Ask about this productRelated genes to: RNF44 Blocking Peptide
- Gene:
- RNF44 NIH gene
- Name:
- ring finger protein 44
- Previous symbol:
- -
- Synonyms:
- KIAA1100
- Chromosome:
- 5q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-02
- Date modifiied:
- 2016-10-05
Related products to: RNF44 Blocking Peptide
Related articles to: RNF44 Blocking Peptide
- To investigate the mechanism by which the effective-component combination of Bufei Yishen formula III (ECC-BYF III) ameliorates airway epithelial barrier injury in chronic obstructive pulmonary disease (COPD) through miRNA-mRNA regulatory networks. - Source: PubMed
Publication date: 2025/09/04
Liu ChunleiYue ChangyuanXing XiaoxiangHuang LidongWei YanxinZhao PengLi JianshengGuan Qingzhou - Circular RNAs (circRNAs) are RNA molecules frequently involved in tumorigenesis. This research study focuses on the relevance of hsa_circ_515 (circ_515) to non-small cell lung cancer (NSCLC) progression and the downstream targets involved. Differentially expressed circRNAs in NSCLC were screened using a GSE158695 dataset. Circ_515 was overexpressed and indicated poor outcomes in patients with NSCLC. Knockdown of circ_515 repressed proliferation and invasiveness, while potentiated cell cycle arrest and apoptosis of NSCLC cells, and upregulation of circ_515 led to converse trends. The candidate downstream transcripts of circ_515 were explored using integrated bioinformatic analyses. Ectopic expression of miR-296-5p reduced the malignance of NSCLC cells. Circ_515 sequestered miR-296-5p and blocked its suppressive role in RING finger protein 44 (RNF44) expression. Downregulation of RNF44 counteracted the oncogenic effects of circ_515. In vivo, the anti-tumor effects of circ_515 knockdown were reversed by miR-296-5p, while the tumor-promoting effects of circ_515 upregulation were abolished by RNF44 knockdown. All in all, our findings demonstrate that circ_515 sequesters miR-296-5p and elevates RNF44 expression to encourage the NSCLC progression. This study might provide new thoughts on NSCLC management. - Source: PubMed
Publication date: 2025/02/24
Sun LixinLu BeiLi ChongyuanXu Guangquan - Cuproptosis induces proteotoxic stress and eventually leads to cell death. However, the relationship between cuproptosis and lncRNAs in cervical cancer has not been fully elucidated. Therefore, we aim to explore the association among lncRNAs, cuproptosis and clinical features in cervical cancer. - Source: PubMed
Publication date: 2024/04/12
Huang YitongPan ChenxiangWu SuniYe FengYang Lihua - - Source: PubMed
Publication date: 2023/11/22
Liu XingguangZhao TengdaYuan ZheGe Shaohua - Glioma is the most common primary tumor in the central nervous system, and prognostic biomarkers are still lacking. HIC ZBTB transcriptional repressor 2 (HIC2) is a hypermethylated gene that plays an important functional role in cardiac development. However, the actual role of HIC2 in glioma progression remains unclear. This study aimed to investigate the function of HIC2 and whether it could be a prognostic biomarker in glioma. - Source: PubMed
Publication date: 2023/01/17
Luo FeifeiLiao YifuCao EndongYang YongTang KaiZhou DexiangZhou DongCai Haiping