Ask about this productRelated genes to: Tigd4 Blocking Peptide
- Gene:
- TIGD4 NIH gene
- Name:
- tigger transposable element derived 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-22
- Date modifiied:
- 2016-10-25
Related products to: Tigd4 Blocking Peptide
Related articles to: Tigd4 Blocking Peptide
- Common forms of migraine are complex disorders characterized by significant clinical diversity. Their genetic basis has been extensively studied but remains unclear. This study represents the first pilot genome-wide association study (GWAS) integrating a polygenic risk score (PRS) in the Portuguese population, designed to identify migraine susceptibility loci through a case-control study and unravel population-specific variants. Genotyping data was acquired with Applied Biosystems Axiom™ PMDA array, producing 12,035,248 single-nucleotide polymorphisms (SNPs) post-imputation, providing a comprehensive scope for GWAS analysis. PRS models were created and tested using a k-folds cross-validation framework and the optimal significance threshold was assessed. We detected 12 potential risk loci corresponding to 12 lead SNPs (, /, , , , , , , , , and ). The top three variants (, / and ) were also supported by the PRS model. We highlight that several variants present putative biological relevance to migraine pathophysiology, reinforcing the importance of neurotransmitter release, synaptic transmission and the involvement of vascular components in migraine pathophysiology. - Source: PubMed
Publication date: 2026/06/06
De Marco RodrigoPucci KevinSantos MarianaGil-Gouveia RaquelCavadas BrunoSousa AldaAlves-Ferreira MiguelAzevedo LuísaLemos CarolinaDias Andreia - Hepatocellular carcinoma (HCC) is an aggressive cancer with limited therapies. Although transposable element-derived genes are increasingly linked to tumorigenesis, the role of the TIGD family in HCC remains unclear. This study examined the expression, clinical significance, and stemness-related features of TIGDs in HCC, emphasizing their prognostic and therapeutic potential. - Source: PubMed
Publication date: 2026/03/02
Liu JingChen XiaopengLiu ChengYang ChengweiLi Baoding - and , as two superfamilies of - () group, have been well-defined. However, the molecular evolution and domestication of transposons, once designated as an important family of the superfamily, are still poorly understood. - Source: PubMed
Publication date: 2020/07/22
Gao BoWang YaliDiaby MohamedZong WenchengShen DanWang SaisaiChen CaiWang XiaoyanSong Chengyi - Although they are unable to utilize muscle glycogen, McArdle mice adapt favourably to an individualized moderate-intensity endurance exercise training regime. Yet, they fail to reach the performance capacity of healthy mice with normal glycogen availability. There is a remarkable difference in the protein networks involved in muscle tissue adaptations to endurance exercise training in mice with and without glycogen availability. Indeed, endurance exercise training promoted the expression of only three proteins common to both McArdle and wild-type mice: LIMCH1, PARP1 and TIGD4. In turn, trained McArdle mice presented strong expression of mitogen-activated protein kinase 12 (MAPK12). - Source: PubMed
Publication date: 2018/02/14
Fiuza-Luces CarmenSantos-Lozano AlejandroLlavero FranciscoCampo RocíoNogales-Gadea GiselaDíez-Bermejo JorgeBaladrón CarlosGonzález-Murillo ÁfricaArenas JoaquínMartín Miguel AAndreu Antoni LPinós TomàsGálvez Beatriz GLópez Juan AVázquez JesúsZugaza José LLucia Alejandro