SC4MOL Blocking Peptide
- Known as:
- SC4MOL Blocking Peptide
- Catalog number:
- 33r-5780
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- SC4MOL Blocking Peptide
Related genes to: SC4MOL Blocking Peptide
- Gene:
- MSMO1 NIH gene
- Name:
- methylsterol monooxygenase 1
- Previous symbol:
- SC4MOL
- Synonyms:
- DESP4, ERG25
- Chromosome:
- 4q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-02-28
- Date modifiied:
- 2017-12-15
Related products to: SC4MOL Blocking Peptide
Related articles to: SC4MOL Blocking Peptide
- In recent years, the immunomodulatory role of adipose tissue (AT) has gained attention, yet the metabolic basis for immune homeostasis in AT remains unclear. Catecholamines (CAs) activate adipocyte β3-adrenergic receptors (β3-AR) to promote lipid metabolism, while cholesterol metabolism has bidirectional immunoregulatory properties. Whether the interaction between CAs and cholesterol regulates immune function in AT is unknown. Using chickens as models, we induced distinct immune states via dexamethasone (Dex) treatment and Newcastle disease virus (NDV) vaccination. Through qRT-PCR and metabolomics, we analyzed dynamic changes in lymphocytes, CAs, and cholesterol metabolism in AT. The results indicated that B cells were present in chicken AT and positively responded to different immune states through up-regulation. AT positively responded to Dex-induced immunosuppression (DIIS) and NDV-induced immune responses by altering cholesterol and CAs metabolisms. Moreover, the differences in cholesterol and CAs metabolisms were the key ways by which Dex affected immune response in AT. AT could synthesize bile acids and steroid derivatives, and secondary immunization possible was the key stage with active changes in cholesterol derivatives in AT. We identified a circuit pathway: "lymphocyte-catecholamine-adipocyte-cholesterol-cholesterol derivatives-lymphocyte," which may underpin immune microenvironment homeostasis in AT. Additionally, miR-206 was actively involved in the processes of DIIS, and the miR-206/MSMO1 pathway potentially regulated cholesterol metabolism in AT. This study provides a perspective for in-depth understanding of the immune regulation mechanism of AT and offer a direction for developing cholesterol derivatives for immune regulation. - Source: PubMed
Publication date: 2026/04/27
Li JiaJiang YiXia MeiqiZhang YuxinLin JiayiRen LiruWang XiangnanMan Chaolai - The quality of follicular development is a primary determinant of reproductive performance in female livestock and is governed by the functional state of granulosa cells (GCs). Androstenedione (ASD), a key steroid precursor converted within the ovary to estrogens and androgens via multiple pathways, has recognized biological roles. However, its direct regulatory actions in GCs and their consequences for sow fertility remain insufficiently defined. By comparing ovarian metabolomes from high and low reproductive performance sows, we pinpointed differentially abundant metabolites and prioritized ASD for mechanistic investigation. We then systematically characterized ASD function in primary porcine GCs in vitro and validated mechanisms using transcriptomics and gene overexpression. Our data support a model in which ASD acts via an ASD-MSMO1 axis and may engages canonical TGF-β, AMPK, p53, Hedgehog, Apelin, FoxO, and Hippo signaling pathways to orchestrate multilayered regulation of GC physiology, promoting proliferation, enhancing estrogen and progesterone synthesis and secretion, and inhibiting apoptosis. These findings provide mechanistic insights and suggest feasible strategies to improve fertility in female livestock. - Source: PubMed
Publication date: 2026/03/25
Yi LeiLiu JingwenChen WenwuXiao LanlinChen BoheLiu XiaolinLiu CaihongXu XinFu XianchuangLiufu SuiMa Haiming - Fat deposition plays a crucial role in regulating the production performance and meat quality of broilers. Although the heterogeneity of mammalian adipocytes has been extensively studied, research on the molecular mechanisms underlying differences in lipid droplet accumulation in avian adipocytes remains limited. This study confirmed a significant positive correlation (R > 0.81, < 0.001) between the SSC signal and lipid droplet content via fluorescence staining of lipid droplets, Oil Red O staining, and triglyceride (TG) quantification. Based on this, a label-free sorting strategy using SSC signals was established to sort differentiated chicken preadipocytes, obtaining high lipid droplet (H) and low lipid droplet (L) subpopulations, which were subsequently subjected to transcriptome sequencing and differential gene expression (DEG) analysis, followed by GO and KEGG enrichment analysis. The results indicated no significant differences in the expression of adipogenesis marker genes (, , , , ) between the high lipid droplet (H) and low lipid droplet (L) groups, suggesting that both groups are at similar stages of differentiation. KEGG analysis revealed that both the H vs. NC and L vs. NC comparisons were enriched in common pathways, including the PPAR signaling pathway, ECM-receptor interaction, focal adhesion, cytokine-receptor interaction, and calcium-Apelin signaling pathway, suggesting that both groups of cells had activated the adipogenesis program. GO analysis showed that, in both H vs. NC and L vs. NC comparisons, differentially expressed genes (DEGs) were enriched in biological processes (BPs) related to cell adhesion, nucleosome assembly, chromatin remodeling, and receptor activity, as well as cellular components (CCs) such as the extracellular matrix, cytoskeleton, and nucleosome organization, indicating extensive gene reprogramming and activation of signaling transduction during differentiation. In the H vs. L comparison, enriched pathways included ABC transporters, ECM-receptor interaction, focal adhesion, gap junctions, microtubule-related processes, and neuroactive ligand-receptor interactions, involving lipid transmembrane transport, cytoskeleton stabilization, and signal transduction regulation, suggesting that high lipid droplet cells are more mature in lipid droplet transport, storage, and homeostasis maintenance. GO enrichment results further supported this conclusion, as H vs. L specifically enriched processes related to microtubule-related processes, cell cycle, and redox reactions (BPs), as well as chromosome organization, cytoskeleton, and motor activity (CC/MF), indicating that high lipid droplet cells maintain lipid droplet fusion and metabolic homeostasis via enhanced microtubule transport and antioxidant regulation. Differential gene analysis revealed that the L group upregulated genes associated with fatty acid synthesis and elongation (, , , , ), cholesterol and isoprenoid biosynthesis (, , , , , , ), and fatty acid oxidation (, , , ), reflecting a metabolic characteristic of concurrent lipid synthesis and mobilization; the H group, conversely, upregulated genes associated with lipid droplet formation and storage (, , , , ), lipid transport (, , , , ), and antioxidant defense (, , ), exhibiting a storage and homeostasis-oriented metabolic state. In the NC, L, and H groups, the expression of five genes-, , , , and -showed a gradual increase, suggesting that these genes were associated with preadipocyte differentiation and lipid droplet deposition. In summary, although the high and low lipid droplet subpopulations of chicken preadipocytes exhibit similar differentiation states, they form distinct metabolic orientations. The L group is characterized by active lipid synthesis, fatty acid oxidation, and membrane lipid remodeling, while the H group predominantly features lipid droplet storage, lipid transport, and antioxidant homeostasis. This study highlights the molecular mechanisms underlying the metabolic heterogeneity of avian adipocytes and provides a theoretical basis for poultry fat deposition regulation and genetic improvement. - Source: PubMed
Publication date: 2026/03/12
Wang BoyuLi YantaoWang YakeChen JiayiWang JialiLi XiaopingLi Zhenhui - - Source: PubMed
Publication date: 2026/03/17
Zhao YonghengGong TingyueLi HaoLin HaipingYu MinhaoLuo YangZhong MingQin Jun - Tumor metabolism is characterized by dynamic plasticity, but there is a lack of appropriate tools to detect metabolic changes across different tumor stages, limiting the application of metabolism-targeted therapies. Our study introduces a noninvasive liquid biopsy approach, utilizing exosomes to reflect the metabolic profile of primary tumors at the transcriptome level. We observed a significant correlation between cholesterol synthesis and the response to neoadjuvant chemotherapy in breast cancer, particularly with non-pathologic complete response (non-pCR). Methylsterol monooxygenase 1 (MSMO1) was identified as a key factor influencing breast cancer chemosensitivity. MSMO1 regulates the metabolism of 14-demethyllanosterol (T-MAS), contributing to chemotherapy resistance via the PERK/eIF2α/ATF4/CHOP signaling pathway. Notably, plasma exosomal levels of MSMO1 may serve as a predictive biomarker for identifying patients who may benefit from T-MAS-mediated chemosensitization strategies, offering a promising approach for personalized breast cancer treatment. - Source: PubMed
Publication date: 2026/01/27
Ren HengyuWang XulirenShao ZhiboXiong MinChi WeiruSang YutingZhang QiWang ZehaoLiu DouwanerZhang LiyiChen MingZhu HanXue JingyanXiu BingqiuChi YayunWu Jiong