Ask about this productRelated genes to: ELOVL7 Blocking Peptide
- Gene:
- ELOVL7 NIH gene
- Name:
- ELOVL fatty acid elongase 7
- Previous symbol:
- -
- Synonyms:
- FLJ23563
- Chromosome:
- 5q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-17
- Date modifiied:
- 2015-09-11
Related products to: ELOVL7 Blocking Peptide
Related articles to: ELOVL7 Blocking Peptide
- The TMPIT/TMEM120/NET29 family of transmembrane proteins is conserved in eukaryotes, but its functions are controversial in mammals and have not been reported in plants. Structurally, these proteins were supposed to contain a coenzyme A (CoA)-binding motif and exhibit high similarity to that of ELOVL7, an enzyme involved in VLCFA (very long-chain fatty acid) elongation. Here, we report that due to functional redundancy of Arabidopsis TMPIT1 and TMPIT2, single null-type mutants grew normally. However, they constitute an essential gene pair for cell survival after the first meiotic division; thus, only double heterozygotes could be maintained in the laboratory. The leakage-type double mutants, where tmpit1 is leaky and tmpit2 is null, are viable with a visible defect of epicuticular waxes-derivatives of VLCFAs. Wild-type TMPIT1 and TMPIT2 were targeted to the cis-Golgi network, endoplasmic reticulum, and nuclear envelope. The leaky mutations, carrying short deletions in the N-terminus cytosolic region of TMPIT1, blocked the Golgi localization, leading to abnormal Golgi morphology. Free VLCFA levels in these mutants were increased, but C24/C26 sphingolipid levels-another group of VLCFA derivatives-were reduced. Detailed complementary tests revealed that TMPITs from barley, tomato, and rubber tree rescued the wax phenotypes of Arabidopsis mutants. ELOVL7, even after adding the N-terminus of Arabidopsis TMPIT1, could not rescue Arabidopsis mutants, indicating that the mechanism of TMPITs and ELOVL7 differ. A point mutation that destroys the CoA binding motif of Arabidopsis TMPIT1 simultaneously damages its functionality. Our work provides genetic evidence that plant TMPITs regulate the metabolic fluxes of VLCFAs to waxes and sphingolipids. - Source: PubMed
Publication date: 2026/04/24
Chen JieYang XinxingLou SiyingMa YuanHuang MinhuaMa LinxingHan NingBian HongwuTu MinQiu TingYang YanjunYang WanxiWang Junhui - One important element impacting meat quality is fat metabolism, which mainly affects meat features through intramuscular fat deposition. Chinese native yellow-feathered broilers and white-feathered broilers differ significantly in intramuscular fat concentration. This study used transcriptomic and metabolomic sequencing technologies to identify a total of 173 differentially expressed genes and 259 differential metabolites in the pectoral muscles of Chahua Chicken No. 2 and Cobb broiler in order to explore the genetic mechanisms by which lipid metabolism influences meat quality in Chinese indigenous yellow-feathered and white-feathered broilers. These included differentially expressed genes like FABP1, LPL, ELOVL7, SLC27A1, MOGAT1, and ULK2, which were enriched in pathways relevant to lipid metabolism and showed strong associations with γ-linolenic acid and palmitaldehyde, two distinct metabolites. In order to develop local chicken germplasm resources and breed superior indigenous chicken varieties, these candidate genes could serve as the genetic foundation for the variations in meat quality and lipid metabolism between Chinese native yellow-feathered and white-feathered broilers. - Source: PubMed
Publication date: 2025/12/25
Li MengyuanLiu MengqianYang YuRuan JinruiGu ZifuGe ChangrongCao Weina - Podocytopathy is an emerging global health concern characterized by the injury of podocytes through various direct or indirect mechanisms. Recent research has highlighted a potential link between podocyte loss and various programmed cell death pathways, while the precise mechanisms of podocyte injury remain ambiguous. We conducted single-nucleus RNA sequencing (snRNA-seq) on kidney tissues from adriamycin-induced nephropathy (AN) mice (BALB/c, male) and renal biopsy samples from patients with different types of podocytopathy, such as focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD) and obesity-related glomerulopathy (ORG). We found podocytes in diseased groups exhibited elevated ferroptosis scores based on the gene module score of programmed cell death pathways. Targeted lipidomics analysis revealed high phospholipids (PLs) levels containing long-chain polyunsaturated fatty acyl (LC-PUFA) tails. Metabolic pathway activity analysis indicated dysregulation of fatty acid elongation in podocytes of the AN group. We further reveal that the upregulation of Elovl7 in injured podocytes led to the accumulation of PLs with LC-PUFA tails, resulting in heightened sensitivity to ferroptosis. The results were confirmed by podocyte specific Elovl7 knockout mice and Elovl7 knockdown podocyte cell line. In conclusion, our study visualized injured podocytes and substantial podocyte loss from multiple podocytopathies. This phenomenon could potentially be attributed to the increased synthesis of LC-PUFAs facilitated by Elovl7, which leads to accumulation of intracellular lipid peroxidation and ultimately leading to ferroptosis. - Source: PubMed
Publication date: 2025/11/24
Kang MinchaoZhan XiaojiangHuang XinyuZhao YitingWang XiaoLi QiuyuZhu JinjunLiu FeiLi MeiheBai LinnanWen JiejunWang XinniZhou LeiWei RuipengQing JianboYan PingLu MingxiMao JianhuaWu Junnan - We investigated molecular characteristics and tissue distribution of elongation of very long chain fatty acids (ELOVL) genes in the chicken (Gallus gallus) genome. The research specifically examines the expression levels of these genes in chickens fed diets enriched with varying concentrations of curcumin. The aim is to uncover the potential roles and functions of ELOVL genes in the metabolism of fatty acids (FAs) in this species. In the experimental design, Hy-Line Brown commercial laying hens were selected for a feeding trial lasting 10 weeks. During this period, the hens were fed diets supplemented with curcumin at 100, 200, 300, and 400 mg/kg. The results revealed several critical insights: (1) It was confirmed that the ELOVL genes in Gallus gallus are orthologues of those found in vertebrates, indicating a shared evolutionary lineage; (2) There were noteworthy differences in how ELOVL genes, except ELOVL1 and ELOVL7, were distributed across various tissues and how they responded to dietary curcumin, prompting the need for comprehensive promoter analyses to better understand their functions in chickens; (3) The addition of curcumin to the diet did not increase omega-3 FAs in egg yolk; and (4) Dietary curcumin modulated ELOVL mRNA transcription in Gallus gallus. However, the intricate and multifaceted nature of FA metabolism presents challenges to fully grasping the implications of these results, highlighting the necessity for further in-depth investigations in this area. - Source: PubMed
Publication date: 2025/10/13
Dumlu BüşraBölükbaşi Şaziye CananBayir Abdulkadir - Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to have deleterious effects on child and adult development; however, less is known about the relationship between mother-newborn exposure levels. The objective of this study is to understand prenatal PCB exposure and its association with gene expression, using data from a cohort of exposed mothers and infants in eastern Slovakia. For 91 mothers and infants participating in this study, serum PCB concentrations were determined using gas chromatography and high-resolution mass spectrometry. Affymetrix microarray was performed utilizing Human Genome U133 Plus 2.0 gene chip. Statistical analysis compared the genetic expression levels of high versus low exposure mother-infant pairs (< 368.57 ng/g lipid vs. > 368.57 ng/g lipid). Statistical analysis results showed that mother's blood and cord blood PCB concentrations were highly correlated. Results showed that higher levels of PCB concentrations were associated with differential expressions of multiple genes. Global gene analysis identified significant dysregulation of genes XIST, EXOC6B, EIF1AY, and RPS4Y1. Gender-based gene analysis identified significant dysregulation of genes RUFY1, S100A8, ELOVL7, FXYD3, DEFB124, and DAB2. Further such investigations should be implemented to confirm these observations and more fully define the legacy of environmental PCB contamination. - Source: PubMed
Publication date: 2025/09/20
Saleem AmaraVolz AndrewMondal TanmoyLoffredo Christopher ATrnovec TomasMurinova Lubica PalkovicovaConka KamilDrobna BeataGhosh Somiranjan