive TE insertions resulted in ultra-long introns (> 200 kb) in PIWI-clade genes, with significantly reduced transcript abundance, which may represent a mechanism for TE anti-silencing. Moreover, Ago3 mRNA elongation in gigantized genomes (primarily 3' UTR-expansion driven) coincides with reduced transcript abundance. Importantly, the ping-pong cycle results in a simultaneous increase in both retrotransposon transcript abundance and piRNA abundance during genome gigantism. However, the increased piRNA abundance may not be sufficient to silence a larger proportion of retrotransposons, leading to a lower retrotransposon silencing ratio and a higher number of active retrotransposons. These results advance our understanding of how TE-host silencing coevolution shapes genome expansion and maintains genomic stability in gigantized genomes. - Source: PubMed
Publication date: 2026/04/15
Liu XuanzengLi XiaoyuGan LijiaNie YimengJi YonghaoYin XiongyanYang LuHuang Yuan - Planarian flatworms are known for their remarkable regenerative capacity; however, the precise intercellular communication mechanisms underlying this process remain unsolved. Here, we report the discovery and characterization of abundant extracellular vesicles (EVs) in planarians. Using imaging and molecular analysis, we show conservation of biogenesis, morphology, and protein composition of planarian EVs. Environmental stressors significantly elevate EV release, indicating that planarians dynamically regulate vesicle production. Functionally, planarian EVs mediate intercellular communication by transferring regulatory signals: We find that they shuttle small RNAs that effect systemic RNA interference (RNAi) throughout the organism. Notably, gene knockdown experiments reveal a crucial role for AGO-3, a member of the Argonaute family of proteins, in modulating the association of small interfering RNAs with EVs, linking the intracellular RNAi machinery to EV-based signaling. These findings highlight EVs as pivotal mediators of cell-cell communication in planarians, with broad implications for understanding the coordination of gene regulation and tissue regeneration in animals. - Source: PubMed
Publication date: 2026/02/06
Sasidharan VidyanandAncellotti LauraDoddihal VirajBrewster CarolynMann FrederickMcKinney Mary CathleenVarberg JosephRoss EricDeng FengyanYi KexiSánchez Alvarado Alejandro - The high mutation rates of RNA virus replication generate genetically diverse virus variants in infected hosts. However, the effects of mutations on viral fitness and adaptability remain understudied in fungal-virus pathosystems. In this study, a novel hypovirus (single-stranded positive-sense RNA genome, family ), designated Valsa pyri hypovirus 1-α (VpHV1-α), and two of its shorter, less prevalent variants (VpHV1-β and VpHV1-γ), that contain different internal deletions in the N-terminal coding region of the viral protein, were identified in phytopathogenic fungal strains. Repeated subculture of a fungal strain infected with VpHV1-α produced VpHV1-β and VpHV1-γ, demonstrating that VpHV1-β and VpHV1-γ were generated by the deletion of the VpHV1-α genome. Compared to VpHV1-α and VpHV1-β, VpHV1-γ, which has a larger deletion, attenuated fungal growth and pathogenicity while accumulating to higher levels. However, it exhibited lower vertical transmission efficiency through spores. Intriguingly, unlike VpHV1-α and VpHV1-β, VpHV1-γ showed restricted horizontal transmission via hyphal anastomosis. This restriction was associated with the induction of programmed cell death and transcriptional activation of vegetative incompatibility-related genes upon VpHV1-γ infection. Additionally, VpHV1-γ infection upregulated key components of RNA silencing ( and ). Our results reveal a trade-off between viral accumulation and transmission efficiency, influencing the spread and persistence of VpHV1 variants in fungal populations. These findings provide new insights into viral evolution and host adaptation in natural fungal-virus ecosystems.IMPORTANCEStudies on mycoviruses are significant for advancing our understanding of viral evolution and host-pathogen interactions. In this study, we identified and characterized a novel hypovirus (VpHV1) infecting the plant-pathogenic fungus . VpHV1 exists as three viral variants (α, β, and γ). Notably, the γ variant, the least prevalent and shortest due to an internal genomic deletion, exhibited unique phenotypic traits: enhanced viral accumulation and symptom severity but impaired horizontal and vertical transmission. Intriguingly, infection by the γ variant induces programmed cell death during hyphal anastomosis with an isogenic fungal strain, thereby preventing viral transmission. This vegetative incompatibility-like reaction may represent a previously unknown defense mechanism in filamentous fungi, functioning to restrict viral spread within genetically homogeneous populations. Our findings demonstrate that transmission ability is a critical selective factor in viral evolution and adaptation within host populations. - Source: PubMed
Publication date: 2026/01/21
Yang ShianDai RuoyinLiu ShujingPang TianxingGong ShujuanTian MengyuanKang ZhenshengChen HongyingLuo MingAndika Ida BagusSun Liying - Pancreatic adenocarcinoma (PAAD) is an aggressive cancer type with high mortality rates. The Argonaute (AGO) gene/protein family is an evolutionary conserved family, which is responsible for post-transcriptional regulation of gene expression. Despite the fact that this family members (AGO1-4) have been linked to prognosis in some cancers, they have not been comprehensively investigated in PAAD. Therefore, this study investigates the role of AGO family members on PAAD. - Source: PubMed
Gulbey OzcanDuran Tugce - Obesity, characterized by excessive fat accumulation, represents a global health crisis closely linked to metabolic disorders such as type 2 diabetes, hypertension, and atherosclerosis. tRNA-derived small RNAs (tsRNAs) have recently emerged as important epigenetic regulators, yet their roles in fat deposition remain poorly characterized. This study aims to identify tsRNAs that influence fat accumulation and to elucidate their molecular mechanisms, with a focus on tRF‑Gly‑GCC‑037 (tRF‑Gly) as a candidate regulator of adipocyte differentiation. - Source: PubMed
Publication date: 2025/12/12
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