Ask about this productRelated genes to: STAU1 Blocking Peptide
- Gene:
- STAU1 NIH gene
- Name:
- staufen double-stranded RNA binding protein 1
- Previous symbol:
- STAU
- Synonyms:
- PPP1R150
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-22
- Date modifiied:
- 2016-10-05
Related products to: STAU1 Blocking Peptide
Related articles to: STAU1 Blocking Peptide
- The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying mechanisms remain elusive. Here we identify non-specific cytotoxic cell receptor protein 1 (NCCRP1) as a critical and previously uncharacterized regulator of this process. - Source: PubMed
Publication date: 2026/08/05
Liu LuQi ShihaoShao LiyeCai JunyangZeng QingqingJiang XuMa FangLin Weiwei - - Source: PubMed
Publication date: 2026/08/01
Giordano AntonioNisoli EnzoCinti Saverio - Parkinson's disease (PD) is a complex neurodegenerative disorder with diverse molecular signatures that extend beyond the central nervous system. Peripheral blood serves as a minimally invasive source of transcriptomic biomarkers reflecting systemic inflammation, mitochondrial dysfunction, lysosomal impairment, and disrupted RNA processing-key pathways involved in PD. Long-read RNA sequencing with Oxford Nanopore Technologies (ONT) offers unprecedented detail of full-length transcripts, alternative isoforms, and RNA modifications, enabling more accurate detection of disease-related transcriptional changes. We conducted high-throughput ONT long-read RNA sequencing on blood samples from 145 individuals, including PD patients and age-matched healthy controls. RNA libraries were prepared using a cDNA-based protocol optimised for high-accuracy PromethION sequencing. Transcriptomes were quantified with ONT-specific pipelines, and analyses of differential gene expression (DGE), differential transcript expression (DEX), differential transcript usage (DTU), and alternative splicing were performed using ONT-aware tools such as DRIMSeq, DEXSeq, and stageR. Pathway enrichment linked disease-related changes to mitochondrial, lysosomal, and vesicle-trafficking pathways. Our analysis identified highly significant PD-associated transcriptional signatures in peripheral blood (SNCA, VPS13C, LRRK2, GRN, STAU1, NPTN, PARK7). Long-read sequencing uncovered extensive isoform-level dysregulation, including novel transcript variants (e.g., BCL2L2-PABPN1, SQSTM1) in pathways relevant to PD, such as autophagy and endolysosomal trafficking. DTU analyses revealed shifts in isoforms of LRRK2 and GBA1, indicating widespread disturbances in RNA processing. Enrichment analysis showed activation of molecular pathways linked to neurodegeneration. This study provides the largest long-read blood transcriptomic dataset in PD to date, demonstrating that ONT sequencing can resolve isoform-level changes and reveal systemic molecular signatures of PD. Our findings support the development of blood-based RNA biomarkers and the establishment of long-read transcriptomics as a transformative approach for genomic pathology in PD. - Source: PubMed
Publication date: 2026/07/08
Koks SulevMuldmaa MariPrice JackWhiley LukeJakobson MailiSingleton LewisHowting DenisePfaff Abigail LChopra AbhaWatson MarkSikk KatrinTaba Pille - Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies, largely due to its poorly understood pathogenesis, which limits the development of effective early detection and targeted therapy. This study was designed to explore the potential role of the long non-coding RNA CDIPTOSP in OC progression. We observed high expression of CDIPTOSP in OC tissues and cell lines. Knockdown of CDIPTOSP impeded the proliferation and migration of OC cells. Using the RNA pull-down-Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) approach, we found that CDIPTOSP bound staufen double-stranded RNA binding protein 1 (STAU1). In turn, CDIPTOSP-STAU1 interactions were essential for KLF transcription factor 17 (KLF17) mRNA destabilization. Notably, depletion of KLF17 could rescue the tumor-suppressive effects caused by CDIPTOSP knockdown, whereas overexpression of KLF17 abolished the tumor-promoting effects induced by overexpressing CDIPTOSP. In conclusion, our study provided the first evidence of the CDIPTOSP/STAU1/KLF17 axis in the regulation of OC progression. - Source: PubMed
Publication date: 2026/05/15
Tong RuiqingYu XianglingXu BingyaWu TiantianLiu MengShen CongXu XiangxiangXia Fei - Human Staufen1 (hStau1, UniProt O95793.2) is a double-strand RNA (dsRNA) binding protein that modulates gene expression via mRNA-dependent mechanisms such as Staufen-mediated mRNA decay (SMD). This modular protein is dynamic and binds to both messanger RNA (mRNA) targets and proteins. The Staufen-swapping motif (SSM) domain is reported to play a key role in hStau1 dimerization. Our data confirm that SSM deletion decreases hStau1 dimerization. This protein shows higher protein disorder in the absence of SSM. Thus, SSM plays not only a key role in hStau1 dimerization but also modulates its tertiary structure. Surprisingly, increased disorder upon SSM deletion does not affect affinity for mRNA targets or protein/RNA stoichiometry but SMD efficiency since SMD targets are upregulated upon SSM deletion. In conclusion, hStau1 dimerization via SSM affects the overall structure and dynamics of the protein required for efficient regulation of gene expression via SMD. - Source: PubMed
Tripepi AndreaShakoor HumaZlobina MariaKlumpler TomášKubíčková MonikaHouser JosefKlapetek PetrLukavsky Peter Josef