Ask about this productRelated genes to: HOMEZ Blocking Peptide
- Gene:
- HOMEZ NIH gene
- Name:
- homeobox and leucine zipper encoding
- Previous symbol:
- KIAA1443
- Synonyms:
- -
- Chromosome:
- 14q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-21
- Date modifiied:
- 2015-08-25
Related products to: HOMEZ Blocking Peptide
Related articles to: HOMEZ Blocking Peptide
- Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal expansion within the bone marrow (BM) and remains largely incurable despite recent therapeutic advances. While prognostic indicators have predominantly focused on tumor-intrinsic features, the BM tumor microenvironment (TME) plays a critical role in disease progression and therapeutic resistance. Here, we present a robust prognostic model derived from transcriptomic profiling of the CD138-negative BM fraction, enabling precise risk stratification of patients undergoing bortezomib-based induction therapy. Using bioinformatic deconvolution and a custom immune-stromal signature matrix, we identified gene expression patterns representative of the MM TME. Through rigorous feature selection and elastic-net penalized Cox regression, we developed the MM-5C model, consisting of five genes (SOX11, METTL11B, C3, RBM10, and HOMEZ), which stratifies patients into biologically distinct risk groups and demonstrates prognostic independence from established cytogenetic and clinical staging systems. This model underscores the pivotal role of TME components in shaping therapeutic outcomes and offers a scalable, clinically translatable tool for personalized risk stratification. Our findings highlight the necessity of integrating microenvironmental insights into MM prognostication and pave the way for microenvironment-informed therapeutic decision-making. - Source: PubMed
Publication date: 2025/12/03
Gargano GraziaPappagallo Susanna AnitaQuinto Angela MariaRossini BernardoGramegna DorianaMondelli PaoloVegliante Maria CarmelaOpinto GiuseppinaEsposito FlaviaZaccaria Gian MariaSolli VincenzaPalumbo OrazioTerragna CarolinaCavo MicheleDel Buono NicolettaGuarini AttilioCiavarella Sabino - Tight junction complexes are crucial features of brain endothelial cells, as they restrict the paracellular route across the blood-brain barrier. Tight junction disruption has been observed in conjunction with numerous diseases of the CNS. In such cases, the organization or integrity of cell-cell junctions may be analyzed with a variety of automated computer programs that quantitatively assess junction images. Here, we directly compare two previously developed python-based programs-JAnaP and IJOQ- for the semi- or fully automated analysis of tight junctions in human stem cell-derived brain-like endothelial cells. Cells were infected with S. pneumoniae and S. agalactiae to initiate junction disruption, and occludin and ZO-1 were analyzed in mock and infected groups via JAnaP and IJOQ. JAnaP and IJOQ both yielded comparable results for the quantification of tight junction disruption in brain endothelial cells. While JAnaP rendered data at the cellular level and gave more information regarding junction phenotype, IJOQ significantly reduced user time and eliminated potential user bias. Our results suggest that JAnaP and IJOQ are both appropriate for quantifying tight junction integrity in brain endothelial cells, and both may offer distinct advantages depending on their context of use. - Source: PubMed
Mauser Henry DCaroza JanessaHomez Shane NicoleArnett Alyssa SCutts William DLam Daryl WThornton JustinAdams WalterKim Brandon J - In critically ill patients receiving invasive mechanical ventilation, switching from controlled to assisted ventilation is a crucial milestone toward ventilator liberation. The optimal timing for switching to assisted ventilation has not been studied. Our objective was to determine whether a strategy of early compared with delayed switching affects the duration of invasive mechanical ventilation, ICU length of stay, and mortality. We conducted a target trial emulation using the prospective, global WEAN SAFE (the WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) dataset. Patients were eligible for switching if they were still on controlled mechanical ventilation, were not receiving neuromuscular blockers, and had Pa:Fi ratios >150 mm Hg. We compared an "early switching" strategy (switch within 1 day after reaching switching eligibility criteria) with a "delayed switching" strategy (switch 1 or more days after reaching the switching eligibility criteria). The primary outcome was the 28-day cumulative incidence of successful extubation. Secondary outcomes included 28-day and 90-day ICU discharge and ICU mortality. A total of 1,489 patients met the switching eligibility criteria. The early-switch group had, on average, 4 additional days of being successfully extubated over the 28-day period (95% confidence interval [CI], 3-6 days; < 0.001) compared with the delayed group, with a higher difference in cumulative incidence of successful extubation at Day 28 (7% [95% CI, 0-13%]; = 0.04). Early switching was associated with an 11% higher cumulative incidence of ICU discharge at Day 28 (95% CI, 7-18%; < 0.001) and an average of 7 additional days discharged from the ICU over the 90-day period (95% CI, 4-12 days; < 0.001) compared with delayed switching. ICU mortality rates did not differ between the strategies. Early switching from controlled to assisted ventilation is associated with shorter duration of invasive mechanical ventilation and ICU stay compared with delayed switching. - Source: PubMed
Reep Carmen A TWils Evert-JanFleuren Lucas MBreskin AlexanderBellani GiacomoLaffey John GBrochard Laurent JPham TàiHeunks Leo - Expression of microRNAs, such as miR-365, is known to be dysregulated in many tumors, including oral cancers, although little is known about their role or functions. The objective of this project is to evaluate the downstream targets of miR-365 to determine any potential pathways or effects. Downstream targets for miR-365 (miRdatabase target scores > 90) were used for qPCR screening of oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27). Each oral cancer cell line expressed miR-365 downstream targets molybdenum cofactor synthesis-2 (MOCS2), erythropoietin receptor (EPOR), IQ motif containing-K (IQCK), carboxypeptidase A3 (CPA3), solute carrier family 24 member-3 (SLC24A3), and coiled-coil domain containing 47 (CCDC47)-although the expression levels varied somewhat. However, differential results were observed with ubiquitin protein ligase E3 component n-recognin-3 (UBR3), nudix hydrolase-12 (NUDT12), zinc finger CCHC-type containing-14 (ZCCHC14), and homeobox and leucine zipper encoding (HOMEZ). These data suggest that many of the miR-365 targets are expressed in the oral cancers screened, with the differential expression of UBR3, ZCCHC14, HOMEZ, and NUDT12, which may be correlated with chemoresistance among two specific oral cancer cell lines (SCC25, SCC9). These results suggest this differential expression may signal potential targets for patient treatment with tumors exhibiting miR-365 and chemotherapeutic resistance. - Source: PubMed
Publication date: 2024/06/10
Yu BrendonKruse NathanielHoward Katherine MKingsley Karl - Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. - Source: PubMed
Publication date: 2023/01/21
Pham TàiHeunks LeoBellani GiacomoMadotto FabianaAragao IreneBeduneau GaëtanGoligher Ewan CGrasselli GiacomoLaake Jon HenrikMancebo JordiPeñuelas OscarPiquilloud LisePesenti AntonioWunsch Hannahvan Haren FrankBrochard LaurentLaffey John G