Ask about this productRelated genes to: PIGK Blocking Peptide
- Gene:
- PIGK NIH gene
- Name:
- phosphatidylinositol glycan anchor biosynthesis class K
- Previous symbol:
- -
- Synonyms:
- hGPI8, GPI8
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-17
- Date modifiied:
- 2015-11-06
Related products to: PIGK Blocking Peptide
Related articles to: PIGK Blocking Peptide
- Diabetic foot ulcer (DFU) is a complication of diabetes, characterized by impaired healing and chronic wounds that compromise quality of life. Migrasomes are newly discovered organelles involved in processes such as morphogenesis and angiogenesis, but their role in tissue repair and diabetic wound healing remains unknown. This study investigated the involvement of migrasomes in the pathogenesis and repair of DFU. - Source: PubMed
Publication date: 2026/03/30
Wang JieZhu MiaoJiang ZongzheLiao GuohuiXu CaiminJiang NanChen Qi - PIGK-related glycosylphosphatidylinositol (GPI) biosynthesis disorder is an extremely rare neurodevelopmental condition, with only 12 cases described to date. It is caused by biallelic mutations in the gene, which encodes a catalytic subunit of the GPI transamidase complex. This enzyme facilitates the attachment of GPI anchors to proteins crucial for cellular signaling and development. Eight of the 12 described cases were reported to have seizures, but the electroclinical characteristics are not well defined. - Source: PubMed
Publication date: 2026/01/30
Lateef ShanLewanda Amy FeldmanWeston JuliaBade SarahLessard Jacklyn - Glycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear. - Source: PubMed
Publication date: 2026/01/01
Yang Yi-FangLiao Jia-BinYu Pei-LunChou Chih-YuLin Yu-Hsuan - Peripheral nerve injury (PNI) is a major clinical challenge with limited effective therapeutic options. Our prior work has demonstrated that SJMHE1, a peptide derived from Schistosoma japonicum, promotes peripheral nerve regeneration by regulating M2 macrophages; however, its downstream molecular mechanisms remain unclear. Migrasomes are newly identified migration-dependent extracellular vesicles that mediate intercellular communication, and are abundantly produced by highly migratory macrophages. The present study investigates whether SJMHE1 promotes peripheral nerve regeneration through macrophage-derived migrasomes, with a focus on the role of these migrasomes in macrophage-Schwann cell crosstalk. - Source: PubMed
Publication date: 2025/11/11
Wang QianZhang WeiZhao KaiLiu YueWang ShangChen XingwenZhou DanWang JuanFeng YuLi TaoZhang WenchaoDong LiyangMa Yongbin - Colorectal Cancer (CRC) is a prevalent malignant tumor with a high incidence and mortality rate worldwide. Despite the availability of various treatment options, CRC remains a significant health challenge due to its complexity and heterogeneity. The objective of this study is to investigate the role of PIGK in CRC and to elucidate the underlying mechanisms that contribute to its impact on the disease. - Source: PubMed
Publication date: 2025/09/18
Lu DiLi XiaofangYuan YuanZhu YuanzengYang ZhiyuGuo HaifengWang JiannanZhang XiuLeiZhang QianZhou Bingxi