Ask about this productRelated genes to: ALOX15B Blocking Peptide
- Gene:
- ALOX15B NIH gene
- Name:
- arachidonate 15-lipoxygenase type B
- Previous symbol:
- -
- Synonyms:
- 15-LOX-2
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-22
- Date modifiied:
- 2019-01-18
Related products to: ALOX15B Blocking Peptide
Related articles to: ALOX15B Blocking Peptide
- To integrate multiscale embedded gene co-expression network analysis (MEGENA) and Mendelian randomisation (MR) to identify new pathogenic factors associated with breast cancer (BC). - Source: PubMed
Wang YangXie RuiZhang HuimingGe Zhicheng - Primary acquired nasolacrimal duct obstruction (PANDO) is a common cause of epiphora in adults, yet the biochemical environment within the nasolacrimal duct (NLD) remains poorly understood. This study aimed to characterize the proteomic composition of NLD lavage fluid and identify subtype-specific molecular features distinguishing membranous and mucinous obstruction. Paired tear and NLD lavage fluid (NLD-LF) samples were collected from patients undergoing dacryoendoscopic recanalization, and proteomic profiling was performed using LC-MS/MS. A total of 1345 proteins were identified in NLD-LF and 767 in tear fluid, revealing a distinct NLD-specific proteome. Although the membranous and mucinous subtypes shared broadly similar protein compositions, differentially expressed proteins highlighted divergent biochemical pathways. The membranous subtype showed enrichment of keratinization-related processes involving , , and , suggesting epithelial remodeling and cornification. In contrast, the mucinous subtype exhibited upregulation of proteins involved in lipid metabolism, carboxylic acid biosynthesis, and sulfur compound metabolism, including , , and , indicating metabolic conditions that promote mucin-lipid interactions, glycan sulfation, and redox-dependent mucin cross-linking. These findings provide new insights into the protein composition of NLD lavage fluid and suggest molecular differences between the membranous and mucinous obstruction subtypes. - Source: PubMed
Publication date: 2026/03/12
You HeejeongBang WonseokKang ByeongsooBack SeunghoonPark JunyoungJu MinjungPark Jong-MoonLew Helen - Postmenopausal osteoporosis (PMOP) is characterized by bone loss attributed to estrogen deficiency; however, the involvement of ferroptosis in its pathogenesis has yet to be fully elucidated. The objective of this study was to explore the regulatory mechanism of the CEBPA/ALOX15B axis in PMOP, with a focus on modulating ferroptosis. - Source: PubMed
Publication date: 2026/03/17
Wang TingtingLi JingyiLi ChongWang ZhifangZhang LixiaHan ChaoQi GuangzhaoXu LijunZheng Lili - Low-grade gliomas(LGGs) show significant clinical and molecular heterogeneity, complicating progression prediction with conventional indicators. Metabolic reprogramming, a cancer hallmark, is linked to immune microenvironment remodeling, yet its role in LGG prognostic modeling remains underexplored. This study aims to develop a robust metabolism-related prognostic signature and elucidate its interaction with the immune microenvironment. - Source: PubMed
Publication date: 2026/02/10
Liu HaobinWu YuxiaoSun HaoyuHan XiaoLiu QianZhang YueningZhang Jinling - Bladder cancer (BC) is significantly more prevalent in men than in women, yet female patients often experience higher recurrence rates and poorer prognosis. - Source: PubMed
Publication date: 2026/02/09
Zeber-Lubecka NataliaBilski KonradDąbrowska MichalinaGoryca KrzysztofZiemska-Legięcka JoannaOstrowski JerzyDobruch JakubHennig Ewa E