Ask about this productRelated genes to: TBC1D10C Blocking Peptide
- Gene:
- TBC1D10C NIH gene
- Name:
- TBC1 domain family member 10C
- Previous symbol:
- -
- Synonyms:
- FLJ00332, Carabin, EPI64C
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-10
- Date modifiied:
- 2016-10-05
Related products to: TBC1D10C Blocking Peptide
Related articles to: TBC1D10C Blocking Peptide
- Childhood obesity is a growing global health crisis associated with an increased risk of metabolic and cardiovascular diseases in adulthood. While accumulating evidence implicates immune dysregulation in obesity pathogenesis, the specific transcriptional alterations of immune cells, particularly NK cells and T cells in the context of childhood obesity, and their potential as non-invasive diagnostic biomarkers, remain largely unexplored. Here, we investigated the transcriptional alterations of NK cells and T cells in childhood obesity and evaluated their potential as non-invasive diagnostic biomarkers. To this end, we integrated bulk RNA-seq datasets (GSE205668 and GSE87493), adipose single-cell RNA-seq data (GSE159960), and blood qPCR validation to identify NK- and T-cell-related diagnostic biomarkers for childhood obesity. Differential expression analysis and WGCNA were applied to the bulk datasets to derive obesity-associated candidates, and single-cell RNA-seq was used to define immune-cell composition, infer NK-cell pseudotemporal dynamics, and quantify cell-cell communication. Genes shared between the bulk and single-cell analyses were prioritized using an ensemble machine-learning workflow comprising 110 model configurations and five feature-selection methods. TBC1D10C expression was validated by qPCR in an independent cohort of 29 children. Transcriptome-based analyses indicated reduced relative representation of NK cells and T cells in childhood obesity, with altered transcriptional programs and inferred impairment of NK-CD4 + T-cell communication. A 13-gene NK- and T-cell-based diagnostic signature was derived, and TBC1D10C was consistently prioritized by all feature-selection methods. The signature showed good discrimination between childhood obesity and controls across datasets (AUC 0.753-0.808), and comparable performance was observed for TBC1D10C alone. Enrichment analyses associated higher TBC1D10C expression with immune pathways, including Th1/Th2 differentiation, IL-17 signaling, and NK cell-mediated cytotoxicity. qPCR confirmed significant upregulation of TBC1D10C in peripheral blood from children with obesity. Across independent cohorts and platforms, TBC1D10C was identified as a reproducible NK- and T-cell-associated biomarker for childhood obesity, and immune dysregulation relevant to obesity pathophysiology may be reflected by its expression. Therefore, we propose TBC1D10C as a promising diagnostic biomarker and highlight its potential role in the immunopathology of childhood obesity. - Source: PubMed
Publication date: 2026/04/15
Huang HouyanHuang YangZhang YupingJiang YeShi PeiWang YingyingLiu SujuanXu PingWang JuanjuanZhou Taocheng - Abdominal aortic aneurysm (AAA) and major depressive disorder (MDD) are prevalent conditions with substantial global health burdens. Growing clinical evidence indicates a close relationship between them, implicating shared pathogenic mechanisms of immune dysregulation and inflammation. Deciphering this molecular interplay is critical, as it may reveal unified therapeutic strategies for these distinct disorders. This study aims to identify such shared molecular pathways, elucidate their co-pathogenesis, and discover novel therapeutic targets with dual relevance. - Source: PubMed
Publication date: 2026/02/13
Dong ChenXie JianhuaShen RuiPan ChengliangDong QingZhang JiangmeiYu KunwuZeng Qiutang - Recent clinical studies have reported that myo-inositol is consistently elevated in plasma of patients with heart failure (HF), yet its role in cardiac dysfunction remains poorly understood. Myo-inositol is specifically transported into cells by the sodium-myo-inositol co-transporter-1 (SMIT1), a member of the sodium-glucose co-transporter (SGLT) family expressed in the heart. While myo-inositol is essential for phosphoinositide signalling, osmoregulation, and metabolic homeostasis, dysregulation of SMIT1-mediated myo-inositol transport may contribute to key pathological mechanisms in HF. This study aims to elucidate the role of SMIT1 in the failing heart, especially during left ventricular remodelling that precedes it. - Source: PubMed
Marino AliceCumps JulienGuilbert LauraGeiser AngélineBaufays ClaireGinion AudreyFerté LauraBattault SylvainDe Matos FionaAmbroise JeromeZuurbier Coert JLezoualc'h FrankPestiaux CamillePyka GrzegorzKerckhofs GreetRoderick H LlewelynBertrand LucHorman SandrineBeauloye Christophe - Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, often diagnosed at advanced stages due to a lack of reliable early biomarkers. Recent studies suggest that the traditional Chinese medicine (TCM) body constitution, particularly the Yang-Deficiency Constitution (YDC), may influence tumour development by altering the immune microenvironment. However, the mechanistic connection between YDC and ccRCC prognosis remains largely unexplored. - Source: PubMed
Publication date: 2025/11/20
Kho Boon SengZhou ZongyuanLiu RuiSui YihangZhang YingnanYao JiaqiLu HuanhuanZhou GuoweiZhang BoWang Yinyin - Dapagliflozin (DAPA) are clinically effective in improving diabetic nephropathy (DN). However, whether and how chromatin accessibility changed by DN responds to DAPA treatment is unclear. Therefore, we performed ATAC-seq, RNA-seq, and weighted gene correlation network analysis to identify the chromatin accessibility, the messenger RNA (mRNA) expression, and the correlation between clinical phenotypes and mRNA expression using kidney from three mouse groups: db/m mice (Controls), db/db mice (case group), and those treated with DAPA (treatment group). RNA-Seq and ATAC-seq conjoint analysis revealed many overlapping pathways and networks suggesting that the transcriptional changes of DN and DAPA intervention largely occured dependently on chromatin remodeling. Specifically, the results showed that some key signal transduction pathways, such as immune dysfunction, glucolipid metabolism, oxidative stress and xenobiotic and endobiotic metabolism, were repeatedly enriched in the analysis of the RNA-seq data alone, as well as combined analysis with ATAC-seq data. Furthermore, we identified some candidate genes (UDP glucuronosyltransferase 1 family, Dock2, Tbc1d10c, etc.) and transcriptional regulators (KLF6 and GFI1) that might be associated with DN and DAPA restoration. These reversed genes and regulators confirmed that pathways related to immune response and metabolism pathways were critically involved in DN progression. - Source: PubMed
Shen JianxiaoYing LiangWu JiajiaFang YanZhou WenyanQi ChaojunGu LeyiMou ShanYan YuruTian MingNi ZhaohuiChe Xiajing