Ask about this productRelated genes to: ZNF256 Blocking Peptide
- Gene:
- ZNF256 NIH gene
- Name:
- zinc finger protein 256
- Previous symbol:
- -
- Synonyms:
- BMZF-3
- Chromosome:
- 19q13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2014-11-19
Related products to: ZNF256 Blocking Peptide
Related articles to: ZNF256 Blocking Peptide
- Opioid dependence is a complex disorder influenced by multiple factors, including aging and genetic factors. However, the underlying molecular mechanisms remain incompletely understood. This study integrated transcriptomic profiling, transcriptomic aging clock modeling, and GWAS analysis of brain samples to investigate molecular mechanisms associated with opioid dependence. One-hundred sixty-one DEGs were identified, including 147 upregulated and 14 downregulated genes in individuals with opioid dependence, which are involved in immune and inflammatory pathways (TNF signaling pathway). Network centrality analysis highlighted , , and as potential hub genes. was downregulated in older individuals with opioid dependence, whereas was upregulated in younger individuals. A transcriptomic aging clock showed moderate predictive performance (r=0.686, MAE=5.16) and revealed significant differences in age-prediction residuals between younger and older groups, suggesting altered age-related transcriptional states in opioid dependence. Two genes ( and ) were strongly associated with age-prediction residuals. An analysis of six GWAS studies identified 223 SNP associations, including genome-wide significant variants in and genes implicated in neuronal signaling and opioid pharmacology. Together, these findings highlight immune pathways, neuronal signaling, and aging-related molecular processes as key components of opioid dependence. - Source: PubMed
Publication date: 2026/07/27
Nguyen Hai DucMcRae Mary PeaceKim SangkyuKim Woong-Ki - Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive forms of liver cancer, with high morbidity and poor prognosis due to late diagnosis and limited treatment options. Despite advances in understanding its molecular mechanisms, effective biomarkers for early detection and targeted therapy remain scarce. Zinc finger protein 71 (ZNF71), a zinc-finger protein, has been implicated in various cancers, yet its role in HCC remains largely unexplored. This gap in knowledge underscores the need for further investigation into the ZNF71 of potential as a diagnostic or therapeutic target in HCC. - Source: PubMed
Qin KaiXiong Dan-DanQin ZhenLi Ming-JieLi QiHuang Zhi-GuangTang Yu-XingLi Jian-DiZhan Yan-TingHe Rong-QuanLuo JieWang Hai-QuanZhang Shu-QiChen GangWei Dan-MingDang Yi-Wu - Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation profiles in human DLBCL biopsy tissues with wildtype and mutated TET2. The microarray dataset GSE37365, containing two subseries: the genome‑wide gene expression dataset GSE37362 and the DNA methylation microarray dataset GSE37363, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using the limma package of R. Furthermore, differentially methylated sites and differentially methylated regions were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via GO stats and GSEABase packages respectively. Finally, the Pathview package was used to construct the network of enriched pathways. A total of 198 DEGs (106 up‑ and 92 downregulated) were obtained. A total of 602 shared differentially methylated genes (DMGs) were identified according to differentially methylated levels. A total of 12 overlapping genes were identified in DEGs and DMGs. It was observed that 9 of the 12 overlapped genes were downregulated and hypermethylated, with 24 GO terms and one KEGG pathway significantly enriched. The results of the present study demonstrated that the genes cryptochrome circadian clock 1, zinc finger protein (ZNF) interacting with K protein 1, ZNF134, ZNF256 and ZNF615, which were hypermethylated and downregulated in DLBCL patients with TET2 mutations, were the key genes in the association between DLBCL and TET mutations. These genes may act as potential biomarkers for the diagnosis of DLBCL in the future. - Source: PubMed
Publication date: 2017/07/21
Liu PengfeiJiang WenhuaZhao JinkunZhang Huilai - The Krüppel-associated box (KRAB)-containing zinc finger proteins (ZFPs) comprise the largest family of zinc finger transcription factors that function as transcriptional repressors. In the study of glial cell line-derived neurotrophic factor (GDNF)-RET signaling, we have identified bone marrow zinc finger 3 (BMZF3), encoding a KRAB-ZFP, as a GDNF-inducible gene by differential display analysis. The expression of BMZF3 transcripts in the human neuroblastoma cell line TGW increased 1h after GDNF stimulation, as determined by Northern blotting and quantitative reverse-transcriptase polymerase chain reaction. The BMZF3 possesses transcriptional repressor activity in the KRAB domain. BMZF3 interacts with a co-repressor protein, KRAB-associated protein 1 (KAP-1), through the KRAB domain and siRNA-mediated knockdown of KAP-1 abolished the transcriptional repressor activity of BMZF3, indicating that KAP-1 is necessary for BMZF3 function. Furthermore, siRNA-mediated silencing of BMZF3 inhibited cell proliferation. These findings suggest that BMZF3 is a transcriptional repressor induced by GDNF that plays a role in cell proliferation. - Source: PubMed
Publication date: 2007/12/03
Suzuki ChikageMurakumo YoshikiKawase YukariSato TomokoMorinaga TakatoshiFukuda NaoyukiEnomoto AtsushiIchihara MasatoshiTakahashi Masahide - To clone zinc finger genes expressed in hematopoietic system, we designed primers based on conserved Cys(2)/His(2) zinc finger sequences to amplify corresponding domains from mRNA of normal bone marrow and leukemia cell line NB4. DNA fragments of novel zinc finger genes were chosen and used as probe pool to screen cDNA libraries or subject to rapid amplification of cDNA ends in order to obtain full-length cDNA. Six cDNAs including whole open reading frame of zinc finger proteins, named as ZNF191, ZNF253 (BMZF-1), ZNF255 (BMZF-2), ZNF256 (BMZF-3), ZNF257 (BMZF-4), and ZNF254 (BMZF-5) were obtained. All six belong to the Krüppel-like zinc finger gene family, and typical transcriptional regulatory motifs exist in the N-terminal moiety, such as the SCAN box in ZNF191, and the KRAB domains in ZNF253, ZNF254, ZNF256, and ZNF257. A previously undefined sequence nominated as Krüppel-related novel box, which may represent a new transregulatory motif, was revealed at the N terminus of ZNF255. The transregulatory function of non-zinc finger regions of ZNF191, ZNF253, and ZNF255 were addressed in yeast and mammalian cells. The results indicated that ZNF255 might be a conditional transactivator, whereas ZNF253 and ZNF191 displayed a suppressive effect on the transcription in yeast and/or mammalian systems. - Source: PubMed
Han Z GZhang Q HYe MKan L XGu B WHe K LShi S LZhou JFu GMao MChen S JYu LChen Z