Ask about this productRelated genes to: ZNF648 Blocking Peptide
- Gene:
- ZNF648 NIH gene
- Name:
- zinc finger protein 648
- Previous symbol:
- -
- Synonyms:
- FLJ46813
- Chromosome:
- 1q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-10-18
- Date modifiied:
- 2018-11-23
Related products to: ZNF648 Blocking Peptide
Related articles to: ZNF648 Blocking Peptide
- To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). - Source: PubMed
Kwak Soo HeonHernandez-Cancela Ryan BDiCorpo Daniel ACondon David EMerino JordiWu PeitaoBrody Jennifer AYao JieGuo XiuqingAhmadizar FaribaMeyer MariahSincan MuratMercader Josep MLee SujinHaessler JeffreyVy Ha My TLin ZhaotongArmstrong Nicole DGu ShaopengTsao Noah LLange Leslie AWang NingyuanWiggins Kerri LTrompet StellaLiu SiminLoos Ruth J FJudy RenaeSchroeder Philip HHasbani Natalie RBos Maxime MMorrison Alanna CJackson Rebecca DReiner Alexander PManson JoAnn EChaudhary Ninad SCarmichael Lynn KChen Yii-Der IdaTaylor Kent DGhanbari Mohsenvan Meurs JoycePitsillides Achilleas NPsaty Bruce MNoordam RaymondDo RonPark Kyong SooJukema J WouterKavousi MaryamCorrea AdolfoRich Stephen SDamrauer Scott MHajek CatherineCho Nam HIrvin Marguerite RPankow James SNadkarni Girish NSladek RobertGoodarzi Mark OFlorez Jose CChasman Daniel IHeckbert Susan RKooperberg CharlesDupuis JoséeMalhotra Rajeevde Vries Paul SLiu Ching-TiRotter Jerome IMeigs James B - Provision of feed is a major determinant of overall profitability in beef production systems, accounting for up to 75% of the variable costs. Thus, improving cattle feed efficiency, by way of determining the underlying genomic control and subsequently selecting for feed efficient cattle, provides a method through which feed input costs may be reduced. The objective of this study was to undertake gene co-expression network analysis using RNA-Sequence data generated from Longissimus dorsi and liver tissue samples collected from steers of two contrasting breeds (Charolais and Holstein-Friesian) divergent for residual feed intake (RFI), across two consecutive distinct dietary phases (zero-grazed grass and high-concentrate). Categories including differentially expressed genes (DEGs) based on the contrasts of RFI phenotype, breed and dietary source, as well as key transcription factors and proteins secreted in plasma were utilised as nodes of the gene co-expression network. - Source: PubMed
Publication date: 2024/03/04
Keogh KateKenny D AAlexandre P AMcGee MReverter A - Type 2 diabetes mellitus (T2D) confers a two- to three-fold increased risk of cardiovascular disease (CVD). However, the mechanisms underlying increased CVD risk among people with T2D are only partially understood. We hypothesized that a genetic association study among people with T2D at risk for developing incident cardiovascular complications could provide insights into molecular genetic aspects underlying CVD. - Source: PubMed
Publication date: 2023/07/28
Kwak Soo HeonHernandez-Cancela Ryan BDiCorpo Daniel ACondon David EMerino JordiWu PeitaoBrody Jennifer AYao JieGuo XiuqingAhmadizar FaribaMeyer MariahSincan MuratMercader Josep MLee SujinHaessler JeffreyVy Ha My TLin ZhaotongArmstrong Nicole DGu ShaopengTsao Noah LLange Leslie AWang NingyuanWiggins Kerri LTrompet StellaLiu SiminLoos Ruth J FJudy RenaeSchroeder Philip HHasbani Natalie RBos Maxime MMorrison Alanna CJackson Rebecca DReiner Alexander PManson JoAnn EChaudhary Ninad SCarmichael Lynn KChen Yii-Der IdaTaylor Kent DGhanbari Mohsenvan Meurs JoycePitsillides Achilleas NPsaty Bruce MNoordam RaymondDo RonPark Kyong SooJukema J WouterKavousi MaryamCorrea AdolfoRich Stephen SDamrauer Scott MHajek CatherineCho Nam HIrvin Marguerite RPankow James SNadkarni Girish NSladek RobertGoodarzi Mark OFlorez Jose CChasman Daniel IHeckbert Susan RKooperberg CharlesDupuis JoséeMalhotra Rajeevde Vries Paul SLiu Ching-TiRotter Jerome IMeigs James B - Maternal smoking during pregnancy (MSDP) is a significant risk factor for the development of foetal, neonatal, and childhood morbidities. We hypothesized that infants exposed to MSDP have a distinct proteomic expression in their term placentas compared to infants without such an exposure. A total of 39 infants exposed (cord blood cotinine levels of >1 ng/mL) and 44 infants not exposed to MSDP were included in the study. Women with chronic disease, body mass index of > 30, or a history of uterine surgery were excluded. Total proteome abundance was analysed with quantitative mass spectrometry. For univariate analysis of differences in placental protein levels between groups, ANOVA with multiple testing corrections by the Benjamini-Hochberg method was used. For multivariate analysis, we used principal component analysis, partial least squares, lasso, random forest, and neural networks. The univariate analyses showed four differentially abundant proteins (PXDN, CYP1A1, GPR183, and KRT81) when heavy and moderate smoking groups were compared to non-smokers. With the help of machine learning, we found that an additional six proteins (SEPTIN3, CRAT, NAAA, CD248, CADM3, and ZNF648) were discriminants of MSDP. The placental abundance of these ten proteins together explained 74.1% of the variation in cord blood cotinine levels (p = 0.002). Infants exposed to MSDP showed differential abundance of proteins in term placentas. We report differential placental abundance of several proteins for the first time in the setting of MSDP. We believe that these findings supplement the current understanding of how MSDP affects the placental proteome. - Source: PubMed
Publication date: 2023/05/18
Chelslín FelixLodefalk MariaKruse Robert - Human ZNF648 is a novel poly C-terminal C2H2 zinc finger protein identified amongst the most dysregulated proteins in erythroid cells differentiated from iPSC. Its nuclear localisation and structure indicate it is likely a DNA-binding protein. Using a combination of ZNF648 overexpression in an iPSC line and primary adult erythroid cells, ZNF648 knockdown in primary adult erythroid cells and megakaryocytes, comparative proteomics and transcriptomics we show that ZNF648 is required for both erythroid and megakaryocyte differentiation. Orthologues of ZNF648 were detected across Mammals, Reptilia, Actinopterygii, in some Aves, Amphibia and Coelacanthiformes suggesting the gene originated in the common ancestor of Osteichthyes (Euteleostomi or bony fish). Conservation of the C-terminal zinc finger domain is higher, with some variation in zinc finger number but a core of at least six zinc fingers conserved across all groups, with the N-terminus recognisably similar within but not between major lineages. This suggests the N-terminus of ZNF648 evolves faster than the C-terminus, however this is not due to exon-shuffling as the entire coding region of ZNF648 is within a single exon. As for other such transcription factors, the N-terminus likely carries out regulatory functions, but showed no sequence similarity to any known domains. The greater functional constraint on the zinc finger domain suggests ZNF648 binds at least some similar regions of DNA in the different organisms. However, divergence of the N-terminal region may enable differential expression, allowing adaptation of function in the different organisms. - Source: PubMed
Publication date: 2021/11/01
Ferguson Daniel C JMokim Juraidah HajiMeinders MarjoleinMoody Edmund R RWilliams Tom ACooke SarahTrakarnsanga KongtanaDaniels Deborah EFerrer-Vicens IvanShoemark DeborahTipgomut ChartsiamMacinnes Katherine AWilson Marieangela CSingleton Belinda KFrayne Jan