Ask about this productRelated genes to: ACADL Blocking Peptide
- Gene:
- ACADL NIH gene
- Name:
- acyl-CoA dehydrogenase long chain
- Previous symbol:
- -
- Synonyms:
- LCAD, ACAD4
- Chromosome:
- 2q34
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-07
- Date modifiied:
- 2017-09-21
Related products to: ACADL Blocking Peptide
Related articles to: ACADL Blocking Peptide
- Oral squamous cell carcinoma (OSCC) is a biologically heterogeneous malignancy with poor clinical outcomes. Hypoxia and lipid metabolic reprogramming are important drivers of OSCC progression and treatment adaptation, and these processes are biologically interconnected. However, prognostic studies integrating hypoxia- and lipid metabolism-related features in OSCC remain limited. Here, transcriptomic data from TCGA-HNSC-OSCC were integrated with curated hypoxia- and lipid metabolism-related genes to identify candidate genes, construct a prognostic signature, and characterize its biological relevance through enrichment analysis, immune profiling, single-cell RNA-sequencing analysis, and RT-qPCR validation. A four-gene signature consisting of STC2, CAV1, ACADL, and PLA2G2D showed stable prognostic performance in the TCGA-HNSC-OSCC cohort and the external validation cohort GSE41613. The risk signature remained significantly associated with overall survival after adjustment for clinicopathological factors and retained prognostic discrimination across stage- and nodal status-defined subgroups. The high- and low-risk groups displayed distinct pathway, immune, mutational, and predicted drug sensitivity features. Notably, PLA2G2D showed the strongest association with differential immune infiltration, whereas single-cell analysis identified endothelial cells as a major CAV1-enriched population with active intercellular communication and dynamic state transitions. These findings define a hypoxia- and lipid metabolism-related prognostic signature and support its relevance to immune remodeling and endothelial cell context in OSCC. - Source: PubMed
Publication date: 2026/05/19
Zhao LiWang JialeJiang KaiyuanWang KunZhang Linglin - Aberrant epithelial remodeling, driven by a shift from ciliated to goblet cell ratio, is central to chronic nasal inflammation. Despite the known role of metabolism in normal epithelial differentiation, the specific metabolic reprogramming patterns underlying this pathological shift of nasal epithelium induced by type 2 inflammatory milieu is poorly understood. This study aimed to delineate the key metabolic pathways involved in aberrant nasal epithelial differentiation. - Source: PubMed
Publication date: 2026/04/27
Lin YutongYe XiaoyanZhong YingqianLi LiyueHuang XianxiongChen HexinMeng QingxiangGao YifangLi JianHuang JianfengLi Chunwei - Metabolic dysfunction-associated fatty liver disease (MAFLD) remains a global health burden with limited definitive therapies, highlighting the need for safe, food-derived interventions. Salvianolic acid B (SALB), a major water-soluble bioactive component of the traditional Asian health-promoting food , exhibits lipid-lowering, anti-inflammatory, and antioxidant properties, but its therapeutic potential and mechanisms in MAFLD remain unclear. Here, we employed an integrated approach combining network pharmacology, molecular docking, surface plasmon resonance affinity assays, lipidomics, and experiments in vitro and in vivo to address this gap. Network pharmacology combined with lipidomics identified PPAR-α as a key target of SALB. Molecular docking and SPR assays confirmed direct binding between SALB and PPAR-α. In vitro, SALB reduced triglyceride levels and lipid accumulation in HepG2 cells, enhanced fatty acid oxidation (FAO), and upregulated PPAR-α, PGC-1α, and FAO-related genes (CPT1, CPT2, ACADL, ACADVL). In HFD-fed mice, SALB decreased serum total cholesterol, triglycerides, LDL-C, ALT, AST, while increasing HDL-C. Additionally, SALB upregulated hepatic PPAR-α and FAO-related gene expression and suppressed hepatic reactive oxygen species production and inflammatory responses in both models. Collectively, our findings demonstrate that SALB, a natural food-derived bioactive compound, targets PPAR-α to ameliorate MAFLD by enhancing FAO, modulating lipid metabolism, and mitigating oxidative stress and inflammation. This work supports SALB's potential as a dietary supplement for MAFLD and metabolic disease management, reinforcing the value of exploring functional components from health-promoting food. - Source: PubMed
Publication date: 2026/03/19
Huang FengyanQiu ChenWang DannaNi YuanyingFu ZhuotaoFu LinchunLiang ChaoHuang ShangyiDeng Zhitong - Colon cancer (CC), a malignancy with high global incidence and mortality, remains a major public health burden. As a pivotal aspect of tumor metabolic reprogramming, fatty acid metabolism has drawn significant research interest. This study was designed to elucidate the relationship between fatty acid metabolism-related gene expression and prognosis in patients with CC. - Source: PubMed
Publication date: 2026/03/15
Zhou ShulingChen MinDong ZhikunYang YongShi XiaoruiKang HuanShi ChangbeiWang Xuan - Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid-laden macrophage foam cell formation and defective efferocytosis. This study aims to investigate the impact of GFPT2 on macrophage function in AS and its underlying mechanisms. - Source: PubMed
Publication date: 2026/04/14
Ke KunYan LeyeChen RongZhang ChuanrongYang WeizhuZhang ZefuLin Junqing