Ask about this productRelated genes to: LRRC4C Blocking Peptide
- Gene:
- LRRC4C NIH gene
- Name:
- leucine rich repeat containing 4C
- Previous symbol:
- -
- Synonyms:
- KIAA1580, NGL-1
- Chromosome:
- 11p12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-13
- Date modifiied:
- 2014-11-19
Related products to: LRRC4C Blocking Peptide
Related articles to: LRRC4C Blocking Peptide
- The past decade of multi-omics studies revealed perturbations in genetic, epigenetic, transcriptomic, proteomic, and metabolic networks in Alzheimer's disease (AD) detected in brain, cerebrospinal fluid (CSF), and blood biospecimens. Interactions among these networks and environmental factors are thought to contribute to risk and progression of this neurodegenerative dementia. Understanding the molecular and environmental risk in AD across all populations is essential in the development of cures and biomarkers for this complex disease. While most molecular studies to date have focused on populations of European ancestry, emerging multi-ancestry and multi-omics studies are revealing both shared and ancestry-specific biological signatures associated with disease susceptibility, biomarker profiles, and clinical presentation. Genomic studies show that established AD risk loci such as APOE, ABCA7, and TREM2 exhibit ancestry-dependent effects, while trans-ethnic genome-wide association studies identified novel disease risk loci (e.g., LRRC4C, LHX5-AS1) and protective haplotypes unique to African American (AA) and admixed populations. Epigenomic and transcriptomic studies reveal ancestry-linked variation in chromatin accessibility, DNA methylation, and gene expression, particularly in immune, lipid metabolism, and synaptic pathways. Proteomic analyses demonstrate differences in CSF and brain protein networks, including extracellular matrix and synaptic modules enriched or reduced in AA AD brains. Metabolomic and lipidomic data further highlight differential abundance in non-European cohorts. Integrating these multi-omics layers across ancestries provides a framework for understanding how genetic background and environmental context interact to drive AD heterogeneity. Such integrative, ancestry-aware approaches will refine biomarker interpretation, improve diagnostic accuracy, and guide development of therapeutics for AD. - Source: PubMed
Publication date: 2026/04/24
Shir DrorSeifar FatemehErtekin-Taner Nilüfer - To explore the novel mutations associated with asthma in core family lines of Han Chinese children by using GWAS and transmission disequilibrium test. - Source: PubMed
Publication date: 2026/03/17
Su XingyueWang BeileiWei XiaolingXue MinWang JingLiu GuohuaMa Xiang - Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer's Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer's disease (LOAD) susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6728 African American, 8899 Hispanic (HIS), and 3232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. - Source: PubMed
Publication date: 2025/07/17
Rajabli FaridBenchek PenelopeTosto GiuseppeKushch NicholasSha JinBazemore KatrinaZhu CongcongLee Wan-PingHaut JacobHamilton-Nelson Kara LWheeler Nicholas RZhao YiFarrell John JGrunin Michelle ALeung Yuk YeeKuksa Pavel PLi Dongheda Fonseca Eder LucioMez Jesse BPalmer Ellen LPillai JaganSherva Richard MSong Yeunjoo EZhang XiaolingIkeuchi TakeshiIqbal TahaPathak OmkarValladares OttoReyes-Dumeyer DollyKuzma Amanda BAbner ErinAdams Larry DAdams Perrie MAguirre AlyssaAlbert Marilyn SAlbin Roger LAllen MarietAlvarez LisaApostolova Liana GArnold Steven EAsthana SanjayAtwood Craig SAuerbach SanfordAyres GayleBaldwin Clinton TBarber Robert CBarnes Lisa LBarral SandraBeach Thomas GBecker James TBeecham Gary WBeekly DuaneBenitez Bruno ABennett DavidBertelson JohnBird Thomas DBlacker DeborahBoeve Bradley FBowen James DBoxer AdamBrewer JamesBurke James RBurns Jeffrey MBuxbaum Joseph DCairns Nigel JCantwell Laura BCao ChuanhaiCarlson Christopher SCarlsson Cynthia MCarney Regina MCarrasquillo Minerva MChasse ScottChesselet Marie-FrancoiseChin Nathaniel AChui Helena CChung JaeyoonCraft SuzanneCrane Paul KCribbs David HCrocco Elizabeth ACruchaga CarlosCuccaro Michael LCullum MunroDarby EveleenDavis BarbaraDe Jager Philip LDeCarli CharlesDeToledo JohnDick MalcolmDickson Dennis WDombroski Beth ADoody Rachelle SDuara RanjanErtekin-Taner NIlüferEvans Denis AFaber Kelley MFairchild Thomas JFallon Kenneth BFardo David WFarlow Martin RFernandez-Hernandez VictoriaFerris StevenFriedland Robert PForoud Tatiana MFrosch Matthew PFulton-Howard BrianGalasko Douglas RGamboa AdrianaGearing MarlaGeschwind Daniel HGhetti BernardinoGilbert John RGo Rodney C PGoate Alison MGrabowski Thomas JGraff-Radford Neill RGreen Robert CGrowdon John HHakonarson HakonHall JamesHamilton Ronald LHarari OscarHardy JohnHarrell Lindy EHead ElizabethHenderson Victor WHernandez MichelleHohman TimothyHonig Lawrence SHuebinger Ryan MHuentelman Matthew JHulette Christine MHyman Bradley THynan Linda SIbanez LauraJarvik Gail PJayadev SumanJin Lee-WayJohnson KimJohnson LeighKamboh M IlyasKarydas Anna MKatz Mindy JKauwe John SKaye Jeffrey AKeene C DirkKhaleeq AishaKikuchi MasatakaKim RonaldKnebl JaniceKowall Neil WKramer Joel HKukull Walter ALaFerla Frank MLah James JLarson Eric BLerner AlanLeverenz James BLevey Allan ILieberman Andrew PLipton Richard BLogue MarkLopez Oscar LLunetta Kathryn LLyketsos Constantine GMains DouglasMargaret Flanagan EMarson Daniel CMartin Eden RrMartiniuk FrankMash Deborah CMasliah EliezerMassman PaulMasurkar ArjunMcCormick Wayne CMcCurry Susan MMcDavid Andrew NMcDonough StefanMcKee Ann CMesulam MarselMiller Bruce LMiller Carol AMiller Joshua WMontine Thomas JMonuki Edwin SMorris John CMukherjee ShubhabrataMyers Amanda JNguyen TrungObisesan ThomasO'Bryant SidOlichney John MOry MarciaPalmer RaymondParisi Joseph EPaulson Henry LPavlik ValoryPaydarfar DavidPerez VictoriaPeskind ElainePetersen Ronald CPetrovitch HelenPierce AimeePolk MarshaPoon Wayne WPotter HuntingtonQu LimingQuiceno MaryQuinn Joseph FRaj AshokRaskind MurrayReiman Eric MReisberg BarryReisch Joan SRingman John MRoberson Erik DRodriguear MonicaRogaeva EkaterinaRosen Howard JRosenberg Roger NRoyall Donald RSabbagh MarwanSadovnick A DessaSager Mark ASano MarySaykin Andrew JSchneider Julie ASchneider Lon SSeeley William WSlifer Susan HSmall ScottSmith Amanda GSmith Janet PSonnen Joshua ASpina SalvatoreGeorge-Hyslop Peter StStarks Takiyah DStern Robert AStevens Alan BStrittmatter Stephen MSultzer DavidSwerdlow Russell HTanzi Rudolph ETilson Jeffrey LTrojanowski John QTroncoso Juan CTsolaki MagdaTsuang Debby WVan Deerlin Vivianna Mvan Eldik Linda JVance Jeffery MVardarajan Badri NVassar RobertVinters Harry VVonsattel Jean-PaulWeintraub SandraWelsh-Bohmer Kathleen AWhitehead Patrice LWijsman Ellen MWilhelmsen Kirk CWilliams BenjaminWilliamson JenniferWilms HenrikWingo Thomas SWisniewski ThomasWoltjer Randall LWoon MartinWright Clinton BWu Chuang-KuoYounkin Steven GYu Chang-EnYu LeiZhu XiongweiKunkle Brian WBush William SMiyashita AkinoriByrd Goldie SWang Li-SanFarrer Lindsay AHaines Jonathan LMayeux RichardPericak-Vance Margaret ASchellenberg Gerard DJun Gyungah RReitz ChristianeNaj Adam C - Previous studies have suggested a potential link between the gut microbiota and diverticulitis. However, the causal relationships as well as underlying mechanisms remain unclear. - Source: PubMed
Publication date: 2025/06/13
Hao WendeWang ZhenjunMa Huachong - Colon cancer (CRC) demonstrates significant heterogeneity, and identifying effective biomarkers can advance the development of precision therapies. Emerging evidence implicates SUMOylation-regulated genes as pivotal regulators of cancer-associated pathways, yet their prognostic potential and therapeutic implications in CRC remain unexplored. A comprehensive analysis of SUMOylation-regulated gene expression, clinical and prognostic value in CRC was performed using transcriptomic data from TCGA-COAD and GEO datasets. We identified 46 differentially expressed SUMOylation-regulated genes (33 upregulated, 13 downregulated) in CRC tumors versus normal tissues. Unsupervised clustering based on 216 SUMOylation-related genes stratified CRC patients into two distinct subtypes: SUMO Cluster 1 (aggressive phenotype, poor prognosis) and SUMO Cluster 2 (favorable prognosis). Cluster 1 exhibited advanced tumor stages (N-stage, p < 0.05) and may present an immunosuppressive microenvironment marked by reduced HLA/immune checkpoint gene expression, while Cluster 2 showed enhanced anti-tumor immunity (activated dendritic cells, γδ T cells). A five-gene SUMOylation-based prognostic signature (MC1R, LRRC4C, SAGE1, GJB6, HOXC5) was developed, and patients were divided into high Riskscore and low Riskscore groups with significant survival differences (log-rank p < 0.05). The nomogram integrating risk score, age, and stage demonstrated robust predictive accuracy (C-index = 0.763, AUC = 0.728-0.785). Nomoscore-high patients exhibited resistance to AMG.706 and ABT.888, suggesting therapeutic vulnerabilities. These findings highlight SUMOylation plays a critical role in CRC heterogeneity, immune modulation, and prognosis, offering a novel biomarker system for risk stratification and personalized therapy. - Source: PubMed
Publication date: 2025/05/20
Peng WenYang ZirongYan RuMu LanLi LanJin ShanTan Shisheng