Ask about this productRelated genes to: SOD1 Blocking Peptide
- Gene:
- SOD1 NIH gene
- Name:
- superoxide dismutase 1
- Previous symbol:
- ALS, ALS1
- Synonyms:
- IPOA
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: SOD1 Blocking Peptide
Related articles to: SOD1 Blocking Peptide
- Mutations in superoxide dismutase 1 are the second most common genetic cause of ALS, usually associated with prevalent lower motor neuron phenotypes. We describe a 66-year-old woman with slowly progressive spastic paraparesis, initially diagnosed as primary lateral sclerosis, who carried a heterozygous p.D91A mutation. Clinical and neurophysiological findings indicated predominant upper motor neuron involvement, an unusual presentation for this mutation. This case broadens the phenotypic spectrum and highlights the importance of early genetic testing in atypical motor syndromes, given the availability of targeted therapies where diagnostic delay may limit benefit. - Source: PubMed
Publication date: 2026/05/25
Tavaglione LauraMadonia NiccolòCorrado LuciaComi CristoforoD'Alfonso SandraMazzini LetiziaDe Marchi Fabiola - Social status profoundly influences animal behavior through neural plasticity, yet the cellular mechanisms that mediate reconfiguration of neuromodulatory systems remain poorly understood. Here, we investigated status-dependent structural changes in the posterior tubercular nucleus (PTN) of adult zebrafish. Animals were assigned to four social conditions: communal, isolated, dominant, or subordinate. Using markers for cell proliferation (PCNA) and birth-dating (BrdU), we demonstrate that social dominance significantly enhances cell proliferation, leading to an increased population of PTN dopaminergic neurons. In contrast, subordinate and isolated fish exhibited suppressed proliferation and elevated expression of superoxide dismutase 1 (SOD1), suggesting that chronic social stress induces an oxidative burden that may lead to neuronal loss. Furthermore, we identified evidence of neurotransmitter phenotypic plasticity; subordinate fish displayed a significantly higher ratio of glutamatergic () to dopaminergic () expression in PTN neurons compared to dominants, suggesting a status-dependent shift in neuromodulatory identity. Multivariate principal component analysis showed distinct neurobiological profiles that separate social ranks, suggesting that status-dependent plasticity is a coordinated multi-modal response whereby increased BrdU and PCNA expression clustered with the dominant profile while increased expression of cellular stress and shift to glutamate cellular identity clustered with social subordinate and isolate profiles. Collectively, our results improve our understanding of how social experience reshapes the zebrafish brain through integrated changes in cell proliferation, cellular shift in neurotransmitter identity and regulation of cellular viability; thus, providing a potential mechanism for the maintenance of stable behavioral phenotypes in competitive social environments. - Source: PubMed
Publication date: 2026/05/08
Adams Carrie LScott Emily MIssa Fadi A - Red raspberry (Rubus idaeus L.) cultivation is often constrained by drought stress, which reduces fruit yield and quality. Melatonin (MT) plays an important role in plant stress tolerance. This study examined how exogenous MT improves drought tolerance in red raspberry at the squaring stage. It focused on changes in photosynthetic performance, antioxidant capacity, leaves anatomical structure, gene expression, and hormone homeostasis. - Source: PubMed
Publication date: 2026/05/23
Guo JuanjuanCheng SiqiFu ZiqianDong QinglongJia PengLuan HaoanZhang XuemeiQi Guohui - Astaxanthin (ATX), a natural antioxidant whose benefits in age-related liver and kidney damage remain unclear. We established a D-galactose-induced ageing model in rats and observed the daily behaviour of the rats. Using staining methods to detect ROS, apoptosis and histopathological changes in liver and brain tissue. Determination of antioxidant levels of IL-2, IL-6 and AGES in rats. Assessment of cognitive function using the Morris water maze and ChAT. The mRNA and protein expression levels of Nrf2, Bach1, SOD1, SOD2, HO-1 were determined by real-time PCR and Western blotting. To investigate the role of the Nrf2/Bach1-ARE pathway, we used ML385, a specific inhibitor of the Nrf2 pathway, to treat rats in the inhibitor group. Aging rats showed impaired learning and memory, along with decreased levels of neurotransmitters and antioxidant enzymes. ATX and vitamin E (VE) interventions significantly alleviated these symptoms and activated the Nrf2/Bach1-ARE pathway in liver and brain tissues of aged SD rats. Furthermore, the protective effects of ATX were attenuated by the addition of the Nrf2 inhibitor ML385. ATX reduces oxidative stress and ameliorates liver and brain damage in aged rats via activation of the Nrf2/Bach1-ARE pathway. - Source: PubMed
Publication date: 2026/05/23
Zhang PanpanZhang XunMa SiyuJiang MengqiangZhao Wenhong - Ruminants experience major metabolic stress during the periparturient period, leading to negative energy balance (NEB), oxidative stress, and inflammation. While NEB is well studied in dairy cows, molecular responses to feed restriction in locally adapted fat-tailed sheep breeds remain unclear. This study aimed to study the effect of phased feed restriction and parturition on hepatic genes related to antioxidant defense, NADPH regeneration, and inflammation in Lori Bakhtiari and Turki Qashqai ewes. Twenty ewes were used in this study. The control group (Ctrl; n=10) received pre- and postpartum diets to meet 100% of the energy requirements. The Feed Restricted group (FR; n=10) received a diet to simulate a sudden energy deficit prepartum and postpartum. Liver biopsies were collected on week -3 and 3 relative to parturition. Pro-inflammatory cytokines (IL-6, IL-8, TNFα) were unaffected by FR or parturition. The hepatic mRNA expression of GCLM remained constant in the FR group but decreased in the Ctrl group postpartum. In addition, GCLM mRNA abundance was lower in the FR group compared to the Ctrl group prepartum, but higher postpartum. The hepatic mRNA expression of SRXN1 increased postpartum in the FR group but remained constant in Ctrl. In addition, SRXN1 showed higher abundance in the FR group than in the Ctrl group both prepartum and postpartum. Both hepatic mRNA expression of GPX3 and GPX4 were constant in the FR group but increased in the Ctrl group postpartum. Thus, no differences in GPX3 and GPX4 were detected between groups prepartum but were lower in the FR group compared to the Ctrl group postpartum. In addition, FR downregulated the hepatic mRNA expression of GCLC, G6PD, 6PGD, CAT, SOD1, and SOD3, while increasing GR1. Parturition decreased the hepatic mRNA expression GCLC, G6PD, 6PGD, and TXNRD1, and increased Hb, SOD1, and SOD3 mRNA abundance. Feed restriction reduced key hepatic antioxidant and NADPH-regenerating genes, while parturition further intensified oxidative processes. Despite these sudden changes in dietary energy prepartum and postpartum, inflammatory cytokines remained constant, indicating that fat-tailed ewes prioritize redox adaptation over inflammation under nutritional stress and parturition-related metabolic demands. - Source: PubMed
Publication date: 2026/05/19
Pazir RahimZarrin MousaAhmadpour AmirHernández-Castellano Lorenzo E