Ask about this productRelated genes to: PPP1R3B Blocking Peptide
- Gene:
- PPP1R3B NIH gene
- Name:
- protein phosphatase 1 regulatory subunit 3B
- Previous symbol:
- -
- Synonyms:
- GL, FLJ14005, PPP1R4
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-29
- Date modifiied:
- 2015-11-18
Related products to: PPP1R3B Blocking Peptide
Related articles to: PPP1R3B Blocking Peptide
- Identifying targets that promote M2 macrophage polarization in the hypoxic plaque microenvironment is crucial for modulating immune metabolism and optimizing energy dynamics in atherosclerotic cardiovascular disease (ASCVD) treatment. The high phagocytic activity of M2 macrophages reduces foam cell formation. Their secretion of anti-inflammatory cytokines enhances plaque stability, mitigating atherosclerosis progression. Through high-throughput sequencing and multi-omics bioinformatics analysis, protein phosphatase 1 regulatory subunit 3B (PPP1R3B) is identified as a key regulator linking glycogen metabolism to macrophage polarization. The integrated approach combined transcriptomic analysis of human atherosclerotic plaques (GSE57614) with RNA-seq of PPP1R3B-modulated macrophages, revealing its dual role. PPP1R3B induces anti-inflammatory M2 macrophage polarization and maintains energy supply in plaques. Its absence accelerates plaque progression. PPP1R3B regulates M2 macrophage polarization and energy metabolism via phosphorylated STAT3 (p-STAT3), which plays a dual role by activating anti-inflammatory transcriptional programs through the PPAR-γ/PGC-1α/CD206 axis in the nucleus and enhancing glycogenolysis-mediated metabolic activity via the p-GSK-3β/p-PYGL/p-GYS2 axis in mitochondria. STAT3 plays a dual role in metabolic regulation and macrophage phenotype modulation. By orchestrating glycogen metabolic reprogramming, PPP1R3B-induced M2 polarization presents a novel strategy for anti-ASCVD drug development, with significant potential for clinical translation. - Source: PubMed
Publication date: 2025/09/23
Shen LinYu JunchaoChen WeiqianBi YanranYang ZhangyuLu ChenyingJiang ChengliYang YangChen MinjiangZou JianhuaLv LingchunChen XiaoyuanJi Jiansong - Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with a poor prognosis despite multiple available treatments. Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, has recently emerged as a promising strategy for cancer therapy, particularly in head and neck malignancies. However, its regulatory mechanisms remain largely unclear. In this study, we demonstrate that TP53 transcriptionally activates PHKG2, which promotes ferroptosis. PHKG2 enhances the activity of protein phosphatase 1 (PP1) by phosphorylating PPP1R3B, disrupting its interaction with PP1C. Activated PP1 dephosphorylates NRF2, promoting its nuclear export and suppressing GPX4 transcription, thereby enhancing ferroptosis sensitivity. Both in vitro and in vivo, PHKG2 overexpression significantly suppressed tumor growth and increased lipid peroxidation levels. These findings define a previously unrecognized TP53/PHKG2-PP1-NRF2 signaling axis in the regulation of ferroptosis in HNSCC and suggest a novel therapeutic target. - Source: PubMed
Publication date: 2025/08/30
Yu YalianLuan MengZang JianLuo LeWang TianyiWang TianciWang YanWang Hongbo - A quarter of the world population is estimated to have metabolic dysfunction-associated steatotic liver disease. Here, we aim to understand the impact of liver trait-associated genetic variants on fat content and tissue volume across organs and body compartments and on a large set of biomarkers. - Source: PubMed
Publication date: 2025/06/02
Ahmad ShafqatCarrasquilla Germán DLangner TaroMenzel UweAhmad NoumanSayols-Baixeras SergiDekkers Koen FKennedy BeatriceMalmberg FilipHammar UlfRomero-Lado María JCensin Jenny CNguyen DiemMartínez Mora AndrésKilpeläinen Tuomas OLind LarsEriksson Jan WStrand RobinKullberg JoelAhlström HåkanFall Tove - Megalobrama amblycephala, a herbivorous freshwater fish species native to China, has become an important aquaculture species in Chinese freshwater polyculture systems due to its high economic value. How morphological traits and gene expression of cultured populations are influenced by different artificial selection pressures compared to wild populations is still poorly understood. In the current study, a combination of morphological analysis, cytochrome b sequence characterization, and whole genome re-sequencing methods was employed to investigate the genetic differences caused by artificial selection, including the genetic diversity and differentiation of wild and cultured populations. The genetic diversity of the population was classified based on the cytochrome b gene as follows: wild population (WP) > common breeding population (CP) > artificially created strain (AS). Morphological traits showed that the values of head length, body depth, dorsal fin length and pelvic fin length were the largest in the WP, smaller in the CP and the smallest in the AS. But the largest body width was in the AS, smaller in the CP, and the smallest in the WP. A significant finding was the identification of several candidate genes involved in carbohydrate metabolism, including Adcy9, Eif4ebp1, Gnai2b, Ppp1r3b, Ptprfa, Ptprfb and Slc8a2b. The data generated by this research not only contribute to a deeper understanding of the molecular-level characteristics but also provide crucial scientific foundations for the conservation and genetic improvement of this species. - Source: PubMed
Publication date: 2025/08/05
Cui YunwenHu XigengWang HuanshanWang ChunlingCao WenxuanZhang Futie - Maternal undernutrition (MUN) causes severe metabolic disruption in the offspring of mammals. Here we determined the role of histone modification in hepatic gene expression in late-gestation fetuses of nutritionally restricted cows, an established model using low-nutrition (LN) and high-nutrition (HN) conditions. The chromatin immunoprecipitation sequencing results show that genes with an altered trimethylation of histone 3 lysine 4 (H3K4me3) are associated with cortisol synthesis and secretion, the PPAR signaling pathway, and aldosterone synthesis and secretion. Genes with the H3K27me3 alteration were associated with glutamatergic synapse and gastric acid secretion. Compared to HN fetuses, promoter H3K4me3 levels in LN fetuses were higher in , , , and but lower in and . Intriguingly, genes with the greatest expression changes (>1.5-fold) exhibited the anticipated up-/downregulation from elevated or reduced H3K4me3 levels; however, a significant relationship was not observed between promoter CpG methylation or H3K27me3 and the gene set with the greatest expression changes. Furthermore, the stress response genes , , , and were upregulated in the MUN fetal liver, suggesting involvement of the response in activation. Thus, H3K4me3 likely plays a crucial role in MUN-induced physiological adaptation, altering the hepatic gene expression responsible for the integrated stress response and systemic energy metabolism, especially circulating lipoprotein lipase regulation. - Source: PubMed
Publication date: 2025/08/04
Muroya SusumuOjima KoichiShimamoto SakiSugasawa TakehitoGotoh Takafumi